grant
BCCMA: Determinants and early detection of metastasis in melanoma for unmet needs of Veterans with mucosal melanomas affecting the head, neck, and other rare types
Organization VA NEW JERSEY HEALTH CARE SYSTEMLocation EAST ORANGE, UNITED STATESPosted 1 Oct 2024Deadline 30 Sept 2028
VANIHUS FederalResearch GrantFY2025Acral Lentiginous Malignant MelanomaAcral Lentiginous MelanomaAffectAreaAwardB-raf-1BRAFBRAF geneC-KIT GeneCD117CD117 AntigensCancer GenesCancer-Promoting GeneCausalityCell Communication and SignalingCell DifferentiationCell Differentiation processCell SignalingCellular ExpansionCellular GrowthCharacteristicsClinicalClinical TrialsCritical PathsCritical PathwaysDataDevelopmentDiagnosisDiseaseDisorderDorsalEarly DiagnosisEtiologyEventExperimental ModelsExperimental TherapiesExtracellular Signal-Regulated Kinase GeneGPRC1AGRM1GRM1 geneGRM1AGeneralized GrowthGeneticGenotypeGrowthHeadHumanImmune mediated therapyImmunologically Directed TherapyImmunotherapyIn VitroIndividualIntracellular Communication and SignalingInvestigational TherapiesInvestigational TreatmentsInvestigatorsKnowledgeLesionLocationMAP Kinase GeneMAPKMGLUR1MGLUR1AMaintenanceMalignant MelanomaMast Cell Growth Factor ReceptorMediatingMelanomaMelanoma CellMelanoma MetastasisMelanoma TumorMelanoma patientMetabotropic 1 Glutamate ReceptorMetastasisMetastasizeMetastatic LesionMetastatic MassMetastatic MelanomaMetastatic NeoplasmMetastatic TumorMiceMice MammalsMitogen-Activated Protein Kinase GeneModalityModern ManMolecularMucosaMucosal TissueMucous MembraneMurineMusMutateNatureNeckNeoplasm Circulating CellsNeoplasm MetastasisNerve CellsNerve UnitNeural CellNeurocyteNeuronsNon-Polyadenylated RNAOncogenesPDX modelPI-3K/AKTPI3K/AKTPathogenesisPatient derived xenograftPatientsPhenotypePositionPositioning AttributePrimary NeoplasmPrimary TumorPrognosisProteinsProto-Oncogene Protein c-kitRAFB1RNARNA Gene ProductsRNA SeqRNA sequencingRNAseqReceptor ProteinResearchResearch PersonnelResearch SpecimenResearchersRibonucleic AcidRoleSCF ReceptorSCF Receptor GeneSCFRSamplingSeasonsSecondary NeoplasmSecondary TumorSignal PathwaySignal TransductionSignal Transduction SystemsSignalingSkinSpecimenStem Cell Factor ReceptorStem Cell Factor Receptor GeneTestingTherapeuticTimeTissue ArraysTissue ChipTissue GrowthTissue MicroarrayTransforming GenesTransgenic MiceTumor growth in melanomaValidationVeteransWorkacral melanomaadvanced diseaseadvanced illnessbiological signal transductionc kitc-kit Proteinc-kit Receptorcancer metastasiscancer progressioncancers that are rarecareercausationcell growthcellular differentiationcirculating neoplastic cellcirculating tumor celldevelopmentaldisease causationdisease modeldisorder modelearly detectioneffective therapyeffective treatmentexperimental therapeutic agentsexperimental therapeuticsgene manipulationgenetic analysisgenetic manipulationgenetically manipulategenetically perturbglutamate signalingglutamatergic dendrodendritic synapsesglutamatergic signalinghistologic stainshistological stainsimmune therapeutic approachimmune therapeutic interventionsimmune therapeutic regimensimmune therapeutic strategyimmune therapyimmune-based therapiesimmune-based treatmentsimmuno therapyimprovedin vivoinhibitorinnovateinnovationinnovativeintervention designkit Proto-Oncogene ProteinmGlu1melanocytemelanocyte progenitormelanocyte stem cellsmelanoma cancer modelmelanoma modelmelanoma tumor modelmetabotropic glutamate receptor type 1mouse modelmucosal melanomamultidisciplinarymurine modelneoplasm progressionneoplastic progressionneuronalontogenyp145(c-kit)p145c-kitpatient derived xenograft modelpatients suffering from melanomapatients with melanomapharmacologicpre-clinicalpreclinicalprogenitor biologyprogenitor cell biologyprogenitor cell markersprogenitor markersprogenitor stem cell markersrare cancerrare malignancyrare tumorrational designreceptorresistance to therapyresistant to therapysenescencesenescentsocial rolestem and progenitor biologystem cell biologystem cell biomarkersstem cell markerstargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttherapeutic resistancetherapy designtherapy resistanttooltranscriptome sequencingtranscriptomic sequencingtranscriptomicstreatment designtreatment resistancetumortumor cell metastasistumor progressionv-raf Murine Sarcoma Viral Oncogene Homolog B1validations
Description preview
Overall Research Strategy: Advancements in melanoma research and treatment over the past twenty years
have not significantly benefitted Veterans and other patients with rarer melanoma types. These include mucosal
melanomas (MM), which affect the head, neck, and anogenital skin; and acral melanomas (AM), occurring on
the palms and the soles, which…
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