grant
Autoinducer-2 and depression
Organization UNIVERSITY OF MIAMI SCHOOL OF MEDICINELocation CORAL GABLES, UNITED STATESPosted 1 Dec 2024Deadline 30 Nov 2029
NIHUS FederalResearch GrantFY2025AI-2 autoinducerAffectBacteriaBehaviorBehavior ControlBehavioral ManipulationBrainBrain Nervous SystemCancersCardiovascular DiseasesCatecholamine ReceptorCatecholaminesCell BodyCell Communication and SignalingCell CountCell DensityCell NumberCell SignalingCellsCellular Immune FunctionChemicalsChronic stressCommunicationCommunitiesComplexCorticosteroneDendritic SpinesDevelopmentDiseaseDisorderE coliE. coliEncephalonEndocrine Gland SecretionEngineeringEnvironmentEscherichia coliGI microbiomeHormonesHortega cellImmuneImmune responseImmune systemImmunesImmunityIndividualInfectionInfiltrationInterleukinsInterventionIntracellular Communication and SignalingKnowledgeMalignant NeoplasmsMalignant TumorMediatingMental DepressionMental disordersMental health disordersMiceMice MammalsMicrobial BiofilmsMicrogliaMurineMusN-octanoyl-L-homoserine lactoneNatureNerve CellsNerve Transmitter SubstancesNerve UnitNeural CellNeurobiologyNeurocyteNeuroendocrineNeuroendocrine SystemNeuronsNeurosecretory SystemsNeurotransmittersPathway interactionsPhysiologicPhysiologicalPhysiologyPoisonPredispositionProductionPsychiatric DiseasePsychiatric DisorderRegulationRiskRoleShotgun SequencingSignal PathwaySignal TransductionSignal Transduction SystemsSignalingSignaling MoleculeStressSusceptibilitySympathinsSystemTestingTherapeuticTherapeutic HormoneToxic ChemicalToxic SubstanceTransgenic MiceVAI-2alter microbiomeautoinducer 2behavior responsebehavioral controlbehavioral responsebeta-2 Adrenergic Receptorsbiofilmbiological adaptation to stressbiological signal transductioncardiovascular disorderdendrite spinedensitydepressiondevelopmentaldigestive tract microbiomeenteric microbiomegastrointestinal microbiomegitter cellgut microbiomegut to brain axisgut-associated microbiomegut-brain axisgut-brain communicationgut-brain interactionsgut-brain relationshipgut-brain signalinghost responseimmune functionimmune system responseimmunoresponseinnovateinnovationinnovativeintestinal biomeintestinal microbiomeluminescencemalignancymental illnessmesogliametabolism measurementmetabolomicsmetabonomicsmicrobial consortiamicrobial floramicrobiome adaptationmicrobiome alterationmicrobiome community compositionmicrobiome compositionmicrobiome perturbationmicrobiome species compositionmicrobiome structuremicrobiotamicrofloramicroglial cellmicrogliocytemultispecies consortianeoplasm/cancerneurobiologicalneuronalnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynovelnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachpathwayperivascular glial cellpsychiatric illnesspsychological disorderquorum sensingreaction; crisisresponsesocial rolestress related disorderstress responsestress; reactiontoxic compoundβ-2 Adrenoceptorβ2 Adrenergic Receptor
Description preview
Project Summary
Stress often has deleterious effects, particularly in the context of chronic stress, when harm to the individual
occurs and often leads to the development of psychiatric diseases. A better understanding of mechanisms
mediating stress is critically needed to develop new interventions. In this project, we propose to determine if…
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