grant
Biomarkers for parkinsonian disorders in CNS-originating extracellular vesicles
Organization UNIVERSITY OF CALIFORNIA LOS ANGELESLocation LOS ANGELES, UNITED STATESPosted 1 Apr 2023Deadline 31 Mar 2028
NIHUS FederalResearch GrantFY2026Accuracy of DiagnosisAddressAgreementAmentiaAnxietyAtypical Parkinson disorderAutonomic DysfunctionAutopsyBehavior DisordersBiochemicalBiological MarkersBloodBlood PlasmaBlood Reticuloendothelial SystemBlood SerumBlood TestsBrainBrain Nervous SystemCALL proteinCNS DiseasesCNS Nervous SystemCNS disorderCamL1 Gene ProductCare GiversCaregiversCell BodyCell Surface Glycoprotein L1CellsCentral Nervous SystemCentral Nervous System DiseasesCentral Nervous System DisordersCerebrospinal FluidCessation of lifeClinicClinicalClinical TrialsConfusionConfusional StateConsultCyclicityDLBDataDeathDegenerative Neurologic DisordersDementiaDementia with Lewy BodiesDevelopmentDiagnosisDiagnostic testsDiseaseDisease ProgressionDisorderDysautonomia-Orthostatic Hypotension SyndromeDysautonomic Orthostatic HypotensionDyskinesia SyndromesEncephalonF11 GlycoproteinFamilyFast-Wave SleepFutureGoalsHematologic TestsHematological TestsHematology TestingImmune PrecipitationImmunoprecipitationInterventionL1 Cell Adhesion MoleculeL1CAMLeadLeftLightLumbar PunctureMAC393 antigenMT-bound tauMeasuresMental ConfusionMethodologyModelingMovement Disorder SyndromesMovement DisordersMultiple System AtrophyMultiple System Atrophy SyndromeMultisystem AtrophyMultisystemic AtrophyNAC precursorNGF-Inducible GlycoproteinNILE GlycoproteinNILE ProteinNatureNerve CellsNerve Growth Factor-Inducible Large External GlycoproteinNerve UnitNervous System Degenerative DiseasesNeural Adhesion Molecule L1Neural CellNeural Cell Adhesion Molecule L1Neural Degenerative DiseasesNeural degenerative DisordersNeuraxisNeurocyteNeurodegenerative DiseasesNeurodegenerative DisordersNeurologicNeurologic Degenerative ConditionsNeurologicalNeurologistNeuronsNew YorkOligoOligonucleotidesPARK1 proteinPARK4 proteinPETPET ScanPET imagingPETSCANPETTParadoxical SleepParalysis AgitansParkinsonParkinson DiseaseParkinson plus syndromesParkinsonianParkinsonian ConditionParkinsonian DiseasesParkinsonian DisordersParkinsonian SyndromeParkinsonismPathologicPatientsPb elementPeriodicityPhotoradiationPhysiciansPlasmaPlasma SerumPositron Emission Tomography Medical ImagingPositron Emission Tomography ScanPositron-Emission TomographyPrimary ParkinsonismProgressive Supranuclear OphthalmoplegiaProgressive Supranuclear PalsyProtocolProtocols documentationPublic HealthREM SleepRad.-PETRadioactive IsotopesRadioisotopesRadionuclidesReportingResearchResearch DesignReticuloendothelial System, Serum, PlasmaRhombencephalic SleepRhythmicitySGP-2 proteinSGP2SNCASNCA proteinSP 40,40 proteinSPECTSPECT imagingSamplingSampling StudiesSensitivity and SpecificitySerumShy-Drager SyndromeShy-Drager Type Idiopathic Orthostatic HypotensionSingle-Photon Emission-Computed Radionuclide TomographySpecialistSpecificitySpinal PunctureSteele-Richardson-Olszewski DiseaseSteele-Richardson-Olszewski SyndromeStressStudy TypeSymptomsTRPM-2 proteinTRPM2TauopathiesTestingTrainingTranslatingUniversitiesValidationX-ray-inducible protein 8XIP8 proteina-syna-synucleinalpha synucleinalpha synuclein genealphaSP22apoJ proteinapolipoprotein Jasynatypical parkinsonian disorderatypical parkinsonian syndromeatypical parkinsonismbehavioral disorderbio-markersbiobankbiologic markerbiomarkerbiomarker arraybiomarker panelbiomarker performancebiomarker utilitybiorepositorybrain tissuecandidate biomarkercandidate markercerebral spinal fluidclusterincohortcomplement lysis inhibitorcomplement-associated protein SP-40,40 proteinconsultscortico-basal syndromecorticobasal syndromecost effectivedegenerative diseases of motor and sensory neuronsdegenerative neurological diseasesdevelopmentaldiagnostic abilitydiagnostic accuracydiagnostic capabilitydiagnostic powerdiagnostic tooldiagnostic utilitydiagnostic valuedreaming sleepeffective therapyeffective treatmentexperienceextracellular vesiclesheavy metal Pbheavy metal leadimaging biomarkerimaging markerimaging-based biological markerimaging-based biomarkerimaging-based markerimprovedinclusion criteriaionizing radiation-induced protein-8liquid biopsymarker panelmicrotubule bound taumicrotubule-bound tauminimally invasivenecropsyneurodegenerative illnessneurofilamentneuronalneuropathologic tauneuropathological taunon A-beta component of AD amyloidnon A4 component of amyloid precursoroligospatient responsepatient specific responsepatient stratificationpositron emission tomographic (PET) imagingpositron emission tomographic imagingpositron emitting tomographypostmortemprospectiverapid eye movement sleepresponsive patientsingle photon emission computed tomographyspinal fluidstratified patientstudy designsuccesssulfated glycoprotein 2synucleinopathytautau Proteinstau associated neurodegenerationtau associated neurodegenerative processtau driven neurodegenerationtau factortau induced degenerationtau induced neurodegenerationtau mediated neurodegenerationtau neurodegenerative diseasetau neuropathologytau pathologytau pathophysiologytau proteinopathytau related neurodegenerationtau-induced pathologytauopathic neurodegenerative disordertauopathytestosterone-repressed prostate message-2 proteinvalidationsα synuclein geneα-synα-synucleinτ Proteins
Description preview
Summary
Many cases of Parkinson’s disease, and even more so atypical parkinsonian disorders, are misdiagnosed.
Misdiagnosis not only causes high stress and anxiety to patients, their families, and their caregivers, but also is
a major impediment to development of effective therapy for these diseases. Recently, we have demonstrated
that the…
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