grant
Bacterial Cholesterol-Dependent Cytolysins in Inflammasome Activation
Organization UNIVERSITY OF CHICAGOLocation CHICAGO, UNITED STATESPosted 24 Jan 2025Deadline 31 Dec 2029
NIHUS FederalResearch GrantFY2025AffectAnthraxAnthrax diseaseB anthracisB. anthracisBacillus anthracisBacteriaBacterial InfectionsBeta Proprotein Interleukin 1BindingC perfringensC perfringens pfoA gene productC perfringens theta-toxinC welchiiC. perfringensC. welchiiCell BodyCell Communication and SignalingCell DeathCell SignalingCell membraneCellsCholesterolClostridium perfringensClostridium perfringens theta-toxinClostridium welchiiCommunicable DiseasesComplexCytolysinsCytoplasmic MembraneDataFoundationsGas GangreneGeneralized GrowthGrowthHost DefenseHost FactorHost Factor ProteinIFN-Gamma-Inducing Factor GeneIFN-gamma-Inducing FactorIGIFIGIF GeneIL-1 GammaIL-1 Gamma GeneIL-1 betaIL-1 βIL-1-bIL-18IL-18 GeneIL-1gIL-1g GeneIL-1βIL1-BetaIL1-βIL18IL18 ProteinIL18 geneIL1B ProteinIL1F2IL1F4IL1F4 GeneIL1βImmune signalingInfectionInfectious DiseasesInfectious DisorderInflammasomeInflammationInflammatoryInflammatory ResponseIntegration Host FactorsInterferon-Gamma-Inducing Factor GeneInterferon-gamma-Inducing FactorInterleukin 18 (Interferon-Gamma-Inducing Factor)Interleukin 18 (Interferon-Gamma-Inducing Factor) GeneInterleukin 18 ProproteinInterleukin 18 Proprotein GeneInterleukin 1betaInterleukin-1 GammaInterleukin-1 Gamma GeneInterleukin-1 betaInterleukin-18Interleukin-18 PrecursorInterleukin-18 Precursor GeneInterleukin-1βIntracellular Communication and SignalingInvadedLifeLigandsListeria monocytogenes hlyA proteinListeria monocytogenes lisA proteinListeriolysinMGC12320MGC12320 GeneMass Photometry/Spectrum AnalysisMass SpectrometryMass SpectroscopyMass SpectrumMass Spectrum AnalysesMass Spectrum AnalysisMediatingMembraneMiceMice MammalsModelingMolecularMolecular InteractionMurineMusOrganellesOrganismPathogenesisPathogenicityPathogenicity FactorsPathway interactionsPatternPerfringolysin OPlasma MembranePreinterleukin 1 BetaProcessProteinsResearch ProposalsRouteS. pyogenesSignal PathwaySignal TransductionSignal Transduction SystemsSignalingStimulusStreptococcus Group AStreptococcus pyogenesStreptolysinsTherapeuticTissue GrowthToxinVirulence FactorsWild Type Mouseanthracisanti-microbialantimicrobialarms racebacteria infectionbacteria pathogenbacterial diseasebacterial pathogenbiological signal transductionbiological weaponbioweaponcytokineextracellularfood-born illnessfood-borne diseasefood-borne illnessfoodborn illnessfoodborne diseasefoodborne illnessgroup A strephuman pathogenimaging systeminnovateinnovationinnovativeinsightlisteriolysin Olive cell imagelive cell imaginglive cellular imagelive cellular imagingliving systemmembrane structuremicrobialmouse modelmurine modelmutantnecrocytosisnew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic targetnew therapy targetnovelnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel therapeutic targetnovel therapy targetontogenypathogenpathogenic bacteriapathwayplasmalemmarational designreconstitutereconstitutionrepairrepairedsmall moleculesubcutaneoussubdermaltherapeutic targettheta hemolysintooltraffickingtrans-Golgi Networktrans-Golgi Regionswildtype mouse
Description preview
PROJECT SUMMARY
Bacterial cholesterol-dependent cytolysins (CDCs) constitute the largest group of pore-forming toxins and
serve as critical virulence factors for a wide variety of pathogenic bacteria. A number of CDCs are known to
activate the NLRP3 inflammasome, a multiprotein innate immune signaling complex responsible for induction
of…
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