grant
Biophysics of Large Membrane Channels
Organization EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENTLocation UNITED STATES
NIHUS FederalResearch GrantFY2025AffectAnesthestic DrugsAnesthetic AgentsAnesthetic DrugsAnestheticsAnionsAppearanceAreaAssayB anthracisB. anthracisBacillus anthracisBehaviorBenchmarkingBest Practice AnalysisBindingBinding ProteinsBinding SitesBioassayBiologicalBiological AssayBiophysicsCalcium Ion SignalingCalcium SignalingCancersCardiac DiseasesCardiac DisordersCell BodyCell DeathCell Membrane LipidsCellsCellular Metabolic ProcessCellular biologyChemicalsChloroplastsCombining SiteComplementComplement ProteinsComplexConeCysteineCytosolDataDegenerative Neurologic DisordersDependenceDevelopmentDiabetes MellitusDiffusionDiseaseDisorderDoseDrugsElectrophysiologyElectrophysiology (science)ElementsEmbryoEmbryonicEntropyEquilibriumExhibitsExposure toFillerFlow CytofluorometriesFlow CytofluorometryFlow CytometryFlow MicrofluorimetryFlow MicrofluorometryFluorescenceGenus HippocampusGeometryGram-Negative BacteriaGram-Positive BacteriaHalf-CystineHallucinogenic AgentsHallucinogenic DrugsHallucinogenic SubstancesHallucinogensHeart DiseasesHeightHemalysinsHemolysinHydrogen OxideIndividualIntegral Membrane ProteinIntrinsic Membrane ProteinIon ChannelIon TransportIonic ChannelsIonsIsoformsKineticsKnock-outKnockoutL-CysteineLigand Binding ProteinLigand Binding Protein GeneLipidsLocationMalignant NeoplasmsMalignant TumorMammaliaMammalsMediatingMedicationMembraneMembrane ChannelsMembrane LipidsMembrane Protein GeneMembrane ProteinsMembrane-Associated ProteinsMetabolicMethodsMicroscopyMitochondriaMitochondrial PorinMitochondrial ProteinsModelingMolecularMolecular ConfigurationMolecular ConformationMolecular InteractionMolecular StereochemistryMonitorMotionNAC precursorNervous System Degenerative DiseasesNeural Degenerative DiseasesNeural degenerative DisordersNeurodegenerative DiseasesNeurodegenerative DisordersNeurologic Degenerative ConditionsNeurophysiology / ElectrophysiologyOrganellesOrthologOrthologous GeneOuter Mitochondrial MembranePARK1 proteinPARK4 proteinPathologicPathologyPathway interactionsPatient Self-ReportPeripheralPharmaceutical PreparationsPhysicsPhysiologicPhysiologicalPropertyProtein BindingProtein ConformationProtein IsoformsProteinsProteomePsychedelic AgentsPsychedelicsPsychotomimetic AgentsQuartzRadialRadiusReactionReactive SiteRegulationReportingResolutionRoleS aureusS. aureusSNCASNCA proteinSeahorseSelf-ReportSpectroscopySpectrum AnalysesSpectrum AnalysisStaph aureusStaphylococcus aureusStructureSubgroupSurface ProteinsSystemTechniquesTechnologyTemperatureTimeToxinTransmembrane ProteinTransmembrane Protein GeneTricyclic Antidepressant DrugsTricyclic AntidepressantsTricyclic Antidepressive AgentsTubeTubulinVDAC mitochondrial porinVDAC proteinsVDAC1VDAC1 geneVDAC2VDAC2 geneVDAC3VDAC3 geneVoltage-Dependent Anion ChannelWatera-syna-synucleinalpha synucleinalpha synuclein genealphaSP22anion-selective channels voltage-dependentanthracisanthrax toxinasynbalancebalance functionbenchmarkbeta barrelbiologicbiological systemsbiophysical approachesbiophysical characteristicsbiophysical characterizationbiophysical foundationbiophysical measurementbiophysical methodologybiophysical methodsbiophysical parametersbiophysical principlesbiophysical propertiesbiophysical sciencesbiophysical techniquesbound proteincell biologycell metabolismcellular metabaolismcomplementationconformationconformationalconformational conversionconformational stateconformational transitionconformationallyconformationsdegenerative diseases of motor and sensory neuronsdegenerative neurological diseasesdevelopmentaldeviancydeviantdiabetesdiffuseddiffusesdiffusingdiffusionsdimerdrug/agentelectrophysiologicalexperimentexperimental researchexperimental studyexperimentsflexibilityflexibleflow cytophotometrygramicidin Aheart disordermalignancymembrane structuremitochondria porinsmitochondrialmitochondrial pore proteinnano meter scalenano meter sizednanometer scalenanometer sizednanoscalenecrocytosisneoplasm/cancerneurodegenerative illnessnon A-beta component of AD amyloidnon A4 component of amyloid precursorparticlepathwaypharmacologicpore forming proteinpore forming protein VDACporinprotein protein interactionpsychedelic drugpsychotomimetic drugrate of changereconstitutereconstitutionresolutionsresponsesingle moleculesmall moleculesocial rolestructural mutationstructural variantstructural variationsynucleinvoltagevoltage-dependent, anion-selective, channel forming protein, mitochondrialα synuclein geneα-synα-synuclein
Description preview
I. Global and local effects in lipid-mediated interactions between peripheral and integral membrane proteins.
Amphitropic proteins (APs) are a subfamily of water-soluble peripherally membrane-bound proteins that interact directly with the lipid membrane rather than with intrinsic membrane proteins. They are therefore strongly influenced by…
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