grant
Attentional Resilience in Older Adults
NIHUS FederalResearch GrantFY2025AD associated neurodegenerationAD dementiaAD neurodegenerationAD pathologyAcuteAgeAgingAlzheimer Type DementiaAlzheimer associated neurodegenerationAlzheimer disease dementiaAlzheimer related neurodegenerationAlzheimer risk factorAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's DiseaseAlzheimer's biomarkerAlzheimer's disease associated neurodegenerationAlzheimer's disease biological markerAlzheimer's disease pathologyAlzheimer's disease related neurodegenerationAlzheimer's disease riskAlzheimer's pathologyAlzheimers DementiaAlzheimer’s biological markerAlzheimer’s disease biomarkerAmentiaAttentionAttentional deficitBiological MarkersBloodBlood Reticuloendothelial SystemBrainBrain Nervous SystemChronicChronic stressCognitionCognitiveCognitive DisturbanceCognitive ImpairmentCognitive declineCognitive function abnormalCompensationDarknessDataDeliriumDementiaDisturbance in cognitionDorsalEEGElectroencephalogramElectroencephalographyEncephalonEnvironmentEvaluationEvent-Related PotentialsEyeEyeballFunctional MRIFunctional Magnetic Resonance ImagingFutureGoalsHeadImpaired cognitionIncidenceIndividualInflammationInjuryInterventionLinkMT-bound tauMeasurementMeasuresMediatingMediatorNatural experimentNerve CellsNerve UnitNeural CellNeural PathwaysNeurocyteNeuronal InjuryNeuronsOperative ProceduresOperative Surgical ProceduresOutcomePathologyPatientsPatternPerformancePostoperativePostoperative PeriodPrimary Senile Degenerative DementiaProcessResearch ResourcesResourcesRestRiskRisk FactorsScheduleSensoryStimulusStressSurgicalSurgical InterventionsSurgical ProcedureSystemTauopathiesTestingVisualWorkagesaging resiliencealzheimer riskattentional controlattentive deficitattenuationbio-markersbiologic markerbiomarkerbiomarker arraybiomarker panelclinical validationcognitive assessmentcognitive dysfunctioncognitive functioncognitive losscognitive performancecognitive taskcognitive testingconfusion assessment methoddeliriousdevelop therapydirected attentiondirects attentionevent related potentialexecutive controlexecutive functionexperiencefMRIinattentioninattentivenessinjuredinjuriesinsightintervention developmentmarker panelmicrotubule bound taumicrotubule-bound taunerve injuryneuralneural circuitneural circuitryneural controlneural inflammationneural injuryneural mechanismneural regulationneurocircuitryneuroinflammationneuroinflammatoryneuromechanismneuromodulationneuromodulatoryneuron injuryneuronalneuropathologic tauneuropathological tauneuroregulationolder adultolder adulthoodperceptual stimulusperformance testsphysicochemical phenomena related to the sensesphysiologic stressesphysiologic stressorphysiological stressespre-clinicalpreclinicalpreservationprimary degenerative dementiaresilienceresilience during agingresilience in agingresilience in normal agingresilience to agingresilience with agingresilientresilient agingresilient to agingresponsesenile dementia of the Alzheimer typesensory stimulussexstressorsurgerysynaptic circuitsynaptic circuitrytautau Proteinstau associated neurodegenerationtau associated neurodegenerative processtau driven neurodegenerationtau factortau induced degenerationtau induced neurodegenerationtau mediated neurodegenerationtau neurodegenerative diseasetau neuropathologytau pathologytau pathophysiologytau proteinopathytau related neurodegenerationtau-induced pathologytauopathic neurodegenerative disordertauopathytherapy developmenttooltreatment developmentvisual stimulusτ Proteins
Description preview
In delirium and Alzheimer’s disease (AD), which increase the risk for each other, patients suffer deficits in
executive functions, including attentional control. There is a critical gap in our understanding of the mecha-
nisms by which attentional control capacity may promote cognitive resilience in both delirium and dementia.
Even under normal…
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