grant
Biochemical and structural mechanisms at the filoviral-host interface
Organization WASHINGTON UNIVERSITYLocation SAINT LOUIS, UNITED STATESPosted 7 Jul 2016Deadline 31 May 2028
NIHUS FederalResearch GrantFY2025ActinsAddressAfricaAnti-viral AgentsBiochemicalBiochemistryBiological ChemistryBiologyCOVID crisisCOVID epidemicCOVID pandemicCOVID-19 crisisCOVID-19 epidemicCOVID-19 eraCOVID-19 global health crisisCOVID-19 global pandemicCOVID-19 health crisisCOVID-19 pandemicCOVID-19 periodCOVID-19 public health crisisCOVID-19 yearsCRISPRCRISPR/Cas systemCell BodyCell Communication and SignalingCell SignalingCellsCellular MatrixClustered Regularly Interspaced Short Palindromic RepeatsCommunicable DiseasesComplexCore ProteinCryo-electron MicroscopyCryo-electron tomographyCryoelectron MicroscopyCytoskeletal SystemCytoskeletonDataDevelopmentDiseaseDisease OutbreaksDisorderEBOVEC 2.7.7.48Ebola virusEbola-like VirusesElectron CryomicroscopyEventFamilyFiloviridaeFilovirusFrankfurt-Marburg Syndrome VirusGene TranscriptionGenetic TranscriptionGenomeHealthHost FactorHost Factor ProteinHumanHybridsImmuneImmune responseImmunesInfectionInfectious DiseasesInfectious DisorderIntegration Host FactorsIntracellular Communication and SignalingInvestigatorsKnowledgeLDLLDL LipoproteinsLengthLow-Density LipoproteinsMarburgMarburg virusMarburg-like VirusesMarburgvirusMass Photometry/Spectrum AnalysisMass SpectrometryMass SpectroscopyMass SpectrumMass Spectrum AnalysesMass Spectrum AnalysisMethodsModern ManMolecularNatureNon-Polyadenylated RNANucleocapsidNucleocapsid ProteinsNucleoproteinsORFsOpen Reading FramesOrthoebolavirusOrthomarburgvirusOutbreaksPathway interactionsPhysical condensationPlayPolymerasePositionPositioning AttributePost-Translational Modification Protein/Amino Acid BiochemistryPost-Translational ModificationsPost-Translational Protein ModificationPost-Translational Protein ProcessingPosttranslational ModificationsPosttranslational Protein ProcessingProcessProductivityProtein Coding RegionProtein Interaction MapProtein ModificationProtein-Protein Interaction MapProteinsProteomicsPublicationsPublishingR-Series Research ProjectsR01 MechanismR01 ProgramRNARNA ExpressionRNA Gene ProductsRNA ReplicaseRNA chemical synthesisRNA synthesisRNA-Dependent RNA PolymeraseRNA-Directed RNA PolymeraseReceptor ProteinRegulationResearch GrantsResearch PersonnelResearch Project GrantsResearch ProjectsResearch ResourcesResearchersResolutionResourcesRibonucleic AcidRoentgen RaysRoleSARS-CoV-2 epidemicSARS-CoV-2 global health crisisSARS-CoV-2 global pandemicSARS-CoV-2 pandemicSARS-coronavirus-2 epidemicSARS-coronavirus-2 pandemicScientific PublicationSevere Acute Respiratory Syndrome CoV 2 epidemicSevere Acute Respiratory Syndrome CoV 2 pandemicSevere acute respiratory syndrome coronavirus 2 epidemicSevere acute respiratory syndrome coronavirus 2 pandemicShort interfering RNASignal TransductionSignal Transduction SystemsSignalingSingle Crystal DiffractionSmall Interfering RNAStructureTherapeuticTimeTranscriptionViralViral DiseasesViral Gene ProductsViral Gene ProteinsViral ProteinsVirusVirus DiseasesVirus ReplicationWorkX Ray CrystallographiesX-RadiationX-Ray CrystallographyX-Ray Diffraction CrystallographyX-Ray RadiationX-Ray/Neutron CrystallographyX-rayXrayXray Crystallographyanti-viral compoundanti-viral drugsanti-viral medicationanti-viral therapeuticanti-viralsbeta-Lipoproteinsbiological signal transductioncondensationcoronavirus disease 2019 crisiscoronavirus disease 2019 epidemiccoronavirus disease 2019 global health crisiscoronavirus disease 2019 global pandemiccoronavirus disease 2019 health crisiscoronavirus disease 2019 pandemiccoronavirus disease 2019 public health crisiscoronavirus disease crisiscoronavirus disease epidemiccoronavirus disease pandemiccoronavirus disease-19 global pandemiccoronavirus disease-19 pandemiccryo-EMcryo-EM tomographycryoEMcryoEM tomographycryoelectron tomographycryogenic electron microscopydevelopmentalelectron cryo-tomographyenzyme activityglobal healthhost responseimmune system responseimmunoresponseinnovateinnovationinnovativeinsightintracellular skeletonmultidisciplinarymultiomicsmultiple omicsnovelnucleasepanomicsparticlepathwayprotein protein interactionreceptorresolutionssevere acute respiratory syndrome coronavirus 2 global health crisissevere acute respiratory syndrome coronavirus 2 global pandemicsiRNAsocial rolestructural biologytherapeutic targettoolvaccine candidateviral RNAviral infectionviral multiplicationviral replicationvirus RNAvirus infectionvirus multiplicationvirus proteinvirus-induced disease
Description preview
RP01 Project Summary/Abstract for Biochemical and structural mechanisms at the filoviral-host
interface
The recent filoviral outbreaks, including the 2013-2016 Ebola virus (EBOV) outbreak in West Africa that
introduced the virus to other continents, highlight the imminent threat to global health posed by filoviruses and
the urgent need for basic…
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