grant
Bacteriophage as a predictive biomarker in chronic Pseudomonas airway disease
Organization CHILDREN'S HOSPITAL OF LOS ANGELESLocation LOS ANGELES, UNITED STATESPosted 22 Aug 2023Deadline 31 Jul 2028
NIHUS FederalResearch GrantFY202521+ years oldAcuteAddressAdultAdult HumanAdvisory CommitteesAirway DiseaseAirway failureAirway infectionsAnti-microbial susceptibilityAntibiotic AgentsAntibiotic DrugsAntibiotic ResistanceAntibiotic TherapyAntibiotic TreatmentAntibioticsAntimicrobial ResistanceAz-threonamAzactamAzthreonamAztreonamBacterial ChromosomesBacteriophagesBiological MarkersBiological TestingBiologyBiometricsBiometryBiostatisticsBronchiectasisCF airwayCF infectionCF lung diseaseCF patientsCF sputumCaringChronicChrysemonasClinicalClinical ResearchClinical StudyClinical TrialsClinical Trials DesignCystic FibrosisCystic Fibrosis sputumDataDenmarkDevelopmentDevelopment PlansDiseaseDisease ManagementDisorderDisorder ManagementEnvironmentEvolutionFilamentous BacteriophagesFlavimonasFoundationsFutureGeneralized GrowthGenomicsGlycansGrowthHumanImpairmentIn VitroInfectionInhalationInhalingInovirusLong-term cohortLong-term infectionLongitudinal cohortLungLung DiseasesLung Respiratory SystemLung infectionsMeasuresMediatingMentorsMicrobial BiofilmsMicrobiologyMinimum Inhibitory Concentration measurementMinimum Inhibitory ConcentrationsMiscellaneous AntibioticModern ManMucoviscidosisNon-lyticNonlyticOrganismP aeruginosaP. aeruginosaP. aeruginosa infectionPatient CarePatient Care DeliveryPatientsPersonalized medical approachPhagesPhenotypePhylogenyPhysiciansPneumologyPneumonologyPolysaccharidesPopulationProphagesPseudomonasPseudomonas aeruginosaPseudomonas aeruginosa infectionPseudomonas pyocyaneaPublishingPulmonary Cystic FibrosisPulmonary DiseasesPulmonary DisorderPulmonary MedicinePulmonologyRecurrenceRecurrentResearchResistanceResistance to antibioticsResistant to antibioticsRespiratory DiseaseRespiratory FailureRespiratory InfectionsRespiratory System DiseaseRespiratory System DisorderRespiratory Tract InfectionsRetrospective cohortSamplingScientistSerial PassageSputumTask ForcesTestingTherapeuticTimeTissue GrowthTobramycinTobrexTracheostomyTracheostomy procedureTrainingTranslational ResearchTranslational ScienceVirionVirus IntegrationVirus Particleadulthoodadvisory teamanti-microbial resistantantibiotic drug resistanceantibiotic resistance emergenceantibiotic resistantantibiotic tolerancebacterial disease treatmentbacterial infectious disease treatmentbacterial virusbio-markersbiobankbiofilmbiologic markerbiomarkerbiorepositorycare for patientscare of patientscareercareer developmentcaring for patientschronic infectionclinical carecohortcystic fibrosis airwaycystic fibrosis infectioncystic fibrosis lungcystic fibrosis lung diseasecystic fibrosis patientsdevelopmentaldisease of the lungdisorder of the lungemerging antibiotic resistanceentire genomeexperienceexperimentexperimental researchexperimental studyexperimentsfull genomegene functiongenome sequencingimproved outcomein vivoindividualized approachindividuals with CFindividuals with cystic fibrosisinfected with P. aeruginosainfected with Pseudomonas aeruginosainfection in CFinfection in cystic fibrosisinsightliving systemlung disorderlung functionmucoidnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovelnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapyontogenypathogenpatients with CFpatients with cystic fibrosispersistent infectionpersonalized approachprecision approachpredict responsivenesspredicting responsepredictive biological markerpredictive biomarkerspredictive markerpredictive molecular biomarkerprospectivepulmonarypulmonary functionpulmonary infectionsresistance generesistance locusresistance to anti-microbialresistantresistant generesistant to antimicrobialrespiratoryresponseresponse biomarkerresponse markersskillstailored approachtolerance to antibioticstolerate antibioticstranslation researchtranslational investigationtranslational medicinetreatment strategyviral genome integrationviral integrationvirus genome integrationwhole genome
Description preview
PROJECT SUMMARY / ABSTRACT
Despite major advances in therapy, pulmonary disease continues to dominate the clinical course
of patients with cystic fibrosis (CF). All patients with CF develop chronic lung infections, with
Pseudomonas aeruginosa (Pa) becoming a predominant organism in adulthood. Even in the face of
chronic inhalational antibiotic…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click