grant
B. thuringiensis crystal proteins as powerful next-generation anthelmintics
Organization UNIV OF MASSACHUSETTS MED SCH WORCESTERLocation WORCESTER, UNITED STATESPosted 1 Apr 2005Deadline 30 Jun 2029
NIHUS FederalResearch GrantFY20250-11 years old21+ years oldA suumA. suumAccountingAdultAdult HumanAlbendazoleAllelesAllelomorphsAmino AcidsAncylostomaAncylostoma (genus)AncylostomatidaeAnemiaAnimalsAnthelminticsAntihelminthic AgentAntihelminthic DrugsAscarisAscaris suumAwardB subtilisB thuringiensisB. subtilisB. thuringiensisBacillus subtilisBacillus thuringiensisBacteriaBaking SodaCanine SpeciesCanis familiarisCarbonic Acid Monosodium SaltCaringChildChild YouthChildren (0-21)ClinicClinicalClinical TrialsCognitive DisturbanceCognitive ImpairmentCognitive declineCognitive function abnormalCollaborationsCricetinaeDALYDevelopmentDigestionDiseaseDisease VectorsDisorderDisturbance in cognitionDogsDogs MammalsDomestic HorseDoseDrug resistanceDrugsEarthEconomic IncomeEconomical IncomeEducationEducational aspectsEngineeringEquineEquine SpeciesEquus caballusEquus przewalskiiFamily suidaeFoodFormulationFoundationsFutureGeneralized GrowthGoalsGrowthGuidelinesHaemonchusHamstersHamsters MammalsHandHelminthsHookwormsHorsesHumanHybridsImmune responseImpaired cognitionIn VitroIn vivo analysisIncomeIndustrializationIndustry CollaborationIndustry CollaboratorsInfectionInsectaInsecticidesInsectsInsects InvertebratesIvermectinJapaneseLeadMalnutritionMeasuresMedicalMedicationMiceMice MammalsMilkModelingModern ManMorbidityMorbidity - disease rateMulti-Drug ResistanceMultidrug ResistanceMultiple Drug ResistanceMultiple Drug ResistantMurineMusNatureNecatorNematodaNematodesNutritional DeficiencyOral AdministrationOral Drug AdministrationOvineOvisParasite resistanceParasitesParasitic WormsPb elementPersonsPharmaceutical PreparationsPhysical FitnessPigsPlanet EarthPregnant WomenProductionProductivityProteinsRecommendationResistanceResistance to Multi-drugResistance to MultidrugResistance to Multiple DrugResistant to Multiple DrugResistant to multi-drugResistant to multidrugRodentRodent ModelRodentiaRodents MammalsSafetySheepSodium BicarbonateSodium Hydrogen CarbonateSoilStomachSuidaeSwineSystemTestingTissue GrowthToxicologyTransgenic OrganismsTransmissionTrichocephalusTrichurisUndernutritionValidationVariantVariationVermifugesVertebrate AnimalsVertebratesWorkWorld Health Organizationadulthoodadverse pregnancy outcomeaminoacidantihelminthiccaninecognitive dysfunctioncognitive losscombatcostdevelopmentaldietary deficiencydisability-adjusted life yearsdomestic dogdrug resistantdrug/agentefficacy testingexpectant motherexpectant womenexpecting motherexpecting womenexperimentexperimental researchexperimental studyexperimentsfirst in manfirst-in-humangastricgastrointestinalhandsheavy metal Pbheavy metal leadhost responsehybrid proteinimmune system responseimmunoresponseimprovedimproved outcomein vitro Bioassayin vitro testingin vivoin vivo evaluationin vivo testingincomesindividuals who are pregnantintraoral drug deliverykidslead candidatemalnourishedmulti-drug resistantmultidrug resistantnext generationnutrition deficiencynutrition deficiency disordernutritional deficiency disorderontogenyparasite resistantpeople who are pregnantphysical impairmentporcinepre-clinical studypreclinical studypregnant femalespregnant motherspregnant peoplepregnant populationsproductivity lossresistance in parasiteresistance to Drugresistance to Parasiteresistantresistant parasiteresistant to Drugresistant to Parasiteroundwormsafety studysuidsynergismthose who are pregnanttransgenictransmission processvalidationsvertebratawomen who are pregnantyoungster
Description preview
New treatments are urgently needed for parasitic gastrointestinal nematodes (GINs; hookworms, whipworms,
roundworms) that infect ~1.5 billion people and cause significant morbidity in children, pregnant women, and
working adults. Mass drug administration with albendazole has not been curative, and there are limitations
with additional approaches…
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