grant
Bioengineering adipocytes for cancer therapy
Organization UNIVERSITY OF CALIFORNIA, SAN FRANCISCOLocation SAN FRANCISCO, UNITED STATESPosted 1 Apr 2024Deadline 31 Mar 2029
NIHUS FederalResearch GrantFY2025AbdomenAbscissionAdipocytesAdipose CellAdipose tissueAdjuvantAppetiteAreaAspiration LipectomyAspiration LipolysisAssayBRCA 1/2 mutationsBRCA mutantsBRCA mutationsBRCA1 MutationBRCA1 gene mutationBRCA1/2 mutationsBRCA1/2mutBRCAmutBioassayBiological AssayBiological FunctionBiological ProcessBiomedical EngineeringBittner VirusBody TissuesBreastBreast CancerBreast Cancer ModelBreast Cancer PatientBreast NeoplasmsBreast TissueBreast Tumor PatientBreast TumorsBreast tumor modelBrown Adipose TissueBrown FatCAR T cellsCAR modified T cellsCAR-TCAR-TsCRISPR activationCRISPR activatorCRISPR based activationCRISPR gene activationCRISPR transcription activationCRISPR transcriptional activationCRISPR-Cas-9-mediated gene activationCRISPR-based gene activationCRISPR-dCAS9 ActivatorCRISPR-mediated transcriptional activationCRISPR/CAS9 activationCRISPR/CAS9 gene activationCRISPR/dCas9 activationCRISPR/dCas9-based transcriptional activationCRISPRaCancer ModelCancer PatientCancer TreatmentCancer cell lineCancerModelCancersCell BodyCell Culture TechniquesCell Growth in NumberCell LineCell MultiplicationCell ProliferationCell TherapyCell modelCellLineCellsCellular ProliferationCellular modelClinicalCo-cultureCocultivationCocultureCoculture TechniquesColonContra-lateral BreastContralateral BreastD-GlucoseDesire for foodDextroseER PositiveER+EndocrineEnergy ExpenditureEnergy MetabolismEngineeringEstrogen receptor positiveExcisionExtirpationFat CellsFatsFatty TissueFatty acid glycerol estersFemaleGene CombinationsGeneralized GrowthGenesGeneticGenetic ModelsGenetic Models for CancerGlucoseGlycolysisGrowthHemostasisHemostatic functionHeterograftHeterologous TransplantationHibernating GlandHormone secretionHumanHumulin RHypoxiaHypoxicImmunodeficient MouseImplantInsulinIntestinalIntestinesLipidsLipocytesLiposuctionLiverMMTVMalignant Breast NeoplasmMalignant CellMalignant Neoplasm TherapyMalignant Neoplasm TreatmentMalignant NeoplasmsMalignant Pancreatic NeoplasmMalignant TumorMalignant neoplasm of pancreasMalignant neoplasm of prostateMalignant prostatic tumorMammary CancerMammary Cancer VirusMammary Gland ParenchymaMammary Gland TissueMammary NeoplasmsMature LipocyteMature fat cellMeasuresMetastasisMetastasis to the LungMetastasizeMetastatic LesionMetastatic MassMetastatic NeoplasmMetastatic Neoplasm to the LungMetastatic TumorMetastatic Tumor to the LungMiceMice MammalsModern ManMouse Mammary Tumor VirusMurineMusNeoplasm MetastasisNovolin ROperative ProceduresOperative Surgical ProceduresOrganOrganoidsOutcomeOxygen ConsumptionOxygen DeficiencyPancreasPancreas CancerPancreaticPancreatic CancerPathway interactionsPhenotypePlastic Surgical ProceduresProceduresProcessProliferatingPropertyProstateProstate CAProstate CancerProstate GlandProstate malignancyProstatic GlandPyMTRecurrenceRecurrentRegular InsulinRemovalResearch ResourcesResectedResourcesSecondary NeoplasmSecondary TumorSourceStrains Cell LinesSuction LipectomySuction LipolysisSurgicalSurgical InterventionsSurgical ProcedureSurgical RemovalT cells for CARTNBCTestingTherapeuticTissue GrowthTissuesTransplantationTumor CellTumor TissueUpregulationWorkXenograftXenograft procedureXenotransplantationactivating CRISPR technologyadiposeangiogenesisanti-cancer therapybio-engineeredbio-engineersbioengineeringbiological engineeringbowelcancer cellcancer geneticscancer metastasiscancer predispositioncancer progressioncancer sub-typescancer subtypescancer therapycancer typecancer-directed therapycell based interventioncell culturecell culturescell mediated interventioncell mediated therapiescell-based therapeuticcell-based therapycellular therapeuticcellular therapychimeric antigen T cell receptorchimeric antigen receptor (CAR) T cellschimeric antigen receptor Tchimeric antigen receptor T cellschimeric antigen receptor fusion protein T-cellschimeric antigen receptor modified T cellscultured cell linedrug developmentfat metabolismglucose metabolismglucose transportglucose uptakehepatic body systemhepatic organ systemhormonal secretionindividuals with breast cancerinnovateinnovationinnovativelipid metabolismlung metastasismalignancymalignant breast tumormammary cancer modelmammary tumormammary tumor modelmetabolic profilemetastasize to the lungmilk agentmouse geneticsmouse modelmurine modelmutations in BRCAneoplasm progressionneoplasm/cancerneoplastic cellneoplastic progressionnovelontogenypancreatic malignancypathwaypatients with breast cancerperson with breast cancerplastic surgerypolyoma middle tumor antigenpulmonary metastasisresectionsurgerytranslational opportunitiestranslational potentialtransplanttriple-negative breast cancertriple-negative invasive breast carcinomatumortumor cell metastasistumor growthtumor progressionwhite adipose tissuexeno-transplantxeno-transplantationyellow adipose tissue♀
Description preview
PROJECT SUMMARY
Increased glucose and fat metabolism are essential for tumor progression. Recent work showed that cold-
induced activation of brown adipose tissue (BAT), a unique adipose tissue which produces heat via glycolysis
and fat metabolism, suppressed tumor progression in several cancer mouse models due to competition for
glucose and fat…
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