grant
Bitter taste receptors in oral cancer tumor-associated macrophages
Organization UNIVERSITY OF PENNSYLVANIALocation PHILADELPHIA, UNITED STATESPosted 21 Aug 2025Deadline 31 May 2030
NIHUS FederalResearch GrantFY202520S Catalytic Proteasome20S Core Proteasome20S Proteasome20S ProteosomeAKTAcuteAdaptive Immune SystemAffectAgonistAkt proteinAnti-InflammatoriesAnti-Inflammatory AgentsAnti-inflammatoryAntigen PresentationApoptosisApoptosis PathwayApoptoticAssayAttentionB cell growth factorB-Cell Differentiation Factor-1B-Cell Growth Factor-1B-Cell Growth Factor-IB-Cell Proliferating FactorB-Cell Stimulating FactorB-Cell Stimulating Factor-1B-Cell Stimulation Factor-1B-Cell Stimulatory Factor-1BCDF-1BCGFBCGF-1BCSF 1BSF-1BSF1BinetrakinBioassayBiochemicalBiochemistryBiological AssayBiological ChemistryBlood monocyteBody TissuesC57BL/6 MouseCalcium oxideCancer cell lineCancerousCancersCarcinoma CellCaspaseCaspase GeneCategoriesCell BodyCell CommunicationCell Communication and SignalingCell InteractionCell SignalingCell-Death ProteaseCell-to-Cell InteractionCellsClassificationClinicalCyclic GMPCysteine EndopeptidasesCysteine ProteaseCysteine ProteinasesDataDeath RateDrugsELISAEndogenous Nitrate VasodilatorEndothelium-Derived Nitric OxideEnzyme-Linked Immunosorbent AssayExhibitsFamilyFlow CytofluorometriesFlow CytofluorometryFlow CytometryFlow MicrofluorimetryFlow MicrofluorometryG Protein-Complex ReceptorG Protein-Coupled Receptor GenesG-Protein-Coupled ReceptorsGPCRGenesGoalsGuanosine Cyclic MonophosphateGustationHumanICE-like proteaseIL-4IL4 ProteinImmuneImmune TargetingImmune infiltratesImmune mediated therapyImmune responseImmune systemImmunesImmunityImmunocompetentImmunohistochemistryImmunohistochemistry Cell/TissueImmunohistochemistry Staining MethodImmunologically Directed TherapyImmunotherapyImplantInfectionInfiltrationInflammatoryInhibition of ApoptosisInnate Immune SystemInterleukin-4Interleukin-4 PrecursorIntracellular Communication and SignalingInvestigationLeadLocationLymphocyte Stimulatory Factor 1MCGF-2MacropainMacrophageMacroxyproteinaseMalignant CellMalignant Epithelial CellMalignant NeoplasmsMalignant Oral Cavity NeoplasmMalignant Oral Cavity TumorMalignant Oral NeoplasmMalignant TumorMarrow monocyteMast Cell Growth Factor-2MeasurementMeasuresMediatingMedicationMetastasisMetastasizeMetastatic LesionMetastatic MassMetastatic NeoplasmMetastatic TumorMiceMice MammalsMitochondriaModern ManMononitrogen MonoxideMouth CancerMulticatalytic ProteinaseMurineMusMφNeoplasm MetastasisNitric OxideNitrogen MonoxideNitrogen ProtoxideOral CancerOral Cavity Squamous Cell CarcinomaOral squamous cell carcinomaOutcomeP aeruginosaP. aeruginosaPathologicPathway interactionsPatient outcomePatient-Centered OutcomesPatient-Focused OutcomesPatientsPatternPb elementPhagocytosisPharmaceutical AgentPharmaceutical PreparationsPharmaceuticalsPharmacologic SubstancePharmacological SubstancePhenotypePlayPopulationProcessProductionPrognosisProgrammed Cell DeathProsomeProteasomeProteasome Endopeptidase ComplexProtein Kinase BProteinsProteosomeProto-Oncogene Proteins c-aktPseudomonas aeruginosaPseudomonas pyocyaneaPublishingRAC-PK proteinRNA SeqRNA sequencingRNAseqReceptor ProteinRecurrenceRecurrentRoleSamplingSecondary NeoplasmSecondary TumorSentinelShapesSignal PathwaySignal TransductionSignal Transduction SystemsSignalingSignaling Factor Proto-OncogeneSignaling Pathway GeneSignaling ProteinSliceSolid NeoplasmSolid TumorStromal CellsSurgical OncologySurvival RateSystematicsT-Cell Growth Factor 2TCGATasteTaste BudsTaste PerceptionTestingThe Cancer Genome AtlasTherapeuticTissuesTongueTrainingTumor AntigensTumor CellTumor Cell MigrationTumor ImmunityTumor PromotionTumor TissueTumor-Associated AntigenTumor-associated macrophagesacquired immune systemanti-canceranti-tumor immunityantitumor immunitybiological signal transductionc-akt proteincGMPcalciacancer antigenscancer cellcancer immunitycancer metastasiscancer microenvironmentcancer progressioncombatcystein proteasecystein proteinasecysteine endopeptidasecytokinedesigndesigningdrug/agentendothelial cell derived relaxing factorenzyme linked immunoassayfightingflow cytophotometrygustatory perceptiongustatory processinggustatory responseheavy calcium oxideheavy metal Pbheavy metal leadhost responseimmune cell infiltrateimmune competentimmune system responseimmune therapeutic approachimmune therapeutic interventionsimmune therapeutic regimensimmune therapeutic strategyimmune therapyimmune-based therapiesimmune-based treatmentsimmuno therapyimmunoresponseimprovedimproved outcomeinsightkeratinocytelive cell imagelive cell imaginglive cellular imagelive cellular imagingmalignancymalignant mouth neoplasmmalignant mouth tumormigrationmitochondrialmonocytemortality ratemortality ratiomouth SCCmouth squamous cell carcinomamulticatalytic endopeptidase complexneoplasm progressionneoplasm/cancerneoplastic cellneoplastic progressionnew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic targetnew therapy targetnovelnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel therapeutic targetnovel therapy targetoncologic surgeryoral cavity SCCoral cavity canceroral squamous canceroral squamous carcinomapathogenpathwaypatient oriented outcomespharmaceuticalprotein expressionproto-oncogene protein RACproto-oncogene protein aktrac protein kinasereceptorrelated to A and C-proteinresponsesocial roletaste processingtaste receptortaste responsetherapeutic targettranscriptome sequencingtranscriptomic sequencingtumortumor behaviortumor cell metastasistumor growthtumor microenvironmenttumor progressiontumor-specific antigen
Description preview
PROJECT SUMMARY
Oral squamous cell carcinomas (OSCCs) are associated with poor prognosis and a 5-year mortality
rate of approximately 50%. These tumors are influenced by the cancer cells, tumor microenvironment, and
host immune system, with tumor-associated macrophages (TAMs) playing a pivotal role in shaping the immune
response and clinical…
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