grant
Benchmarking and Computational framework for Optimal Visualization and Interpretability of high-dimensional Spatiotemporal Data
Organization NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCESLocation UNITED STATES
NIHUS FederalResearch GrantFY2025AddressAdoptedAdventitial CellAlgorithmsBasal PlateBayesian ModelingBayesian adaptive designsBayesian adaptive modelsBayesian belief networkBayesian belief updating modelBayesian frameworkBayesian hierarchical modelBayesian network modelBayesian nonparametric modelsBayesian spatial data modelBayesian spatial image modelsBayesian spatial modelsBayesian statistical modelsBayesian tracking algorithmsBenchmarkingBest Practice AnalysisBioinformaticsBiologicalBiological FunctionBiological ProcessBiomedical ResearchBloodBlood Reticuloendothelial SystemBody TissuesCCL2CCL2 geneCXCL12CXCL12 geneCXCL12 proteinCell BodyCell CommunicationCell InteractionCell-to-Cell InteractionCellsCells Placenta-TissueChemokine (C-X-C Motif) Ligand 12Chemokine, CC Motif, Ligand 2Chemotactic CytokinesChorionic villiCommunicationComplexComputational toolkitDataData SetDeciduaDecidua GraviditasDecidual CellDendritic CellsDependenceDevelopmentDevelopmental ProcessDimensionsDiseaseDisorderEndothelial CellsEndotheliumEpithelial CellsEpitheliumFibroblastsFutureGestationHeterogeneityHomologous Chemotactic CytokinesImmuneImmunesIndividualIntercrinesJobsLeadMCAFMCP-1MCP1MacrophageMeasuresMembraneMesenchymalMethodsMonocyte Chemoattractant Protein-1Monocyte Chemotactic Protein-1Monocyte Chemotactic and Activating FactorMonocyte Chemotactic and Activating ProteinMonocyte Chemotactive and Activating FactorMonocyte Secretory Protein JEMφNK T cellNKT cellNatural Killer T cellNatureNeighborhoodsNerve CellsNerve UnitNeural CellNeurocyteNeuronsNormal PlacentomaOccupationsOrganOutputPBSFPb elementPerformancePericapillary CellPericytesPerivascular CellPlacentaPlacenta Embryonic TissuePlacental DevelopmentPlacental VilliPlacentationPlacentomePre-B Cell Growth Stimulating FactorPregnancyProcessProfessional PositionsPublicationsPublishingRegulatory T-LymphocyteResolutionRoleRouget CellsSCYA2SCYB12SDF-1SDF-1ASDF-1BSDF-1alphaSDF1SDF1ASDF1BSIS cytokinesSamplingScientific PublicationSdf1 proteinSmall Inducible Cytokine A2SpermatogenesisStromal Cell-Derived Factor 1Stromal CellsStructureSyncytiotrophoblastT-CellsT-LymphocyteTLSF-ATLSF-BTPAR1TechniquesTimeTissuesTranslatingTregVeiled CellsVillousVisualVisualizationautoencoderautoencoding neural networkbenchmarkbiologicchemoattractant cytokinechemokinecomplex datacomputational frameworkcomputational toolboxcomputational toolscomputational toolsetcomputer frameworkcomputerized toolsdata complexitydata diversitydata integrationdata reductiondeep learning based modeldeep learning modeldesigndesigningdevelopmentaldimension reductiondimensionality reductiondiverse dataexperimentexperimental researchexperimental studyexperimentsflexibilityflexiblegradient boostinghIRHheavy metal Pbheavy metal leadhigh dimensional datahigh dimensionalityiPSiPSCiPSCsimprovedindexinginduced pluripotent cellinduced pluripotent stem cellinducible pluripotent cellinducible pluripotent stem cellinnovateinnovationinnovativeinsightinterestmembrane structuremultidimensional datamultidimensional datasetsnatural killer T lymphocyteneural networkneuronalnovelpluripotencypluripotent statepreservationreduce data dimensionreduce dimensionalityregulatory T-cellsresolutionssingle cell analysissocial rolespatial and temporalspatial temporalspatiotemporalstromal cell-derived factor-1alphathymus derived lymphocytetooltrophoblasttrustworthiness
Description preview
Single-cell analysis have revolutionized biomedical research, enabling unprecedented insights into cellular heterogeneity, differentiation trajectories, and the mechanisms underlying complex diseases. Despite these advances, the interpretation and visualization of single-cell data remain challenging due to the high dimensionality and complexity of…
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