grant
Atrial and blood JNK in Postoperative AF
Organization OHIO STATE UNIVERSITYLocation Columbus, UNITED STATESPosted 14 Apr 2023Deadline 31 Jan 2028
NIHUS FederalResearch GrantFY2026(TNF)-αAbnormal CellAbscissionAffectAgeAgingAlcohol Chemical ClassAlcohol DrinkingAlcohol consumptionAlcoholsAnimal ModelAnimal Models and Related StudiesAntimorphic mutationAortocoronary BypassApoplexyArrhythmiaAssayAtrialAtrial FibrillationAuricular FibrillationBeta Proprotein Interleukin 1BioassayBiochemicalBiochemistryBiological AssayBiological ChemistryBiological MarkersBloodBlood PlasmaBlood Reticuloendothelial SystemBlood SampleBlood specimenBody TissuesBrain Vascular AccidentC-jun Amino-Terminal KinaseC-jun Kinase-1C-jun N-Terminal Kinase 1CachectinCardiacCardiac ArrhythmiaCardiac AtriumCardiac SurgeryCardiac Surgery proceduresCardiovascular DiseasesCell CommunicationCell InteractionCell-to-Cell InteractionCellular StressCellular Stress ResponseCerebral StrokeCerebrovascular ApoplexyCerebrovascular StrokeClinicClinicalClinical MarkersClinical ResearchClinical StudyCollaborationsComplicationCoronary Artery BypassCoronary Artery Bypass GraftingCoronary Artery Bypass SurgeryCoronary arterial bypassCouplingDataDevelopmentDiseaseDisorderDomestic RabbitDominant NegativeDominant-Negative MutantDominant-Negative MutationDysfunctionElderlyElectrophysiologyElectrophysiology (science)ElementsEtOH drinkingEtOH useEventExcisionExhibitsExperimental DesignsExtirpationFoundationsFunctional disorderFundingFutureGene ModifiedGene TransferGenesGoalsHealth Care CostsHealth CostsHeartHeart ArrhythmiasHeart AtriumHeart ResearchHeart Surgical ProceduresHeart failureHistoryHospitalsHumanIL-1 betaIL-1 βIL-1-bIL-1βIL1-BetaIL1-βIL1B ProteinIL1F2IL1βImageImpairmentIncidenceInflammationInflammatoryInflammatory ResponseInjuryInterleukin 1betaInterleukin-1 betaInterleukin-1βInternetInterventionIschemiaIsoformsJN KinaseJNKJNK Mitogen-Activated Protein KinasesJNK-55JNK1JNK1 KinaseJNK1 proteinJNK1A2JNK2JNK2 KinaseJNK2 Stress-Activated Protein KinaseJNK21B1/2JNK2AJNK2AlphaJNK2BJNK2BetaKinasesKnowledgeLinkMAP Kinase 8MAP Kinase 8 GeneMAPK8MAPK8 Mitogen-Activated Protein KinaseMAPK8 geneMAPK9MAPK9 Mitogen-Activated Protein KinaseMAPK9 geneMacrophage-Derived TNFMeasuresMedical centerMiceMice MammalsMitogen-Activated Protein Kinase 8Mitogen-Activated Protein Kinase 9Modern ManMonocyte-Derived TNFMorbidityMurineMusMuscle CellsMyocytesN-terminalNH2-terminalNeurophysiology / ElectrophysiologyObesityOperative ProceduresOperative Surgical ProceduresOryctolagus cuniculusOutcomePRKM8PRKM9PaintPathogenesisPatient outcomePatient-Centered OutcomesPatient-Focused OutcomesPatientsPhosphotransferase GenePhosphotransferasesPhysiopathologyPilot ProjectsPlasmaPlasma SerumPopulationPostoperativePostoperative PeriodPredisposing FactorPredispositionPreinterleukin 1 BetaPreventionProceduresPropertyProtein IsoformsProteinsPumpRabbitsRabbits MammalsRecording of previous eventsRemovalReportingReticuloendothelial System, Serum, PlasmaRetrospective cohort studyRiskRisk FactorsRyR2SAP Kinase-1SAPK/JNKSAPK1 Mitogen-Activated Protein KinaseSAPK1/JNKSeriesStimulusStressStress TestsStress-Activated Protein Kinase JNK1Stress-Activated Protein Kinase gammaStrokeSurgeonSurgicalSurgical InterventionsSurgical ProcedureSurgical RemovalSusceptibilityTNFTNF ATNF AlphaTNF geneTNF-αTNFATNFαTechniquesTestingTherapeuticThoracic SurgeryThoracic Surgical ProceduresTimeTissue SampleTissuesTransphosphorylasesTumor Necrosis FactorTumor Necrosis Factor-alphaWWWWorkadiposityadvanced ageagedagesalcohol exposedalcohol exposurealcohol ingestionalcohol intakealcohol product usealcohol usealcoholic beverage consumptionalcoholic drink intakeatriumbio-markersbiologic markerbiological adaptation to stressbiomarkerbrain attackc-jun Kinase-2c-jun N-Terminal Kinasecardiac failurecardiac researchcardiovascular disordercell stresscerebral vascular accidentcerebrovascular accidentchest surgeryclinical biomarkersclinical significanceclinically significantclinically useful biomarkerscoronary bypasscorpulencecostcytokinedeath riskdevelopmentalelectrophysiologicalethanol consumptionethanol drinkingethanol exposedethanol exposureethanol ingestionethanol intakeethanol product useethanol useexosomeexposed to alcoholexposed to ethanolexposure to alcoholexposure to ethanolgap junction channelgene modificationgenetically modifiedgeriatricheart cellheart surgeryhigh riskhistorieshuman modelimagingin vivoinjuriesinnovateinnovationinnovativejun-NH2-Terminal Kinasemodel of animalmodel of humanmortalitymortality riskmouse modelmurine modelnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovelnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapyoverexpressoverexpressionp54aSAPKparticlepathophysiologypatient biomarkerspatient oriented outcomespilot studypreventpreventingprospectivereaction; crisisresectionresponsesenior citizensexstress responsestress-activated protein kinase 1stress; reactionstrokedstrokessurgerysurgery outcomesurgical outcometherapeutic targettranslational opportunitiestranslational potentialwebworld wide web
Description preview
Atrial fibrillation (AF) is the most common arrhythmia and has a high risk of mortality and morbidities. Among the
general AF population, new-onset postoperative atrial fibrillation (POAF) is the most common complication after open-
heart surgery, which significantly increased mortality and amplifies hospital and patient costs. The mechanisms…
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