grant
Biophysical mechanisms of gating and modulation in voltage-gated ion channel superfamily
Organization WASHINGTON UNIVERSITYLocation SAINT LOUIS, UNITED STATESPosted 3 May 2020Deadline 30 Apr 2028
NIHUS FederalResearch GrantFY2026AddressAlgorithmic AnalysesAlgorithmic AnalysisAnalyses of AlgorithmsAnalysis of AlgorithmsArchitectureArrhythmiaBindingBiologic ModelsBiological ModelsBiophysical ProcessBrainBrain Nervous SystemCardiac ArrhythmiaCell Communication and SignalingCell SignalingChemicalsCyclic NucleotidesDevelopmentDiseaseDisorderDysfunctionElementsEncephalonEngineering / ArchitectureEpilepsyEpileptic SeizuresEpilepticsExhibitsFluorometryFunctional disorderHeartHeart ArrhythmiasHigh temperature of physical objectIntracellular Communication and SignalingIntracellular Second MessengerIon ChannelIon Channel GatingIon Channel GatingsIonic ChannelsLengthLifeLigand BindingLigandsMeasuresMembraneMembrane ChannelsModel SystemModelingMolecularMolecular InteractionMolecular ProbesMuscleMuscle TissuePhysiopathologyPropertyProtein DynamicsProteinsReceptor ProteinRegulationSecond Messenger SystemsSecond MessengersSeizure DisorderSignal TransductionSignal Transduction SystemsSignalingSpectroscopySpectrum AnalysesSpectrum AnalysisStimulusStructureTemperatureTemperature SenseTestingThermodynamicThermodynamicsbiological signal transductionbiophysical mechanismdevelopmentaldriving forcedrug developmentepilepsiaepileptogenichigh temperaturehigh throughput analysisinsightmembermembrane structuremuscularmutantnew approachesnew drug targetnew drug treatmentsnew druggable targetnew drugsnew pharmacological therapeuticnew pharmacotherapy targetnew therapeutic targetnew therapeuticsnew therapynew therapy targetnext generation therapeuticsnovel approachesnovel drug targetnovel drug treatmentsnovel druggable targetnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel pharmacotherapy targetnovel strategiesnovel strategynovel therapeutic targetnovel therapeuticsnovel therapynovel therapy targetpathophysiologyreceptorreconstructionresponsesignal transduction second messengerssimulationsingle moleculesupercomputertemperature sensationthermoreceptiontoolvoltagevoltage clampwaveguide
Description preview
Project Summary
Members of the voltage-gated ion channels (VGICs) are critical for electrical and chemical signaling throughout
the three kingdoms of life. Dysfunction of ion channels underlie a wide range of pathophysiology and they are
one of the primary targets for new drug development. Although they share a common membrane architecture,
the…
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