grant
Biomarker Core
Organization COLUMBIA UNIVERSITY HEALTH SCIENCESLocation NEW YORK, UNITED STATESPosted 15 Jun 2020Deadline 30 Apr 2030
NIHUS FederalResearch GrantFY2025AD dementiaAD related dementiaADRDAI systemAPLP1APLP1 geneAlzheimer Type DementiaAlzheimer disease dementiaAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's DiseaseAlzheimer's and related dementiasAlzheimer's dementia and related dementiaAlzheimer's dementia or related dementiaAlzheimer's disease and related dementiaAlzheimer's disease and related disordersAlzheimer's disease or a related dementiaAlzheimer's disease or a related disorderAlzheimer's disease or related dementiaAlzheimer's disease related dementiaAlzheimers DementiaAmentiaAmyloidAmyloid SubstanceArtificial IntelligenceAstroproteinBasic Fibroblast Growth FactorBasic Fibroblast Growth Factor GeneBiologicalBiological MarkersBloodBlood PlasmaBlood Reticuloendothelial SystemBlood VesselsBrain VascularC1 qC1qCerebrospinal FluidClinicalClinical ResearchClinical StudyClinical TrialsCognitive agingComplementComplement 1qComplement C1qComplement ProteinsComputer ReasoningDataData BasesDatabasesDementiaDependenceDevelopmentDiseaseDisorderEndosomesEthnic GroupEthnic OriginEthnic PeopleEthnic PopulationEthnic individualEthnicityEthnicity PeopleEthnicity PopulationFGF-2FGF2FGF2 geneFGFBFibroblast Growth Factor 2Fibroblast Growth Factor 2 GeneFoundationsFundingGFA-ProteinGFAPGlial Fibrillary Acid ProteinGlial Fibrillary Acidic ProteinGlial Intermediate Filament ProteinGoalsGrantHBGF-2Heparin-Binding Growth Factor 2Heparin-Binding Growth Factor Class IIHeterogeneityImmune MarkersImmune responseImmunologic MarkersInflammatoryInternationalInvestigatorsLeadLeadershipLesionLiquid substanceMR ImagingMR TomographyMRIMRI ScansMRIsMT-bound tauMachine IntelligenceMagnetic Resonance ImagingMagnetic Resonance Imaging ScanMeasurementMedical Imaging, Magnetic Resonance / Nuclear Magnetic ResonanceMethodsMissionMolecularNMR ImagingNMR TomographyNerve DegenerationNeuron DegenerationNuclear Magnetic Resonance ImagingPETPET ScanPET imagingPETSCANPETTPGF genePLGF-2ParticipantPathogenesisPathologicPathway interactionsPb elementPlGFPlGF proteinPlacental Growth FactorPlasmaPlasma SerumPopulation HeterogeneityPositron Emission Tomography Medical ImagingPositron Emission Tomography ScanPositron-Emission TomographyPrimary Senile Degenerative DementiaProcessProstate Epithelial Cell Growth FactorProtocolProtocols documentationPublicationsRaceRacesRacial GroupRad.-PETReceptosomesResearchResearch PersonnelResearchersReticuloendothelial System, Serum, PlasmaSamplingScientific PublicationScientistTestingThickThicknessTrainingVEGFVEGFsVascular Endothelial Growth FactorsWorkZeugmatographybFGFbio-markersbiologicbiologic markerbiomarkercerebral spinal fluidcerebral vascularcerebro-vascularcerebrovascularcomplementationdata basedevelopmentaldiverse populationsethnic subgroupethnicity groupfluidheavy metal Pbheavy metal leadheterogeneous populationhost responseimaging biomarkerimaging markerimaging-based biological markerimaging-based biomarkerimaging-based markerimmune system responseimmune-based biomarkersimmunological biomarkersimmunological markersimmunoresponseimprovedinsightinstrumentationinterestliquidmicrotubule bound taumicrotubule-bound tauneural degenerationneural imagingneural inflammationneuro-imagingneurodegenerationneurodegenerativeneuroimagingneuroimaging biomarkerneuroimaging markerneuroinflammationneuroinflammatoryneurological degenerationneurological imagingneuronal degenerationnew markernext generationnovelnovel biomarkernovel markerparticipant enrollmentpathwaypatient enrollmentplacenta growth factorpopulation diversitypositron emission tomographic (PET) imagingpositron emission tomographic imagingpositron emitting tomographypre-clinical studypreclinical studyprimary degenerative dementiaproduct placenta growth factorracialracial backgroundracial originracial populationracial subgroupresponsesenile dementia of the Alzheimer typespinal fluidsuccesstautau Proteinstau factortooltraffickingtraining opportunityvascularτ Proteins
Description preview
BIOMARKER CORE SUMMARY
Analysis of cerebrospinal fluid (CSF), positron emission tomography (PET), magnetic resonance imaging (MRI),
and now, blood, allow operational measurement of amyloid, tau, and neurodegeneration (ATN), the major
pathophysiological changes that define Alzheimer’s disease (AD). Moreover, improved instrumentation and…
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