grant
Bacteria sensory transduction from gut to brain to modulate behavior
NIHUS FederalResearch GrantFY2025AcuteAnimalsAppetiteAssayBacteriaBehaviorBehavior DisordersBioassayBiological AssayBrainBrain Nervous SystemBrain StemBrainstemCalciumCell BodyCell Communication and SignalingCell SignalingCellsChemicalsClinicColonCommunicationCranial Nerve XDataDesire for foodDietDiseaseDisorderDissociationEatingElectrophysiologyElectrophysiology (science)Emotional well beingEncephalonEpithelial CellsEpitheliumFeels wellFiberFlagellinFood IntakeFoundationsGerm-FreeGoalsHumanHyperphagiaImmune signalingIntracellular Communication and SignalingKnock-outKnockoutKnowledgeLaboratoriesLearningLigandsLinkMetabolicMetabolic DiseasesMetabolic DisorderMiceMice MammalsMicrobeModelingModern ManMolecularMsecMurineMusNerve CellsNerve Impulse TransmissionNerve TransmissionNerve UnitNervous SystemNeural CellNeurocyteNeurologic Body SystemNeurologic Organ SystemNeuronal TransmissionNeuronsNeurophysiology / ElectrophysiologyNormal mental conditionNormal mental stateNormal psycheNutrientObesityOrganoidsOvereatingPainPainfulPathway interactionsPatternPerfusionPneumogastric NervePositive ValencePsyche structurePsychological Well BeingR-Series Research ProjectsR01 MechanismR01 ProgramReceptor ProteinReporterResearch GrantsResearch Project GrantsResearch ProjectsRewardsRoleRouteSense of well-beingSensorySignal TransductionSignal Transduction SystemsSignalingSmall IntestinesStimulusSweetenersSweetening AgentsSynapsesSynapticSystemTIL3TLR5TLR5 geneTLR5 receptorTenth Cranial NerveTestingTherapeuticThesaurismosisTimeToll-Like Receptor 5Toll/Interleukin-1 Receptor-Like Protein 3TransducersTranslatingTransplantationVagus NerveVagus nerve structureViralWell in selfWorkabsorptionadiposityaxon signalingaxon-glial signalingaxonal signalingbacteria in the gutbehavioral disorderbiological signal transductionconditioned place preferencecorpulencedesigndesigningdetection of nutrientdietary approachdietselectrophysiologicalemotional wellbeingemotional wellnessfood Ingestionfood consumptiongastrointestinalglia signalingglial signalinggut bacteriagut healthgut microbesgut microbial speciesimprovedin vivointestinal microbeslabeled by a rabies viruslabeled with rabiesmentalmental well-beingmental wellbeingmental wellnessmetabolism disordermicrobialmillisecondnerve signalingneuralneural circuitneural circuitryneural signalingneurocircuitryneuronalneuronal signalingneurotransmissionnutrient sensingoptogeneticspathwayperception of nutrientsplace conditioningpolyphagiapreferencepsychological wellbeingpsychological wellnessrabies labelrabies virus labelrabies virus labelingrabies virus mediated cellular labelingrabies virus to labelrational designreceptorreinforced behaviorresponseself wellnesssense of wellbeingsensory mechanismsmall bowelsocial rolesugarsynapsesynaptic circuitsynaptic circuitrytherapeutic targettoll-5 receptortransplant
Description preview
SUMMARY
Gut microbes are associated with disorders of behavior, including those related to food intake and appetite.
Obesity and hyperphagia can be transferred from donor to germ-free recipient mice, simply by microbial
transplants. However, the correlative effects seen in mice have yet to be translated to the clinic. There is a
critical need to…
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