grant
Biological and lifestyle factors contributing to Tau in women at risk for Alzheimer's disease.
Organization UNIVERSITY OF CALIFORNIA, SAN DIEGOLocation LA JOLLA, UNITED STATESPosted 15 Sept 2023Deadline 31 May 2028
NIHUS FederalResearch GrantFY2025(TNF)-αAD dementiaAD pathologyAccelerationAddressAdverse effectsAlzheimer Type DementiaAlzheimer disease dementiaAlzheimer risk factorAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's DiseaseAlzheimer's Disease PathwayAlzheimer's biomarkerAlzheimer's disease biological markerAlzheimer's disease pathologyAlzheimer's disease riskAlzheimer's pathologyAlzheimers DementiaAlzheimer’s biological markerAlzheimer’s disease biomarkerAnti-InflammatoriesAnti-Inflammatory AgentsAnti-inflammatoryAssayAutoimmune DiseasesB cell differentiation factorB cell stimulating factor 2B-Cell Differentiation FactorB-Cell Differentiation Factor-2B-Cell Stimulatory Factor-2BCDFBSF-2BSF2BioassayBiologic FactorBiologicalBiological AssayBiological FactorsBrainBrain Nervous SystemCD 120b AntigenCD120b AntigensCNS Nervous SystemCachectinCentral Nervous SystemCerebrospinal FluidCognitionCognitiveCognitive DisturbanceCognitive ImpairmentCognitive declineCognitive deficitsCognitive function abnormalDataData CollectionDifferences between sexesDiffers between sexesDiseaseDisease OutcomeDisorderDisturbance in cognitionDrug TherapyEncephalonEndocrineEndocrine Gland SecretionEnrollmentFemaleFundingGeneticGenetic RiskGonadal Steroid HormonesHPGFHealthHepatocyte-Stimulating FactorHigh Risk WomanHormonesHybridoma Growth FactorIFN-beta 2IFNB2IL-6IL6 ProteinImmuneImmune responseImmunesImpaired cognitionIndividualInflammationInflammatoryInflammatory ResponseInterleukin-6InvestigationJointsKnowledgeLifeLife StyleLife Style ModificationLifestyleLinkMGI-2MT-bound tauMacrophage-Derived TNFMeasuresMediatingMemoryMenopauseModelingMonocyte-Derived TNFMyeloid Differentiation-Inducing ProteinNational Institutes of HealthNeuraxisNon-pharmacologic TherapyNonpharmacologic InterventionNonpharmacologic TherapyNonpharmacologic approachNonpharmacologic treatmentObservation researchObservation studyObservational StudyObservational researchObstructive Sleep ApneaOutcomePETPET ScanPET imagingPETSCANPETTParticipantPathogenesisPathologicPathologyPathway interactionsPerformancePharmacological TreatmentPharmacotherapyPhysical activityPhysical assessmentPilot ProjectsPlasmacytoma Growth FactorPlayPositron Emission Tomography Medical ImagingPositron Emission Tomography ScanPositron-Emission TomographyPredispositionPrimary Senile Degenerative DementiaProteinsRad.-PETReceptor ProteinReceptors, Tumor Necrosis Factor, Type IIReportingReproductive FactorsReproductive HistoryReproductive History EpidemiologyReproductive IssuesResearch PriorityRisk FactorsRisk ReductionRoleSample SizeSamplingSedentary behaviorSedentary life-styleSeveritiesSex DifferencesSex HormonesSex Steroid HormonesSexual differencesSleepStressSusceptibilitySymptomsSyndrome, Sleep Apnea, ObstructiveTM-MKRTNFTNF ATNF AlphaTNF geneTNF-R2TNF-RIITNF-αTNFATNFBRTNFR p75TNFR2TNFR80TNFRSF1BTNFRSF1B ReceptorTNFRSF1B geneTNFαTauopathiesTestosteroneTherapeutic HormoneTherapeutic TestosteroneTimeTrans-TestosteroneTumor MarkersTumor Necrosis FactorTumor Necrosis Factor Beta ReceptorTumor Necrosis Factor Receptor 2Tumor Necrosis Factor Receptor 75Tumor Necrosis Factor Receptor Type 2Tumor Necrosis Factor-alphaUnited States National Institutes of HealthWomanWorkabnormally aggregated tau proteinalzheimer riskassociated symptomat-risk femalesat-risk womenautoimmune conditionautoimmune disorderautoimmunity diseasebiologiccerebral spinal fluidco-morbid symptomco-occuring symptomcognitive defectscognitive dysfunctioncognitive functioncognitive losscomorbid symptomcomparing females and malescomparing women and menconcurrent symptomcooccuring symptomcytokinediet and exercisedisparities in sexdrug interventiondrug treatmentenrollexperiencefemales at high riskfemales compared to malesfemales compared with malesfemales versus malesfemales vs. malesfilamentous tau inclusionfollow up assessmentfollowup assessmentgonadal steroidshigh risk femaleshost responseimmune system responseimmunoresponseimprovedinterferon beta 2life style interventionlife-style factorlifestyle factorslifestyle interventionlifestyle modificationmalleable riskmenmicrotubule associated protein tau aggregationmicrotubule associated protein tau depositmicrotubule bound taumicrotubule-bound taumild cognitive disordermild cognitive impairmentmodifiable riskneural imagingneural inflammationneuro-imagingneuroimagingneuroinflammationneuroinflammatoryneurological imagingneuropathologic tauneuropathological taunon-drug therapynon-drug treatmentnondrug therapynondrug treatmentolder womenp-taup-τpaired helical filament of taupathwaypharmaceutical interventionpharmacological interventionpharmacological therapypharmacology interventionpharmacology treatmentpharmacotherapeuticsphospho-tauphospho-τphosphorylated taupilot studypositron emission tomographic (PET) imagingpositron emission tomographic imagingpositron emitting tomographypost-translational modification of tauposttranslational modification of tauprimary degenerative dementiareceptorrecruitreduce riskreduce risksreduce that riskreduce the riskreduce these risksreduces riskreduces the riskreducing riskreducing the riskrisk-reducingsedentary lifestyleself-aggregate tausenile dementia of the Alzheimer typesexsex based differencessex disparitysex steroidsex-dependent differencessex-related differencessex-specific differencessocial rolespinal fluidsymptom associationsymptom comorbiditytautau PHFtau Proteinstau accumulationtau aggregatetau aggregationtau associated neurodegenerationtau associated neurodegenerative processtau driven neurodegenerationtau factortau fibrillizationtau filamenttau functiontau induced degenerationtau induced neurodegenerationtau mediated neurodegenerationtau neurodegenerative diseasetau neurofibrillary tangletau neuropathologytau oligomertau paired helical filamenttau pathologytau pathophysiologytau phosphorylationtau polymerizationtau posttranslational modificationtau proteinopathytau related neurodegenerationtau-1tau-induced pathologytau-tau interactiontauopathic neurodegenerative disordertauopathytherapeutic targettumor biomarkertumor necrosis factor receptor superfamily, member 1Btumor specific biomarkerwomen at high riskwomen compared to menwomen compared with menwomen versus menwomen vs. menτ Proteinsτ aggregationτ functionτ phosphorylation♀
Description preview
PROJECT SUMMARY/ABSTRACT Growing evidence reports that women show a more aggressive profile of
Alzheimer's disease (AD) than men with greater pathological tau burden and steeper cognitive decline; yet the
reasons for these sex differences are poorly understood. Sex differences in AD point to sex-disparate causal
pathways as well as sex-specific…
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