grant
BCCMA: Cognitive phenotypes of emotion regulation and suicide risk in Veterans with TBI: Mechanistic Neurobehavioral Model of Emotional Reactivity
Organization VA NEW JERSEY HEALTH CARE SYSTEMLocation EAST ORANGE, UNITED STATESPosted 1 Apr 2026Deadline 31 Mar 2030
VANIHUS FederalResearch GrantFY2026AcousticsAddressAffectAgonistAnimal ModelAnimal Models and Related StudiesAnimalsAreaArousalAutomobile DrivingAutonomic nervous systemAwardBacteriaBody SystemBrainBrain InflammationBrain Nervous SystemBrain StemBrain TraumaBrainstemCell BodyCell Communication and SignalingCell NucleusCell SignalingCellsChronicClinicalCognitiveCollaborationsCollectionCommon Rat StrainsCranial Nerve XDataDifferences between sexesDiffers between sexesDrugsDuraDura MaterECGEKGElectrocardiogramElectrocardiographyEmotionalEncephalitisEncephalonEnvironmentEquilibriumEvaluationEventExhibitsFaceFearFemaleFore-BrainForebrainFoundationsFrightFutureGI microbiomeGene TranscriptionGenetic TranscriptionGoalsHarvestHcrt proteinHcrt/ORXHcrts/ORXsHealthHeartHistoryHumanInflammationInfusionInfusion proceduresInjuryInterventionIntracellular Communication and SignalingKnowledgeLateralLearningLevarterenolLevonorepinephrineLiquid substanceLocus CoeruleusLong-Term EffectsMeasuresMedicationMicroinjectionsModelingModern ManMorphologyNerve CellsNerve Impulse TransmissionNerve TransmissionNerve UnitNeural CellNeurocyteNeuronal TransmissionNeuronsNoradrenalineNorepinephrineNucleusNucleus Pigmentosus PontisOdorsOrgan SystemParasympathetic Nervous SystemPathway interactionsPatientsPercussionPeripheralPharmaceutical PreparationsPhenotypePhysiologicPhysiologicalPhysiologyPneumogastric NerveProcessProsencephalonR-Series Research ProjectsR01 MechanismR01 ProgramRNA ExpressionRNA analysisRatRats MammalsRattusReactionReceptor ProteinRecording of previous eventsReportingResearch GrantsResearch Project GrantsResearch ProjectsRisk FactorsRisk ReductionRouteSensorySex DifferencesSexual differencesSignal TransductionSignal Transduction SystemsSignalingSiteSpinal ColumnSpineSprague-Dawley RatsStartle ReactionStimulusSuicideSuicide attemptSympathetic Nervous SystemTenth Cranial NerveTestingTimeTranscriptionTraumatic Brain InjuryVagus NerveVagus nerve structureVertebral columnVeteransWomanaxon signalingaxon-glial signalingaxonal signalingbackbonebacteria in the gutbalancebalance functionbeta-adrenergic receptorbiological signal transductionblue nucleuscell typecognitive controldensitydesigndesigningdigestive tract microbiomedrivingdrug/agentemotion dysregulationemotion regulationemotional dysregulationemotional reactionemotional regulationenteric microbiomeexperimentexperimental researchexperimental studyexperimentsfacesfacialfatal attemptfatal suicidefecal samplefluidfluid percussion injurygastrointestinal microbiomeglia signalingglial signalinggut bacteriagut dysbiosisgut microbiomegut to brain axisgut-associated microbiomegut-brain axisgut-brain communicationgut-brain interactionsgut-brain relationshipgut-brain signalingheart rate variabilityhistorieshypocretinhypocretin/orexinhypocretins/orexinsinfusionsinjuriesintent to dieintestinal biomeintestinal microbiomeliquidlocus ceruleus structuremalemodel of animalnerve signalingneural inflammationneural signalingneurobehavioralneuroinflammationneuroinflammatoryneuronalneuronal signalingneurotransmissionnon fatal attemptnonfatal attemptnoradrenergicorexinpathwaypharmacologicreceptorreduce riskreduce risksreduce that riskreduce the riskreduce these risksreduces riskreduces the riskreducing riskreducing the riskresponserisk-reducingsexsex based differencessex-dependent differencessex-related differencessex-specific differencesstartle responsestool samplestool specimensuicidal attemptsuicidal behaviorsuicidal risksuicide behaviorsuicide risksuicidestraumatic brain damageβ-adrenergic receptor♀♂
Description preview
This VA Merit proposal is part of a BLR&D/CSR&D Collaborative Merit Award for traumatic brain injury (TBI;
BCCMA) proposal (RFP #BX-24-007) involving four separate but integrated proposals that together
investigate the overarching model that TBI impacts cognitive phenotypes and emotion dysregulation via
multiple pathways, which in turn increase…
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