grant
Bacterial cell wall remodeling, innate immunity, and pathogenesis
Organization UNIVERSITY OF ILLINOIS AT CHICAGOLocation Chicago, UNITED STATESPosted 7 Jul 2025Deadline 30 Jun 2029
NIHUS FederalResearch GrantFY2025Antibiotic AgentsAntibiotic DrugsAntibiotic TherapyAntibiotic TreatmentAntibioticsAntimicrobial ResistanceApoptosis-Related Cysteine Protease Caspase 1AreaBeta Proprotein Interleukin 1Body TissuesCASP-1CASP1CASP1 geneCalibrationCaspase-1Caspase-1 GeneCefazolinCell BodyCell ShapeCell SizeCell WallCell divisionCellsCessation of lifeCytosolDataDeathDefectEnzyme GeneEnzymesEquilibriumGene DeletionGenus staphylococcusGlucosaminidaseGlycansGoalsGrantHealthHost DefenseHumanICE ProteaseIL-1 betaIL-1 beta ConvertaseIL-1 beta-Converting EnzymeIL-1 βIL-1-bIL-1BCIL-1b Converting EnzymeIL-1βIL1-BetaIL1-βIL1B ProteinIL1B-ConvertaseIL1BCIL1BCEIL1F2IL1βImmuneImmune responseImmune systemImmunesInfectionInfectious Skin DiseasesInflammasomeInflammationInflammatoryInflammatory ResponseInnate Immune ResponseInnate Immune SystemInnate ImmunityInterleukin 1-B Converting EnzymeInterleukin 1-Beta ConvertaseInterleukin 1betaInterleukin-1 Beta Converting EnzymeInterleukin-1 Converting EnzymeInterleukin-1 betaInterleukin-1βKnowledgeLengthMacrophageMediatingMediatorMiceMice MammalsMicrobeMiscellaneous AntibioticModelingModern ManModificationMolecularMureinMurineMusMφNative ImmunityNatural ImmunityNon-Specific ImmunityNonspecific ImmunityOutcomePathogenesisPathologicPathologyPathway interactionsPattern recognition receptorPenicillin-Binding ProteinsPeptidoglycanPolysaccharidesPreinterleukin 1 BetaProcessProductionPropertyPublic HealthPublishingReceptor ProteinReportingResistanceResolutionS aureusS. aureusS. aureus infectionShapesSkin TissueSoft Tissue InfectionsStaph aureusStaph aureus infectionStaphylococcusStaphylococcus aureusStaphylococcus aureus infectionSystemic infectionTestingTimeTissuesVirulenceanti-microbialanti-microbial resistantantimicrobialbacterial disease treatmentbacterial infectious disease treatmentbalancebalance functioncell envelopeclinical relevanceclinically relevantcrosslinkcutaneous infectioncutaneous tissuecytokinedefined contributionenvironmental stressesenvironmental stressorgene deletion mutationhost responseimmune system responseimmunoresponsein vitro Assayin vivoinfected skininfected with S. aureusinfected with Staph aureusinfected with Staphylococcus aureusinfectious disease treatmentinsightmutantpathogenpathwayrapid detectionreceptorresistance to anti-microbialresistantresistant to antimicrobialresolutionsresponsescreeningscreeningssensorskin infectionsoft tissuetherapeutic target
Description preview
Project Summary
Infections caused by Staphylococcus aureus remain one of the most significant burdens to human health with
~750,000 associated deaths worldwide reported in 2019; a third of which were directly attributed to antimicrobial
resistance. Many therapeutics that target peptidoglycan synthesis are ineffective against S. aureus on account…
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