grant
Biophysical parameters of self-reactive TCR engagement in T1D
Organization UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAHLocation SALT LAKE CITY, UNITED STATESPosted 1 Mar 2023Deadline 29 Feb 2028
NIHUS FederalResearch GrantFY2026AffinityAllelesAllelomorphsAntigen PresentationAntigensAutoantigensAutoimmuneAutoimmune DiabetesAutoimmune DiseasesAutoimmune StatusAutoimmunityAutologous AntigensBeta CellBindingBrittle Diabetes MellitusCD4 CellsCD4 Positive T LymphocytesCD4 T cellsCD4 helper T cellCD4 lymphocyteCD4+ T-LymphocyteCD4-Positive LymphocytesCDR GeneCDR1CDR1 geneCDR34Cell BodyCell FunctionCell PhysiologyCell ProcessCellsCellular FunctionCellular PhysiologyCellular ProcessCerebellar Degeneration Related Autoantigen 1Cerebellar Degeneration Related Autoantigen, 34-KDComplementarity Determining RegionsComplexComplimentarity Determining RegionDataDiseaseDisease ProgressionDisorderDysfunctionEragrostisExhibitsExperimental Animal ModelFOXP3FOXP3 geneFailureFamilyForkhead Box P3Functional disorderGeneticGerm LinesGoalsHLA-DR4HLA-DR4 AntigenHistocompatibilityHumanHypervariable LoopHypervariable RegionsIDDMImmunoglobulin Hypervariable RegionInsulin CellInsulin Secreting CellInsulin-Dependent Diabetes MellitusJM2Juvenile-Onset Diabetes MellitusKetosis-Prone Diabetes MellitusKnowledgeMHC ReceptorMajor Histocompatibility Complex ReceptorMeasurementMeasuresMediatingMiceMice MammalsModelingModern ManMolecular InteractionMurineMusOutcomePeptide ReceptorPeptidesPhysiopathologyPredispositionPrevalenceProcessProteinsPublic HealthPublishingReceptor ActivationRegulatory T-LymphocyteRisk FactorsSCURFINSelf-AntigensSpecificityStructureSubcellular ProcessSudden-Onset Diabetes MellitusSurvey InstrumentSurveysSusceptibilitySystemT cell based immune therapyT cell based therapeuticsT cell based therapyT cell directed therapiesT cell immune therapyT cell immunotherapyT cell responseT cell targeted therapeuticsT cell therapyT cell treatmentT cell-based immunotherapyT cell-based treatmentT cellular immunotherapyT cellular therapyT lymphocyte based immunotherapyT lymphocyte based therapyT lymphocyte therapeuticT lymphocyte treatmentT-Cell ActivationT-Cell Antigen Receptor SpecificityT-Cell Antigen ReceptorsT-Cell DevelopmentT-Cell OntogenyT-Cell ReceptorT-Cell Receptor BetaT-Cell Receptor InteractionT-Cell Receptor SpecificityT-Cell Receptors beta-ChainT-CellsT-LymphocyteT-Lymphocyte DevelopmentT-cell therapeuticsT-cell transfer therapyT1 DMT1 diabetesT1DT1DMT4 CellsT4 LymphocytesTCR ActivationTCR InteractionTechnologyTeffTeff cellTestingTherapeuticTissue CompatibilityTregTreg adoptive therapyTreg therapyType 1 Diabetes MellitusType 1 diabetesType I Diabetes MellitusWorkactivate T cellsadoptive T cell transferadoptive T lymphocyte transferadoptive T-cell therapyadoptive therapy of regulatory T cellsantigen-specific T cellsautoimmune conditionautoimmune disorderautoimmunity diseaseautoreactive T cellbeta Chain Antigen T Cell Receptorbiophysical characteristicsbiophysical characterizationbiophysical measurementbiophysical parametersbiophysical propertiesdesigndesigningdiabetogeniceffector T cellhumanized micehumanized mouseimmunogenimprovedinsightinsulin dependent diabetesinsulin dependent type 1juvenile diabetesjuvenile diabetes mellitusketosis prone diabetesmechanical forcenew technologynovelnovel technologiespathophysiologyregulatory T-cellsresponseself-reactive T celltherapeutic T-cell platformthymus derived lymphocytetype I diabetestype one diabetesβ-cellβ-cellsβCell
Description preview
ABSTRACT
Major histocompatibility loci (MHC) are the largest genetic contributors to autoimmune susceptibility, including
type 1 diabetes. Our novel observations show that biophysical parameters of T cell receptor interactions with
peptide-MHC are altered in the context of susceptible MHC alleles. Dissecting the interaction between T cell
receptor…
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