grant
Biomarker validation for intraductal papillary mucinous neoplasms of the pancreas
NIHUS FederalResearch GrantFY2025AbscissionAccuracy of DiagnosisActive Follow-upAssayBioassayBiological AssayBody TissuesCancersCarcinomaCharacteristicsChemopreventionClinicalColloidsCystCyst FluidCystic NeoplasmCystic TumorDataDevelopmentDiagnosticDiseaseDisorderDouble-Blind MethodDouble-Blind StudyDouble-BlindedDouble-Masked MethodDouble-Masked StudyDuctDuct (organ) structureDysplasiaEmotionalEpithelial cancerEpitheliumEvaluationExcisionExtirpationFinancial costGene ExpressionGenesGoalsHigh grade dysplasiaHistologicHistologicallyImaging technologyInflammationInterventionIntestinalIntestinesLaboratoriesLesionLinkMalignantMalignant - descriptorMalignant Epithelial NeoplasmsMalignant Epithelial TumorsMalignant NeoplasmsMalignant Pancreatic NeoplasmMalignant TumorMalignant neoplasm of pancreasMeasuresMinorityModelingModerate DysplasiaMolecularMorbidityMorbidity - disease rateMucinous NeoplasmMucinous TumorNomogramsPancreas AdenocarcinomaPancreas CancerPancreas CystPancreas NeoplasmsPancreas TumorPancreatic AdenocarcinomaPancreatic CancerPancreatic CystPancreatic TumorPancreatic cystic neoplasiaPapillaryPathway interactionsPatient riskPatientsPersonsPilot ProjectsPlacebosPopulationPreventionPrevention trialProspective StudiesProteinsProteomicsPublishingRadiographyRandomizedRemovalResearch ResourcesResectedResourcesRiskRoentgenographySamplingSham TreatmentSurgical RemovalTechnologyTestingTimeTissuesValidationWorkactive followuparmaspirateassay developmentbiomarker arraybiomarker developmentbiomarker panelbiomarker validationbowelcancer invasivenesscomputer based predictioncurative interventioncurative therapeuticcurative therapycurative treatmentsdepositorydesigndesigningdevelopmentaldiagnostic abilitydiagnostic accuracydiagnostic capabilitydiagnostic powerdiagnostic utilitydiagnostic valuedifferential expressiondifferentially expresseddigitaldisease riskdisorder riskdyscrasiaepithelial carcinomafollow upfollow-upfollowed upfollowupglobal gene expressionglobal transcription profilehigh riskimprovedmalignancymarker panelmarker validationmonetary costmortalityneoplasm/cancernew technologynovelnovel technologiesoperationoperationspancreatic cystic lesionspancreatic cystic neoplasmspancreatic cystic tumorspancreatic malignancypancreatic neoplasiapancreatic neoplasmpathwaypilot studypredictive modelingprotein biomarkersprotein expressionprotein markersradiological imagingrandomisationrandomizationrandomly assignedrepositoryresectionsham therapyspatial RNA sequencingspatial gene expression analysisspatial gene expression profilingspatial resolved transcriptome sequencingspatial transcriptome analysisspatial transcriptome profilingspatial transcriptome sequencingspatial transcriptomicsspatially resolved transcriptomicsspatio transcriptomicstranscriptional differencestranscriptometranscriptomicsvalidations
Description preview
PROJECT SUMMARY/ABSTRACT: Intraductal papillary mucinous neoplasms (IPMN) of the
pancreas are cystic tumors that represent a radiographically identifiable precursor lesion of
pancreatic cancer. Currently, IPMN represent our best opportunity for intervention - and
interception - prior to the development of an incurable cancer. The challenge…
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