grant
Biophysical force affects type 1 alveolar epithelial cell-mediated regulation of the pulmonary matrisome and lung development
Organization UT SOUTHWESTERN MEDICAL CENTERLocation DALLAS, UNITED STATESPosted 15 Sept 2024Deadline 31 Aug 2029
NIHUS FederalResearch GrantFY202520S Catalytic Proteasome20S Core Proteasome20S Proteasome20S ProteosomeAcuteAddressAdvisory CommitteesAffectAirAlveolarArchitectureAttenuatedBioinformaticsBiophysicsBlood capillariesBone-Derived Transforming Growth FactorBreathingBronchopulmonary DysplasiaCausalityCell BodyCell CommunicationCell Communication and SignalingCell CompartmentationCell CompartmentationsCell FunctionCell InteractionCell LineageCell PhysiologyCell ProcessCell ReprogrammingCell SignalingCell modelCell to Cell Communication and SignalingCell-Cell SignalingCell-Extracellular MatrixCell-to-Cell InteractionCellsCellular FunctionCellular PhysiologyCellular ProcessCellular biologyCellular modelChildren's HospitalClinicalClinical ResearchClinical StudyCommunicationCompetenceCritical PathsCritical PathwaysDNA Molecular BiologyDataDevelopmentDevelopmental BiologyDiseaseDisorderECMEducational workshopEmbryoEmbryonicEngineering / ArchitectureEnvironmentEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessEpithelial CellsEquilibriumEtiologyExposure toExtracellular MatrixFundingFutureGasesGene ExpressionGene TranscriptionGeneralized GrowthGenerationsGenetic TranscriptionGoalsGrowthHealthHyperoxiaImpairmentIn VitroIncidenceInfantInjuryIntegrinsIntegrins Extracellular MatrixIntracellular Communication and SignalingInvestigatorsLaboratoriesLigandsLungLung Alveolar EpitheliaLung DiseasesLung Respiratory SystemLung damageLung tissue regenerationMacropainMacroxyproteinaseMapsMechanical StressMechanical ventilationMediatingMentorshipMiceMice MammalsMilk Growth FactorModelingMolecularMolecular BiologyMotionMulticatalytic ProteinaseMurineMusNational Institutes of HealthNatural regenerationNeonatal lungNeonatologyOxidative StressPathogenesisPathologicPatientsPediatric HospitalsPennsylvaniaPhenotypePhiladelphiaPhysiciansPlatelet Transforming Growth FactorPremature Infant DiseasesProcessProductionProductivityProgram DevelopmentProsomeProteasomeProteasome Endopeptidase ComplexProteosomePulmonary DiseasesPulmonary DisorderPulmonary HypertensionRNA ExpressionReceptor ProteinRegenerationRegulationRegulatory ProteinResearchResearch PersonnelResearchersResistanceRespiratory AspirationRespiratory InspirationRiskRoleScientistSeveritiesSignal PathwaySignal TransductionSignal Transduction SystemsSignalingStressStretchingSubcellular ProcessTGF BTGF-betaTGF-βTGFbetaTGFβTask ForcesTestingTherapeuticThickThicknessTissue GrowthTrainingTraining ProgramsTranscriptionTransforming Growth Factor betaTransforming Growth Factor-Beta Family GeneTransgenic MiceTranslatingUnited States National Institutes of HealthUniversitiesUpregulationVentilatorWorkWorkshopadvisory teamalveolar epitheliumattenuateattenuatesbalancebalance functionbasebasesbiological signal transductionbiophysical foundationbiophysical principlesbiophysical sciencescapillarycareercareer developmentcausationcell biologycellular reprogrammingchronic lung disease in infantschronic lung disease in neonatal infantschronic lung disease in neonateschronic lung disease in newbornschronic lung disease in prematuritychronic lung disease in preterm infantschronic lung disease of infancychronic lung disease of prematurityco-morbidco-morbiditycomorbiditydevelopmentaldisease causationdisease of the lungdisorder of the lungepigeneticallyextreme prematurityextremely premature infantextremely pretermextremely preterm infantgenetic regulatory proteinglobal gene expressionglobal transcription profilehyperoxygenationin vitro Modelin vivoinfant chronic lung diseaseinfants with chronic lung diseaseinjuriesinnovateinnovationinnovativeinsightinspirationinstructorintercellular communicationlife spanlifespanlung developmentlung disorderlung injurylung regenerationlymphatic dysfunctionlymphatic impairmentmechanical respiratory assistmechanically ventilatedmembermouse modelmulticatalytic endopeptidase complexmurine modelneonatal chronic lung diseaseneonatal miceneonatal pulmonaryneonatenewborn chronic lung diseasenewborn lungnewborn pulmonarynovelontogenypediatric departmentpost-prematurity respiratory diseasepotential biological markerpotential biomarkerprematureprematuritypreterm infants with chronic lung diseasepreventpreventingprogramspulmonarypulmonary damagepulmonary injurypulmonary regenerationpulmonary tissue damagepulmonary tissue injuryreceptorregenerateregulatory gene productresistantresponsescATAC sequencingscATAC-seqscRNA sequencingscRNA-seqsingle cell ATAC-seqsingle cell ATAC-sequencingsingle cell Assay for Transposase Accessible Chromatin sequencingsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell sequencing assay for transposase accessible chromatinsingle cell transcriptomic profilingsingle-cell Assay for Transposase-Accessible Chromatin with sequencingsingle-cell RNA sequencingsingle-cell assay for transposase-accessible chromatin using sequencingsingle-cell assay for transposase-accessible chromatin-seqsocial rolesuccesstranscriptometranscriptomicsvery prematurevery preterm
Description preview
PROJECT SUMMARY/ABSTRACT
This proposal delineates a five-year individualized training plan that will promote an independent
scientific career to study the pathogenesis of bronchopulmonary dysplasia (BPD), which is the most common
sequalae of prematurity and impacts the patient throughout the lifespan. Specifically, the scientific program of
the…
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