grant
Biomolecular Recognition with Synthetic Protein Mimics
Organization NEW YORK UNIVERSITYLocation NEW YORK, UNITED STATESPosted 1 Feb 2019Deadline 31 Jan 2029
NIHUS FederalResearch GrantFY2026Antigenic DeterminantsBindingBinding DeterminantsBiologicalBiological FunctionBiological ProcessCell Communication and SignalingCell SignalingComplexDevelopmentDiseaseDisorderDouble-Stranded RNAEngineeringEpitopesEventFoundationsGene Action RegulationGene Expression RegulationGene RegulationGene Regulation ProcessIDPInosine DiphosphateInosine PyrophosphateIntracellular Communication and SignalingLigandsMediatingMembrane Protein GeneMembrane ProteinsMembrane-Associated ProteinsMolecularMolecular InteractionNon-Polyadenylated RNAPeptide DomainProtein DomainsProtein InhibitionProteinsRNARNA Gene ProductsRNA and protein interactionRNA-Protein InteractionReceptor ProteinResearchRibonucleic AcidRiboxinRiboxineSignal PathwaySignal TransductionSignal Transduction SystemsSignalingStructureSurface ProteinsTertiary Protein StructureTherapeuticTherapeutic AgentsTherapeutic InterventionWorkbiologicbiological signal transductiondevelopmentaldsRNAinhibit proteininhibit proteinsintervention therapymolecular sizeprotein complexprotein inhibitionsprotein protein interactionrational designreceptorscaffoldscaffoldingsmall moleculesynthetic proteintherapeutic candidatetherapeutic target
Description preview
Abstract
Interactions of proteins with other biomolecules regulate fundamental cellular events and misregulation of these
interactions leads to disease states. Proteins often utilize small folded domains for recognition of other
biomolecules. The basic hypothesis guiding our research is that by mimicking these folded domains we can
specifically…
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