grant
BCCMA: Recovery of Aged Muscle After Disuse Atrophy (REMEDY): Targeting energetics and proteostasis in recovery from disuse atrophy
Organization OKLAHOMA CITY VA MEDICAL CENTERLocation OKLAHOMA CITY, UNITED STATESPosted 1 Apr 2025Deadline 31 Mar 2029
VANIHUS FederalResearch GrantFY202521+ years oldAccelerationAddressAdultAdult HumanAerobicAgeAgingAtrophicAtrophyAutoregulationBed restBedrestBioenergeticsBiologicalBreedingCausalityClinicalClinical TreatmentClinical TrialsCommon Rat StrainsDisuse AtrophyDisuse-Induced Bone LossDown-RegulationER stressEarly InterventionEtiologyExerciseFutureGeneralized GrowthGenesGrowthHindlimbHindlimb ElevationHindlimb ImmobilizationHindlimb SuspensionHindlimb UnloadingHomeostasisHospital AdmissionHospitalizationHospitalsHumanImpairmentInflammationInpatientsIntermediary MetabolismLoad BearingMaintenanceMetabolic ProcessesMetabolismMethodsMitochondriaModelingModern ManMonitorMorbidityMorbidity - disease rateMuscleMuscle AtrophyMuscle ProteinsMuscle TissueMuscle functionMuscular AtrophyPhenotypePhysical FunctionPhysiological HomeostasisPopulationPre-Clinical ModelPreclinical ModelsProcessProtein BiosynthesisProteinsProteomicsProtocolProtocols documentationQuality ControlRatRats MammalsRattusRecoveryRecovery of FunctionRibosomal Peptide BiosynthesisRibosomal Protein BiosynthesisRibosomal Protein SynthesisRiskRodentRodentiaRodents MammalsSkeletal MuscleTail SuspensionTestingTherapeuticTissue GrowthTracerTrainingVO2 maxVO2maxVeteransVoluntary MuscleWeight BearingWeight-Bearing stateadult youthadulthoodadvanced age ratsagedaged animalaged animalsaged muscleaged rataged ratsagesaging of muscleanimal old agebiologicbone disuse atrophycausationclinical implementationclinical interventionclinical therapycostdisabilitydisease causationdisuse - associated bone lossdisuse - induced atrophydisuse osteoporosiselderly animalelderly ratsendoplasmic reticulum stressendurance exerciseexercise trainingexperimentexperimental researchexperimental studyexperimentsfrailtyfunctional outcomesfunctional recoverygeriatric ratshigh riskimprovedinnovateinnovationinnovativeinsoluble aggregatemaximal oxygen uptakemilitary veteranmitochondrialmuscle agingmuscle breakdownmuscle bulkmuscle degradationmuscle deteriorationmuscle formmuscle lossmuscle massmuscle wastingmuscularold animalsold ratsontogenyprecision medicineprecision-based medicineprotein aggregateprotein aggregationprotein homeostasisprotein synthesisproteostasisresilienceresilientrespiratoryresponsestemtherapeutic targettraittreadmill trainingtrial regimentrial treatmentveteran populationyoung adultyoung adult ageyoung adulthood
Description preview
The aging Veteran population has more frequent inpatient hospitalizations than non-Veteran populations. In
older Veterans there is an inability to fully recover muscle mass and function after hospital-acquired weakness.
The consequence of repeated periods of disuse is a hastening of the progression to disability or frailty for older
Veterans. We…
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