grant
Autoimmunity-Associated B Cells in Lupus Nephritis
Organization UNIVERSITY OF ROCHESTERLocation ROCHESTER, UNITED STATESPosted 16 Jun 2023Deadline 31 May 2028
NIHUS FederalResearch GrantFY2025ATAC sequencingATAC-seqATACseqAccelerationAddressAffectAssay for Transposase-Accessible Chromatin using sequencingAutoantibodiesAutoimmune DiseasesAutoimmune StatusAutoimmunityB blood cellsB cellB cell differentiationB cellsB lymphocyte differentiationB-Cell ActivationB-CellsB-LymphocytesB-cellBLIMP1Basal Transcription FactorBasal transcription factor genesBiometricsBiometryBiostatisticsBloodBlood Plasma CellBlood Reticuloendothelial SystemBody TissuesCD11CD11 AntigensCD11cCell BodyCell Communication and SignalingCell LineageCell SignalingCellsCellular biologyChromosomesCollaborationsDataDevelopmentDevelopment PlansDevelopment and ResearchDiseaseDisorderDoctor of PhilosophyDysfunctionEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessEventFDA Drug ApprovalFamilyFlow CytofluorometriesFlow CytofluorometryFlow CytometryFlow MicrofluorimetryFlow MicrofluorometryFood and Drug Administration Drug ApprovalFosteringFrequenciesFunctional disorderFundingGene ExpressionGeneral Transcription Factor GeneGeneral Transcription FactorsGenesHumanIFNIFN activationIFN-GammaIFN-gIFN-γIFNGIFNγIL21IRF4IRF4 geneITGAXITGAX geneImmuneImmune InterferonImmunesImmunohistochemistryImmunohistochemistry Cell/TissueImmunohistochemistry Staining MethodIn SituIn VitroInstitutionInterferon ActivationInterferon GammaInterferon Regulatory Factor 4Interferon Type IIInterferonsIntracellular Communication and SignalingInvestigatorsKidneyKidney TubulesKidney Urinary SystemLSIRF ProteinLiteratureLupusLupus Erythematosus DisseminatusLupus GlomerulonephritisLupus NephritisLymphatic cellLymphocyteLymphocyticMapsMeasuresMedicineMentorshipModern ManMolecularMultiple Myeloma Oncogene 1National Institutes of HealthNuclearOrganPRDI-BF1PRDM1PRDM1 geneParticipantPathogenesisPathogenicityPathologyPathway interactionsPatientsPh.D.PhDPhasePhosphorylationPhysiopathologyPlasma CellsPlasma EnhancementPlasmacytesPopulationPositionPositioning AttributeProceduresProductionProtein PhosphorylationR & DR&DRNA SeqRNA sequencingRNAseqRefractoryRenal tubule structureResearchResearch PersonnelResearchersRoleSLESTAT1STAT1 geneSTAT91Signal TransductionSignal Transduction SystemsSignalingSingle cell seqSystemSystemic Lupus ErythematosusSystemic Lupus ErythematousSystemic Lupus ErythmatosusT-CellsT-LymphocyteT-bet proteinT-bet transcription factorTLR7TLR7 geneTechniquesTestingTimeTissue SampleTissuesToll-Like Receptor 7Transcription Factor Proto-OncogeneTranscription factor genesUnited States National Institutes of HealthUniversitiesWomanWorkactivated B cellsassay for transposase accessible chromatin followed by sequencingassay for transposase accessible chromatin seqassay for transposase accessible chromatin sequencingassay for transposase-accessible chromatin with sequencingautoimmune antibodyautoimmune conditionautoimmune disorderautoimmune reactivityautoimmunity diseaseautoreactive antibodyautoreactivitybiological signal transductioncareer developmentcell biologyclinical relevanceclinically relevantcytokinedevelopmentaldisseminated lupus erythematosusepigenetic regulationepigeneticallyepigenomicsexperienceflow cytophotometryglobal gene expressionglobal transcription profilehuman diseasehuman tissuein vivoindexinginterleukin-21kidney biopsylFN-Gammalarge data setslarge datasetslymph cellnew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapeutic targetnew therapy approachesnew therapy targetnew treatment approachnew treatment strategynovelnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapeutic targetnovel therapy approachnovel therapy targetpathophysiologypathwayperipheral bloodphase 2 studyphase II studyplasma cell developmentplasma cell differentiationplasmocyteprecursor cellprogramsrenalrenal biopsyrenal tubuleresearch and developmentscRNA sequencingscRNA-seqself reactive antibodysingle cell RNA-seqsingle cell RNAseqsingle cell analysissingle cell expression profilingsingle cell next generation sequencingsingle cell sequencingsingle cell transcriptomic profilingsingle-cell RNA sequencingskillssocial rolespatial RNA sequencingspatial gene expression analysisspatial gene expression profilingspatial resolved transcriptome sequencingspatial transcriptome analysisspatial transcriptome profilingspatial transcriptome sequencingspatial transcriptomicsspatially resolved transcriptomicsspatio transcriptomicssystemic lupus erythematosistherapeutic targetthymus derived lymphocytetranscription factortranscriptometranscriptome sequencingtranscriptomic sequencingtranscriptomics
Description preview
PROJECT SUMMARY/ABSTRACT
This proposal details a five-year research and career development plan with a scientific focus on
autoimmunity-associated B cells (ABC), a subset of cells that is expanded during lupus disease activity and
can differentiate into autoantibody-producing plasma cells (PC). These cells are found in the kidneys of lupus…
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