grant
Biological role and pharmacology of EXPERA family proteins and their effect onsterol homeostasis
NIHUS FederalResearch GrantFY2025AD dementiaAddressAffinityAlzheimer Type DementiaAlzheimer disease dementiaAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's DiseaseAlzheimers DementiaAssayAutomobile DrivingAutoregulationBindingBioassayBiologicalBiological AssayBiological FunctionBiological ProcessBody TissuesCancersCardiovascular DiseasesCholesterolCholesterol HomeostasisClinicalCloningCodeCoding SystemComplexDNA mutationDevelopmentDiseaseDisorderDockingEventFamilyGenesGenetic ChangeGenetic defectGenetic mutationHepatic DisorderHomeostasisKnowledgeLDL ReceptorsLDLR geneLigand BindingLigandsLipidsLipoprotein LDL ReceptorsLiver diseasesLow Density Lipoprotein ReceptorMalignant NeoplasmsMalignant TumorMembraneMembrane Protein GeneMembrane ProteinsMembrane-Associated ProteinsMetabolic DiseasesMetabolic DisorderMetabolic dysfunctionMolecularMolecular InteractionMutationNAFLDOrganism-Level ProcessOrganismal ProcessPharmacologyPhysiologic ProcessesPhysiological HomeostasisPhysiological ProcessesPlayPrebeta-LipoproteinsPrimary Senile Degenerative DementiaProtein FamilyProteinsReceptor ProteinRegulationResearchRoleSterolsStressStructureSurface ProteinsTechniquesTherapeuticTherapeutic InterventionThesaurismosisTissuesVLDLVLDL LipoproteinsVery low density lipoproteinbiologiccardiovascular disordercholesterol metabolismchronic hepatic diseasechronic hepatic disorderchronic liver diseasechronic liver disorderdevelopmentaldrivingfat metabolismgenome mutationhepatic diseasehepatopathyimprovedinsightinterestintervention therapylipid metabolismliver disordermalignancymembermembrane structuremetabolism disorderneoplasm/cancerneuropathic painnon-alcohol fatty liver diseasenon-alcoholic fatty liver diseasenon-alcoholic liver diseasenonalcoholic fatty liver diseasenovelpainful neuropathypharmacologicprimary degenerative dementiaprotein homeostasisproteostasisreceptorresponsesenile dementia of the Alzheimer typesigma-2 receptorsocial rolestructural biologysuccesstargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttherapeutic targettraffickingvirtual
Description preview
Abstract
EXPERA are a family of membrane proteins that include sigma-2 receptor and TM6SF2, both of which play
crucial yet understudied roles in cholesterol metabolism and disease. Sigma-2, an enigmatic membrane receptor
implicated in cancer, Alzheimer’s disease, and neuropathic pain, has attracted significant pharmacological
interest due to its…
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