Bisbiguanide analogues as probes for assessing membrane barrier function in multidrug resistant Gram-negative bacteria.
Description preview
Aim:
The key aim of this project is to develop a number of bisbiguanide-based membrane active probes to investigate the barrier properties of the Gram-negative membrane. The overarching aim is to identify chemical features of small molecules that enable them to penetrate and accumulate inside Gram-negative bacteria.
Remit:
This project aligns with…
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