grant
BCCMA: Recovery of Aged Muscle After Disuse Atrophy (REMEDY): Targeting metabolism to accelerate recovery from disuse atrophy in aged mice
Organization WM S. MIDDLETON MEMORIAL VETERANS HOSPLocation MADISON, UNITED STATESPosted 1 Jan 2026Deadline 31 Dec 2029
VANIHUS FederalResearch GrantFY2026ACRP30 proteinAccelerationAddressAdipose tissueAgeAgingAgonistAnti-InflammatoriesAnti-Inflammatory AgentsAnti-inflammatoryAtrophicAtrophyBed restBedrestBiologicalBiologyBody TissuesCausalityCell Communication and SignalingCell SignalingClinicalCollaborationsDataData SetDietDisuse AtrophyElderlyEtiologyExerciseExtremitiesFatty TissueFemaleFiberFibrosisGeneral PopulationGeneral PublicGeneralized GrowthGoalsGrowthHealthHindlimb ElevationHindlimb ImmobilizationHindlimb SuspensionHindlimb UnloadingHistologicHistologicallyHospital AdmissionHospitalizationHospitalsHybridsImpairmentInflammationInflammatoryInjuryInpatientsIntermediary MetabolismIntracellular Communication and SignalingIntramuscularKineticsLifeLimb structureLimbsLinkLipidsMeasuresMedical RehabilitationMetabolicMetabolic ProcessesMetabolismMethodsMiceMice MammalsMitochondriaModelingMolecularMonitorMorbidityMurineMusMuscleMuscle AtrophyMuscle MitochondriaMuscle TissueMuscle WeaknessMuscle functionMuscular AtrophyMuscular WeaknessNon-TrunkObesityOperative ProceduresOperative Surgical ProceduresPathologicPathologyPathway interactionsPeptidesPerformancePhasePhenotypePhysical FunctionPhysical PerformancePre-Clinical ModelPreclinical ModelsPremature MortalityProcessProteomicsReceptor ProteinRecoveryRehabilitationRehabilitation therapyRejuvenationRiskSarcosomesSignal TransductionSignal Transduction SystemsSignalingSiteSkeletal MuscleSurgicalSurgical InterventionsSurgical ProcedureSuspension substanceSuspensionsTestingTherapeuticTissue GrowthTissuesTranslatingVeteransVoluntary MuscleWorkaccelerated agingaccelerated biological ageaccelerated biological agingadipocyte complement-related protein 30-kDaadipocyte, C1q and collagen domain containing proteinadipocytokinesadipokinesadiponectinadiposeadiposityadvanced ageage accelerationage associatedage associated alterationsage associated changesage associated diseaseage associated disorderage associated impairmentage correlatedage correlated alterationsage correlated changesage dependentage dependent alterationsage dependent changesage dependent diseaseage dependent disorderage dependent impairmentage induced alterationsage induced changesage linkedage relatedage related alterationsage related changesage related human diseaseage specificage specific alterationsage specific changesage-related diseaseage-related disorderage-related impairmentaged miceaged mouseaged muscleagesaging associated alterationsaging associated changesaging correlated alterationsaging correlated changesaging dependent alterationsaging dependent changesaging induced alterationsaging induced changesaging of muscleaging related alterationsaging related changesaging specific alterationsaging specific changesalterations with ageapM-1 proteinapM1 (adipose-specific) proteinassess effectivenessbiologicbiological signal transductioncausationchanges with ageclinical implementationclinical relevanceclinically relevantcorpulencecritical perioddesigndesigningdetermine effectivenessdietsdisabilitydisease causationeffectiveness assessmenteffectiveness evaluationelderly miceevaluate effectivenessexamine effectivenessexperimentexperimental researchexperimental studyexperimentsfat metabolismfrailtyfunctional lossgeriatrichigh riskin vivoindexinginjuriesinnovateinnovationinnovativeinsightlipid metabolismlipidomicsmalemetabolism measurementmetabolomicsmetabonomicsmid lifemid-lifemiddle agemiddle agedmidlifemilitary veteranmitochondrialmitochondrial metabolismmultimorbiditymultiple chronic conditionsmuscle agingmuscle breakdownmuscle bulkmuscle degradationmuscle deteriorationmuscle formmuscle lossmuscle massmuscle metabolismmuscle wastingmuscularnew approachesnovelnovel approachesnovel strategiesnovel strategyold miceolder adultolder adulthoodontogenypathwaypharmacologicpre-clinical studyprecision medicineprecision-based medicinepreclinical studyprotein homeostasisproteostasisreceptorrehab therapyrehabilitativerehabilitative therapyresilienceresilientresponserestorationsenior citizensex dimorphismsexual dimorphismsexually dimorphicskeletal muscle metabolismskeletal muscle protein metabolismsuccesssurgerysynergismtherapeutic agent developmenttherapeutic developmenttooltranscriptomicsveteran populationwhite adipose tissueyellow adipose tissue♀♂
Description preview
Older Veterans have a greater burden of multi-morbidity compared to the general population, resulting in frequent
and re-occurring inpatient hospitalizations. The inability to recover from hospital acquired muscle weakness is
linked to hospital readmittance, morbidity, and pre-mature mortality after discharge. Unfortunately, there are no
effective…
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