grant
Astrocytes as governing pathological drivers of neurovascular dysfunction in AD
Organization MASSACHUSETTS GENERAL HOSPITALLocation BOSTON, UNITED STATESPosted 1 Mar 2017Deadline 29 Feb 2028
NIHUS FederalResearch GrantFY2026AD dementiaAD modelAD pathologyAPP-PS1APP/PS1AbscissionAgingAlzheimer Type DementiaAlzheimer beta-ProteinAlzheimer disease dementiaAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's Amyloid beta-ProteinAlzheimer's DiseaseAlzheimer's amyloidAlzheimer's disease modelAlzheimer's disease pathologyAlzheimer's pathologyAlzheimers DementiaAmentiaAmyloidAmyloid (Aβ) plaquesAmyloid Alzheimer's Dementia Amyloid ProteinAmyloid Beta-PeptideAmyloid PlaquesAmyloid Protein A4Amyloid SubstanceAmyloid beta-ProteinAmyloid βAmyloid β oligomerAmyloid β-PeptideAmyloid β-ProteinAmyloidosisAstrocytesAstrocytusAstrogliaAutoregulationAβAβOBBB functionBlood - brain barrier anatomyBlood VesselsBlood capillariesBlood flowBlood-Brain BarrierBrainBrain Nervous SystemCNS Nervous SystemCalciumCalcium Ion SignalingCalcium SignalingCausalityCause of DeathCell BodyCellsCentral Nervous SystemCerebrovascular CirculationChronicCognitive DisturbanceCognitive ImpairmentCognitive declineCognitive function abnormalCommunicationComplexDegenerative Neurologic DisordersDementiaDepositDepositionDeteriorationDevelopmentDiseaseDisorderDisturbance in cognitionDysfunctionEncephalonEtiologyEvolutionExcisionExtirpationFunctional disorderGliaGlial CellsGlutamatesHealthHealth BenefitHealth protectionHemato-Encephalic BarrierHomeostasisHumanHyperemiaImageImaging DeviceImaging InstrumentImaging ToolImpaired cognitionIn vivo two-photon calcium imagingIndividualK elementKolliker's reticulumL-GlutamateMaintenanceMediatingMetabolicMiceMice MammalsModern ManMolecularMurineMusNerve CellsNerve DegenerationNerve UnitNervous System Degenerative DiseasesNeural CellNeural Degenerative DiseasesNeural TransmissionNeural degenerative DisordersNeuraxisNeuritic PlaquesNeurocyteNeurodegenerative DiseasesNeurodegenerative DisordersNeurofibrillary TanglesNeurogliaNeuroglial CellsNeurologicNeurologic Degenerative ConditionsNeurologicalNeuron DegenerationNeuronal DysfunctionNeuronsNeurovascular dysfunctionNon-neuronal cellNonneuronal cellOsmosisPathogenesisPathologicPhotic StimulationPhysiological HomeostasisPhysiopathologyPlayPotassiumPreparationPrimary Senile Degenerative DementiaProcessRegulationRemovalReporterRoleSenile PlaquesSleepSurgical RemovalSynapsesSynapticSynaptic TransmissionSystemTestingTherapeuticUnited StatesVisual CortexVisual StimulationWakefulnessWaste Productsa beta peptideabetaabeta oligomeralzheimer modelamyloid betaamyloid beta oligomeramyloid beta plaqueamyloid diseaseamyloid-b plaqueamyloid-b proteinastrocytic gliaawakeaβ oligomeraβ plaquesbeta amyloid fibrilblood flow in brainblood-brain barrier functionbloodbrain barrierbloodbrain barrier functionbrain blood circulationbrain blood flowcapillarycausationcerebral blood flowcerebral circulationcerebrocirculationcerebrovascular blood flowcognitive dysfunctioncognitive losscored plaquedecline in functiondecline in functional statusdegenerative diseases of motor and sensory neuronsdegenerative neurological diseasesdevelopmentaldiffuse plaquedisease causationexperimentexperimental researchexperimental studyexperimentsfunctional declinefunctional status declineglutamatergicimagingimaging in vivoimprovedin vivoin vivo calcium imagingin vivo imaginginterstitiallife spanlifespanmouse modelmulti-photon imagingmultiphoton excitation microscopymultiphoton imagingmultiphoton microscopymurine modelnerve cementnetwork dysfunctionneural degenerationneural dysfunctionneural inflammationneuro-vascular couplingneuro-vascular unitneurodegenerationneurodegenerativeneurodegenerative illnessneurofibrillary degenerationneurofibrillary lesionneurofibrillary pathologyneuroinflammationneuroinflammatoryneurological degenerationneuronalneuronal degenerationneurovascular abnormalityneurovascular couplingneurovascular dysregulationneurovascular impairmentneurovascular pathologyneurovascular unitneurovasculopathynew approachesnew drug targetnew drug treatmentsnew druggable targetnew drugsnew pharmacological therapeuticnew pharmacotherapy targetnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapeutic targetnew therapeuticsnew therapynew therapy approachesnew therapy targetnew treatment approachnew treatment strategynext generation therapeuticsnovelnovel approachesnovel drug targetnovel drug treatmentsnovel druggable targetnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel pharmacotherapy targetnovel strategiesnovel strategynovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapeutic targetnovel therapeuticsnovel therapynovel therapy approachnovel therapy targetoAβoligomeric amyloid betaoligomeric amyloid-βpathophysiologypharmacologicpreparationspreventpreventingprimary degenerative dementiaresectionrestorationsenile dementia of the Alzheimer typesleep healthsleep hygienesleep wellnesssocial rolesoluble amyloid precursor proteinsynapsesynapse functionsynaptic functiontangletargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttherapeutic targettoolvascularvisual cortical
Description preview
Astrocytes as governing pathological drivers of neurovascular dysfunction in AD
Abstract:
Alzheimer’s Disease (AD) is a progressive and irreversible neurodegenerative disease, characterized by
cognitive decline. The pathogenesis of AD is complex, and the etiology has yet to be fully elucidated. The
pathological manifestations of AD involve amyloid…
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