grant
B cell Response to Respiratory Viruses
Organization NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASESLocation UNITED STATES
NIHUS FederalResearch GrantFY2025AntibodiesAntibody ResponseAntigenic DeterminantsAntigensAvian InfluenzaB blood cellsB cellB cell receptorB cell repertoireB cellsB-Cell Antigen ReceptorB-Cell EpitopesB-CellsB-Lymphocyte EpitopesB-LymphocytesB-cellBinding DeterminantsBiological AgentBiological ProductsBird FluBlood SampleBlood specimenBovine SpeciesCattleCell IsolationCell LineageCell SegregationCell SeparationCell Separation TechnologyClinical Treatment MoabClinical TrialsCollaborationsConduct Clinical TrialsDairyingDevelopmentDomestic FowlsEarly-Stage Clinical TrialsEpitope MappingEpitopesEvolutionExposure toFerritinFowl PestFowl PlagueFutureGoalsGrippeH2N2H2N2 VirusH5 hemagglutininH5N1H5N1 virusHeadHemagglutininHumanImmune GlobulinsImmune responseImmunityImmunobiologyImmunoglobulinsImmunophysiologyIndividualInfectionInfluenzaInfluenza A H5N1Influenza A Virus, H2N2 SubtypeInfluenza A Virus, H5N1 SubtypeInfluenza HAInfluenza HemagglutininInfluenza VaccinesInfluenza VirusLifeMapsMemory B CellMemory B-LymphocyteModern ManMonoclonal AntibodiesPathogenicityPhase 1 Clinical TrialsPhase I Clinical TrialsPhenotypePopulationPoultryPropertyProteinsPublic HealthRecombinantsReportingRiskSamplingSiteTechnologyTimeVaccine ResearchVaccinesVirusWorkZoonosesZoonoticZoonotic Infectionavian fluavian influenza H5N1avian influenza H5N1 virusavian strains of influenzabiologicsbiopharmaceuticalbiotherapeutic agentbovidbovinecell sortingcowcross reactivitydevelopmentalemergent pandemicemerging pandemicfarm workerfarmworkerfirst in manfirst-in-humanflu HAflu hemagglutininflu serotypeflu strainflu subtypeflu vaccineflu viral strainflu virus pandemicflu virus strainflu virus vaccinefuture pandemichost responseimmune system responseimmunogenimmunoresponseinfluenza in birdsinfluenza serotypeinfluenza straininfluenza subtypeinfluenza viral HAinfluenza viral hemagglutinininfluenza viral straininfluenza virus HAinfluenza virus hemagglutinininfluenza virus pandemicinfluenza virus straininfluenza virus vaccineinfluenzavirusmAbsmonoclonal Absnano particlenano-sized particlenanoparticlenanosized particleneutralizing mAbneutralizing monoclonal antibodiesnew pandemicnext pandemicnovel pandemicpandemicpandemic diseasepandemic flupandemic influenzapandemic strain of influenzapathogenperipheral bloodphase I protocolrespiratory virusresponseseasonal fluseasonal influenzastemvaccine against fluvaccine against influenzavaccine responsevaccine responsivenessvaccine-induced responsevaccine-related research
Description preview
The B cell Immunobiology Section has evaluated the B cell response in multiple human Phase I clinical trials with experimental influenza vaccines conducted at the Vaccine Research Center with the goal of evaluating the magnitude and quality of the B cell response and mapping B cell epitopes on influenza proteins that could lead to greater…
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