grant
BKV and JCV vaccine development
Organization DIVISION OF BASIC SCIENCES - NCILocation UNITED STATES
NIHUS FederalResearch GrantFY202521+ years oldAIDSAcquired Immune DeficiencyAcquired Immune Deficiency SyndromeAcquired Immunodeficiency SyndromeAcuteAdultAdult HumanAnimal ModelAnimal Models and Related StudiesAntibodiesAntibody ResponseBK PolyomavirusBK VirusBKV virusBaker's YeastBladderBladder CancerBladder Urinary SystemBrain DiseasesBrain DisordersBrewer's YeastCancersCapsid ProteinsChronicClinical TrialsCoat ProteinsDevelopmentDiseaseDisorderEncephalon DiseasesGeneral PopulationGeneral PublicGoalsHPVHumanHuman Papilloma VirusHuman PapillomavirusImmunocompromisedImmunocompromised HostImmunocompromised PatientImmunosuppressantsImmunosuppressed HostImmunosuppressive AgentsImmunosuppressive drugImmunosuppressive treatmentIndividualInfectious Human Wart VirusIntracranial CNS DisordersIntracranial Central Nervous System DisordersIntramuscularJC PolyomavirusJC Polyomavirus EncephalitisJC Polyomavirus EncephalopathyJC VirusKidney DiseasesKidney GraftingKidney TransplantationKidney TransplantsLegal patentLicensingMalignant Bladder NeoplasmMalignant NeoplasmsMalignant TumorMalignant Tumor of the BladderMalignant neoplasm of urinary bladderManuscriptsMediatingMiceMice MammalsModern ManMurineMusNephropathyPatentsPathologyPatientsPlayPolyomaPolyoma VirusesPolyomavirusPolyomavirus InfectionsPolyomavirus JCVPreventative vaccinePreventive vaccineProgressive Multifocal LeukoencephalopathyProphylactic vaccineRenal DiseaseRenal GraftingRenal TransplantationRenal TransplantsRiskRoleS cerevisiaeS. cerevisiaeSaccharomyces cerevisiaeSymptomsSystemTransplant RecipientsUrinary Bladder CancerUrinary Bladder Malignant TumorUrinary tractUrineVIVIPAROUS1 proteinVaccinesViralViral Coat ProteinsViral Outer Coat ProteinVirionVirusVirus ParticleVirus-like particleViviparous-1 proteinVp1 proteinWorkYeastsadulthooddamage to kidneydevelop a vaccinedevelop vaccinesdevelopment of a vaccinedevelopmentalfeedinghuman subjectimmune suppressive agentimmune suppressorimmunosuppressed patientimmunosuppressive substanceimmunosuppressorindustrial partnershipindustry partnerindustry partnershipinventionkidney damagekidney disorderkidney txmalignancymodel of animalneoplasm/cancerneutralizing antibodynovelpreventpreventingrecombinant virusrenal damagerenal disordersocial roletooltransplant patienturinary bladdervaccine developmentvirus-like nanoparticlesviruslike particlewart virus
Description preview
Two distinct polyomaviruses, called BKV and JCV, chronically infect the human urinary tract. Most healthy adults are stably infected with both viruses and occasionally shed infectious virions in the urine. Although BKV and JCV aren't known to cause overt symptoms in healthy individuals, each of the two viruses can cause severe pathology in…
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