grant
BCCMA: VA Colorectal Cancer Clinical & Computational Collaborative (VA-5C): NIR-labeled antibodies to target and label colon polyps and cancer for improved diagnosis and surgery
Organization VA SAN DIEGO HEALTHCARE SYSTEMLocation SAN DIEGO, UNITED STATESPosted 1 Oct 2024Deadline 30 Sept 2028
VANIHUS FederalResearch GrantFY2025AI analysisAI systemAbscissionAccuracy of DiagnosisAchievementAchievement AttainmentAirAntibodiesApplications GrantsArtificial IntelligenceAwardBackBehaviorBiologicalBloodBlood Reticuloendothelial SystemBody TissuesBostonCRC screeningCancer CauseCancer EtiologyCancersCause of DeathCessation of lifeClassificationClinicalClinical TrialsColonColon CancerColon CarcinomaColon NeoplasmsColon TumorColonic MassColonic NeoplasmsColonic PolypsColonic TumorColonoscopesColonoscopyColorectal CancerColorectal NeoplasmsColorectal TumorsColoring AgentsComputer ReasoningComputer aided diagnosisComputer-Assisted DiagnosisCoon's TechnicCoon's TechniqueDNA mutationDataDeathDepositDepositionDetectionDevelopmentDiagnosisDiseaseDisorderDistantDorsumDyesEarly DiagnosisEndoscopyEnvironmentEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessExcisionExtirpationFeasibility StudiesFluorescenceFluorescent Antibody TechnicFluorescent Antibody TechniqueFluorescent Antinuclear Antibody TestFundingGEM modelGEMM modelGenetic ChangeGenetic defectGenetic mutationGenetically Engineered MouseGenomeGoalsGrant ProposalsHepatic Neoplasm SecondaryHepatic metastasisHeterograftHeterologous TransplantationHomeImageImmunofluorescenceImmunofluorescence ImmunologicImmunofluorescence TechnicImmunofluorescence TechniqueImmunohistochemistryImmunohistochemistry Cell/TissueImmunohistochemistry Staining MethodIndividualInterdisciplinary ResearchInterdisciplinary StudyInterventionLabelLarge Bowel TumorLarge Intestine NeoplasmLarge Intestine TumorLibrariesLightLinkLiver secondariesLiver secondary cancerLos AngelesMachine IntelligenceMalignantMalignant - descriptorMalignant NeoplasmsMalignant TumorMetastasisMetastasizeMetastatic LesionMetastatic MassMetastatic NeoplasmMetastatic Neoplasm to the LiverMetastatic TumorMetastatic Tumor to the LiverMetastatic malignant neoplasm to liverMethodsMiceMice MammalsModelingMucinsMucus GlycoproteinMultidisciplinary CollaborationMultidisciplinary ResearchMurineMusMutationNIR dyeNIR imagingNIR optical imagingNear-infrared Fluorescence ImagingNear-infrared optical imagingNeoplasm MetastasisOperative ProceduresOperative Surgical ProceduresOutcomePatient outcomePatient-Centered OutcomesPatient-Focused OutcomesPatientsPenetrationPerformancePhotoradiationPolypsPrognosisPropertyPublishingRemovalResearchRiskRoleScienceSecondary NeoplasmSecondary TumorSerrated AdenomaSolid NeoplasmSolid TumorSpecificityStaining methodStainsSurgicalSurgical InterventionsSurgical ProcedureSurgical RemovalSystemSystematicsTestingTimeTissuesToxic effectToxicitiesTransmissionTreatment outcomeTumor AntigensTumor TissueTumor-Associated AntigenVHHVHH antibodyVeteransVisualVisualizationXenograftXenograft ModelXenograft procedureXenotransplantationanalysis with AIanalysis with artificial intelligenceanalyze microbiomeanalyzed via AIanalyzed via artificial intelligenceantibody conjugateartificial intelligence analysisbiologiccamelid antibodycamelid based antibodycamelid derived antibodycamelid derived fragmentcamelid heavy chain only Abscamelid immunoglobulincamelid single chain antibodycamelid variable heavy chaincancer antigenscancer in the coloncancer metastasiscancer surgeryclinical developmentclinical validationcohortcolon cancer riskcolon neoplasiacolon polypcolorectal cancer detectioncolorectal cancer early detectioncolorectal cancer metastasiscolorectal cancer screeningcolorectal neoplasiacompare to controlcomparison controldetect colorectal cancerdevelopmentaldiagnostic accuracyearly detectioneffective therapyeffective treatmentendoscopic imagingepigeneticallyexperimentexperimental researchexperimental studyexperimentsfluorescence imagingfluorescence-guided surgeryfluorescent antibodyfluorescent imagingfluorophoregenetically engineered mouse modelgenetically engineered murine modelgenome mutationglobal gene expressionglobal transcription profilehigh riskhomesimagingimaging systemimprovedimproved outcomein vivointerestlarge bowel neoplasmliver metastasesmalignancymalignant liver neoplasm, specified as secondarymetabolomemetabonomemetastasis in the livermetastasis to the livermetastasize to the livermetastatic cancer to livermetastatic colo-rectalmetastatic colo-rectal cancermetastatic colo-rectal carcinomametastatic colon cancermetastatic colorectalmetastatic colorectal cancermetastatic colorectal carcinomametastatic livermetastatic liver neoplasmmicrobiomemicrobiome analysismilitary veteranmolecular imagingmolecule imagingmouse modelmultiomicsmultiple omicsmurine modelnanobodiesnanobodynear IR dyenear infrared dyenear infrared imagingneoplasm/cancerneoplasticnovelpanomicspatient oriented outcomesprecancerprecancerouspremalignantresectionsdAbsecondary liver malignancysecondary malignant liver neoplasmsingle domain antibodiessocial rolestemsuccesssurgerysurgery outcomesurgical outcometranscriptometransmission processtumortumor cell metastasistumor-specific antigenvariable heavy chain antibodyveteran populationxeno-transplantxeno-transplantationxenograft transplant modelxenotransplant model
Description preview
Colorectal cancers comprise the third most common cause of cancer-related death in the US and are major
causes of death in the Veteran population. For colorectal cancer, early detection and complete surgical resection
of tumors are critical to patient outcomes. The present application aims to develop a tumor-targeting fluorescent
antibody that…
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