grant
B Cell Specificity and Repertoire Across Tissues and Age
Organization COLUMBIA UNIVERSITY HEALTH SCIENCESLocation NEW YORK, UNITED STATESPosted 1 Jun 2013Deadline 30 Apr 2031
NIHUS FederalResearch GrantFY20262019 novel corona virus2019 novel coronavirus2019-nCoV2019-nCoV S protein2019-nCoV spike glycoprotein2019-nCoV spike protein21+ years oldAdultAdult HumanAgeAgingAlimentary CanalAnatomic SitesAnatomic structuresAnatomyAntibodiesAntibody RepertoireAntibody SpecificityAntibody-Secreting CellsAntigensB blood cellsB cellB cell differentiationB cell receptorB cell repertoireB cellsB lymphocyte differentiationB-Cell Antigen ReceptorB-Cell SubsetsB-CellsB-Lymphocyte SubsetsB-LymphocytesB-cellBacteriaBindingBloodBlood PlasmaBlood Plasma CellBlood Reticuloendothelial SystemBody TissuesBone MarrowBone Marrow Reticuloendothelial SystemC3d ReceptorsCD 21 AntigensCD21CD21 AntigensCOVID-19 S proteinCOVID-19 spikeCOVID-19 spike glycoproteinCOVID-19 spike proteinCOVID-19 virusCOVID19 virusCR2CR2 ReceptorsCell BodyCell Growth and MaintenanceCell IsolationCell MaintenanceCell SegregationCell SeparationCell Separation TechnologyCellsCharacteristicsChildhoodChronicClass SwitchingClass SwitchingsClinical Treatment MoabCoV-2CoV2Complement 3d ReceptorsComplement Receptors 2DNADataData AnalysesData AnalysisDeoxyribonucleic AcidDigestive TractEpstein-Barr Virus ReceptorsFlow CytofluorometriesFlow CytofluorometryFlow CytometryFlow MicrofluorimetryFlow MicrofluorometryGI TractGastrointestinal TractGastrointestinal tract structureGrippeHerpesviridaeHerpesvirusesHumanHumoral ImmunitiesImaging ProceduresImaging TechnicsImaging TechniquesImmune responseImmunityImmunochemical ImmunologicImmunoglobulin Class SwitchingImmunoglobulin Class SwitchingsImmunoglobulin-Secreting CellsImmunologicImmunologicalImmunologicallyImmunologicsImmunologyInfectionInfluenzaIsotype SwitchingIsotype SwitchingsLengthLibrariesLungLung Respiratory SystemLymph Node Reticuloendothelial SystemLymph node properLymphatic TissueLymphatic cellLymphatic nodesLymphocyteLymphocyticLymphoid TissueMapsMeaslesMemoryMemory B CellMemory B-LymphocyteMiceMice MammalsModern ManMolecular InteractionMonoclonal AntibodiesMurineMusNeutralizing antibody assayPeptidesPhIP-seqPhage ImmunoPrecipitation SequencingPhenotypePlasmaPlasma CellsPlasma SerumPlasmacytesPopulationResidenciesReticuloendothelial System, Serum, PlasmaRubeolaSARS corona virus 2SARS-CO-V2SARS-COVID-2SARS-CoV-2SARS-CoV-2 SSARS-CoV-2 S proteinSARS-CoV-2 spikeSARS-CoV-2 spike glycoproteinSARS-CoV-2 spike proteinSARS-CoV2SARS-associated corona virus 2SARS-associated coronavirus 2SARS-coronavirus-2SARS-related corona virus 2SARS-related coronavirus 2SARSCoV2SerologySevere Acute Respiratory Coronavirus 2Severe Acute Respiratory Distress Syndrome CoV 2Severe Acute Respiratory Distress Syndrome Corona Virus 2Severe Acute Respiratory Distress Syndrome Coronavirus 2Severe Acute Respiratory Syndrome CoV 2Severe Acute Respiratory Syndrome-associated coronavirus 2Severe Acute Respiratory Syndrome-related coronavirus 2Severe acute respiratory syndrome associated corona virus 2Severe acute respiratory syndrome coronavirus 2Severe acute respiratory syndrome coronavirus 2 S proteinSevere acute respiratory syndrome coronavirus 2 spike glycoproteinSevere acute respiratory syndrome coronavirus 2 spike proteinSevere acute respiratory syndrome related corona virus 2SiteSortingSpecificitySpleenSpleen Reticuloendothelial SystemSystemT-CellsT-LymphocyteTestingTetanus VaccineTissuesVaccine AntigenVaccinesVirusWuhan coronavirusadulthoodage associatedage associated alterationsage associated changesage correlatedage correlated alterationsage correlated changesage dependentage dependent alterationsage dependent changesage groupage induced alterationsage induced changesage linkedage relatedage related alterationsage related changesage specificage specific alterationsage specific changesagesaging associated alterationsaging associated changesaging correlated alterationsaging correlated changesaging dependent alterationsaging dependent changesaging induced alterationsaging induced changesaging related alterationsaging related changesaging specific alterationsaging specific changesalimentary tractalterations with ageantibody-based immunityantigen bindingantigen boundcell sortingchanges with agecoronavirus disease 2019 S proteincoronavirus disease 2019 spike glycoproteincoronavirus disease 2019 spike proteincoronavirus disease 2019 viruscoronavirus disease-19 virusdata interpretationdeceased donordeceased organ donorsdigestive canalflow cytophotometryglobal gene expressionglobal transcription profilehCoV19herpes virushigh definitionhigh-resolutionhost responsehuman pathogenhuman tissueimmune system responseimmunogenimmunoresponseinnovateinnovationinnovativelife spanlifespanlymph celllymph glandlymph nodeslymph organlymphatic organlymphnodeslymphoid organmAbsmonoclonal Absmorbillimucosal sitenCoV2neutralizing antibody testpathogenpediatricplasmocyteposthumous donorsposthumous organ donorrespiratoryspatial RNA sequencingspatial gene expression analysisspatial gene expression profilingspatial resolved transcriptome sequencingspatial transcriptome analysisspatial transcriptome profilingspatial transcriptome sequencingspatial transcriptomicsspatially resolved transcriptomicsspatio transcriptomicsspike proteins on SARS-CoV-2telomerethymus derived lymphocytetissue tropismtranscriptome
Description preview
SUMMARY
Immune responses need to occur in diverse anatomical sites to provide protective immunity to pathogens with
different infection and tissue tropism characteristics throughout the human lifespan. B cells and plasma cells
responsible for humoral immunity show differences in phenotypic subsets in primary and secondary lymphoid
tissues, mucosal…
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