grant
Bacteriophage virus-like particle vaccines for fentanyl and heroin overdose
Organization UNIVERSITY OF NEW MEXICO HEALTH SCIS CTRLocation ALBUQUERQUE, UNITED STATESPosted 30 Sept 2021Deadline 30 Nov 2028
NIHUS FederalResearch GrantFY20256-O-monoacetylmorphine6-acetylmorphine6-monoacetylmorphineActiqAdanonAddressAdjuvantAffinityAlthoseAnimal ModelAnimal Models and Related StudiesAntibodiesAntibody AffinityAntibody titer measurementBBB crossingBacteriophagesBindingBloodBlood Reticuloendothelial SystemBlood SerumBuprenorphineCNS Nervous SystemCentral Nervous SystemChemicalsClinicalCollaborationsCombination VaccinesCombined VaccinesCommon Rat StrainsContracting OpportunitiesContractsDataDevelopmentDevelopment PlansDiacetylmorphineDiamorphineDihydrohydroxycodeinoneDolophineDomestic RabbitDoseDrugsDuragesicEngineeringFentanestFentanylFentylFundingGeneral PopulationGeneral PublicGenerationsGuidelinesHeroinHumanImmunizationInfumorphIngestionInhalationInhalingInjectionsInternationalIntramuscularIntravenousKadianKineticsLaboratoriesLeadLengthLength of LifeLifeLongevityMS ContinMSirMedicationMedicinal ChemistryMethadoneMethadoseMiceMice MammalsModelingModern ManModificationMolecular InteractionMonitorMorphiaMorphineMurineMusNHP modelsNaloxoneNarcanNarcantiNational Institutes of HealthNeuraxisNew MexicoOpiatesOpioidOral AdministrationOral Drug AdministrationOramorphOramorph SROryctolagus cuniculusOverdoseOxycodeinonOxycodoneOxycodone SROxycontinPatientsPb elementPeptide-based drugPersonsPhagesPharmaceutic ChemistryPharmaceutical AgentPharmaceutical ChemistryPharmaceutical PreparationsPharmaceuticalsPharmaciesPharmacologic SubstancePharmacological SubstancePharmacologyPharmacy facilityPhasePhentanylPreparationProcessProductionProtocolProtocols documentationRabbitsRabbits MammalsRatRats MammalsRattusRespiratory DepressionRouteRoxanolRoxicodoneSafetySelf AdministeredSelf AdministrationSerumSiteSpecificityStatex SRSurfaceTestingToxic effectToxicitiesToxicologyUnited StatesUnited States National Institutes of HealthUniversitiesVaccinationVaccine AdjuvantVaccinesVentilatory DepressionVirus-like particleabused drugabused drugsantibody titeringantigen antibody affinityantinociceptionantinociceptivebacterial virusblood-brain barrier crossingbloodbrain barrier crossingcell bankcollegecollegiatedensitydepressed breathingdepression of breathingdevelop a vaccinedevelop vaccinesdevelopment of a vaccinedevelopmentaldiamorphine overdosedrug abuseddrug of abusedrug/agentdrugs abuseddrugs of abuseefficacy studyefficacy testingendogenous opiateendogenous opioidsexperiencefentanyl overdoseheavy metal Pbheavy metal leadheroin overdoseimmune response to vaccinationimmune response to vaccinesimmunogenicimmunogenicityindustrial partnershipindustry partnerindustry partnershipingestinterestintraoral drug deliverylead candidatemanufacturemanufacturing runmedical collegemedical schoolsmodel of animalmorphine-6-acetatenew approachesnew vaccinesnext generation vaccinesnonhuman primate modelsnovel approachesnovel strategiesnovel strategynovel vaccinesopiate crisisopiate overdoseopiate related overdoseopiate use disorderopioid crisisopioid drug overdoseopioid epidemicopioid induced overdoseopioid intoxicationopioid medication overdoseopioid overdoseopioid poisoningopioid related overdoseopioid toxicityopioid use disorderoverdose deathoverdose fatalitiespeptide drugpharmaceuticalpre-IND enabling studiespre-IND experimentspre-IND studiespre-clinical developmentpreclinical developmentpreparationspreventpreventingproduct developmentproduction runprogramsresponseschool of medicinetherapeutic peptidevaccine associated immune responsevaccine candidatevaccine developmentvaccine efficacyvaccine formulationvaccine immune responsevaccine immunogenicityvaccine induced immune responsevaccine platformvaccine strategyvirus-like nanoparticlesviruslike particle
Description preview
PROJECT SUMMARY
Opioids account for close to 70% of overdose deaths in the United States, with fentanyl and heroin two of the
most common causes. Treatment of opioid overdose currently relies on rapid administration of naloxone. New
strategies to prevent opioid overdose are desperately needed as a part of a comprehensive approach to
address the…
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