grant
Association of Genetic Determinants of Diabetes with Cerebrovascular Disease in a Multi-ancestral Hawaiian Population
Organization UNIVERSITY OF HAWAII AT MANOALocation HONOLULU, UNITED STATESPosted 1 Aug 2017Deadline 30 Apr 2029
NIHUS FederalResearch GrantFY2025Adult-Onset Diabetes MellitusAgeApoplexyArchitectureBlood VesselsBrain TIABrain VascularBrain Vascular AccidentBrain Vascular DisordersCOBRECenter of Biomedical Research ExcellenceCenters of Research ExcellenceCerebral StrokeCerebrovascular ApoplexyCerebrovascular DiseaseCerebrovascular DisordersCerebrovascular StrokeClinicalClinical ResearchClinical StudyClinical geneticsCohort StudiesCommunitiesConcurrent StudiesDataData BasesDatabasesDerivationDerivation procedureDiabetes MellitusDiagnosisDiseaseDisorderDisparity populationEngineering / ArchitectureEnsureEpidemiologic ResearchEpidemiologic StudiesEpidemiological StudiesEpidemiologyEpidemiology ResearchEthnic GroupEthnic PeopleEthnic PopulationEthnic individualEthnicity PeopleEthnicity PopulationEuropeanEuropean ancestryEventFrequenciesFutureGWA studyGWASGeneticGenetic DeterminismGenetic DiversityGenetic PolymorphismGenetic ResearchGenetic RiskGenetic VariationGenetic studyGenomicsGenotypeGoalsHawaiian individualHawaiian peopleHawaiian populationHawaiiansHealthHealth systemHyperlipemiaHyperlipidemiaHypertensionIndividualInequityInstitutionInstructionIntracranial Vascular DiseasesIntracranial Vascular DisordersKetosis-Resistant Diabetes MellitusKnowledgeMaturity-Onset Diabetes MellitusMedicalMedical GeneticsMorbidityMorbidity - disease rateNIDDMNative HawaiianNative Hawaiian and Other Pacific IslanderNative Hawaiian and Pacific IslanderNative Hawaiian or Other Pacific IslanderNative Hawaiian or Pacific IslanderNon-Insulin Dependent DiabetesNon-Insulin-Dependent Diabetes MellitusNoninsulin Dependent DiabetesNoninsulin Dependent Diabetes MellitusObesityOutcomePacific IslandsParticipantPerformancePopulationPopulation GeneticsPopulation HeterogeneityPredisposition genePreventative interventionPublic HealthR-Series Research ProjectsR01 MechanismR01 ProgramRecoveryResearchResearch GrantsResearch Project GrantsResearch ProjectsRiskRisk FactorsRisk-associated variantSlow-Onset Diabetes MellitusStable Diabetes MellitusStrokeSusceptibility GeneT2 DMT2DT2DMTestingTherapeutic InterventionTransient Ischemic AttackTranslational ResearchTranslational ScienceType 2 Diabetes MellitusType 2 diabetesType II Diabetes MellitusType II diabetesUnderrepresented GroupsUnderrepresented PopulationsVariantVariationVascular Hypertensive DiseaseVascular Hypertensive DisorderWorkadiposityadult onset diabetesagesancestry analysisbiobankbiorepositorybrain attackbrain vascular diseasebrain vascular dysfunctioncerebral vascularcerebral vascular accidentcerebral vascular diseasecerebral vascular dysfunctioncerebro-vascularcerebrovascularcerebrovascular accidentcerebrovascular dysfunctioncohortcommunity engagementcorpulencedata basediabetesdiabetes riskdisadvantaged groupdisadvantaged individualdisadvantaged peopledisadvantaged populationdisadvantaged subgroupdisparities across groupsdisparity across subgroupsdisparity among groupsdisparity among subgroupsdisparity between groupsdisparity between subgroupsdiverse populationsengagement with communitiesepidemiologicepidemiologic investigationepidemiologicalepidemiology studyethnic subgroupethnicity groupexomegenetic architecturegenetic determinantgenome wide associationgenome wide association scangenome wide association studygenomewide association scangenomewide association studygroup disparitygroup inequalitygroup inequityhealth disparity communityhealth disparity grouphealth disparity populationsheterogeneous populationhigh blood pressurehyperpiesiahyperpiesishypertensive diseasehypertensive disorderinequalities among populationsinequalities between populationsinequalities in populationsinequality across populationsinequality among groupsinequality between groupsinequality in groupsinequities among populationsinequities between populationsinequities in populationsinequity across groupsinequity across populationsinequity between groupsinequity in groupsinnovateinnovationinnovativeinstrumentintervention for preventionintervention therapyintracranial vascular dysfunctionketosis resistant diabetesmaturity onset diabetesmini strokemini-strokemortalitymulti-ethnicmultidisciplinarymultiethnicnovelpolygenetic risk scorespolygenic risk scorepolymorphismpopulation diversitypopulation healthpopulation inequalitypopulation inequityprecision medicineprecision-based medicinepredisposing geneprevention interventionpreventional intervention strategypreventive interventionprospectiverisk allelerisk for strokerisk generisk genotyperisk locirisk locusrisk of strokerisk stratificationrisk variantstratify riskstroke riskstrokedstrokesstudy populationsubgroup disparitysusceptibility allelesusceptibility locussusceptibility varianttooltranslation researchtranslational geneticstranslational investigationtype 2 DMtype II DMtype two diabetesunder representation of groupsunder represented groupsunder represented peopleunder represented populationsunderrepresentation of groupsunderrepresented peopleunequal groupunequal populationvascularwhole genome association analysiswhole genome association studyyounger age
Description preview
PROJECT SUMMARY/ABSTRACT – Research Project Leader: Stacy Brown, MD
Association of Genetic Determinants of Diabetes with Cerebrovascular Disease in Multi-Ancestral Hawai'ian
Populations
Global increases in prevalent
type 2 diabetes (T2D)
and cerebrovascular disease means that health systems
need to meet increasing demand for preventive and…
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