grant
Assessment of thymic output in the context of genetics, environmental exposures, and progression to type 1 diabetes
Organization UNIVERSITY OF FLORIDALocation GAINESVILLE, UNITED STATESPosted 1 May 2026Deadline 30 Apr 2028
NIHUS FederalResearch GrantFY202610 year old10 years of age12-20 years old15 year old15 years of age21+ years oldAbscissionAccelerationAdolescenceAdolescentAdolescent YouthAdultAdult HumanAgeAge of OnsetAgingAntigen PresentationAssayAutoantibodiesAutoimmuneAutoimmune DiseasesAutoimmune MechanismAutoimmune ProcessB9 endocrine pancreasBioassayBiological AssayBiological MarkersBlood SerumBrittle Diabetes MellitusCC-1CC-3CCL13CCL13 geneCCL14CCL14 geneCKb1CKb10CXC chemokine receptor 3CXCR3 proteinCXCR3 receptorCancersChemokine (C-C Motif) Ligand 14Chemokine CC-1Chemokine CC-1/CC-3Chemokine CC-3Chemokine Receptor GeneChildhoodClinicClinicalClonal ExpansionComplexCryofixationCryopreservationDataDecision MakingDevelopmentDiabetes MellitusDiagnosisDiseaseDisease ProgressionDisorderEcological impactEmigrantEndocrine PancreasEnvironmentEnvironmental ExposureEnvironmental FactorEnvironmental ImpactEnvironmental Risk FactorEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessEpigenetic ageEventExcisionExtirpationFlow CytofluorometriesFlow CytofluorometryFlow CytometryFlow MicrofluorimetryFlow MicrofluorometryGeneticGenetic RiskGenomic DNAGroups at riskHCC-1HCC-1/HCC-3HCC-3HL-A AntigensHLA AntigensHeterogeneityHistologicHistologicallyHumanHuman Leukocyte AntigensIDDMImmuneImmune systemImmunesInbred NOD MiceIncidenceIndividualInfectionInflammationInflammatoryInsulin-Dependent Diabetes MellitusInterventionIslands of LangerhansIslets of LangerhansJuvenile-Onset Diabetes MellitusKetosis-Prone Diabetes MellitusLeukocyte AntigensLongitudinal StudiesLongitudinal SurveysMCIFMCP-4MGC17134MHC ReceptorMajor Histocompatibility Complex ReceptorMalignant NeoplasmsMalignant TumorMature T-CellMature T-LymphocyteMeasurementMemoryModelingModern ManNCC-1NCC-2NCC1NCC2NOD MouseNational Institutes of HealthNesidioblastsNon-Obese Diabetic MiceNonobese Diabetic MouseNutritionalOnset of illnessOrgan DonorOutputPBMCPancreatic IsletsPancreatic beta CellPancreatic β-CellPars endocrina pancreatisParticipantPathogenesisPatientsPediatric cohortPeople at riskPeripheralPeripheral Blood Mononuclear CellPersons at riskPhenotypePopulationPopulations at RiskPredispositionPrevalenceProductionRemovalReportingResearch SpecimenResearch SupportRiskSCYA13SCYA14SCYL1SCYL2SY14SamplingSerumShapesSmall Inducible Cytokine A14Small Inducible Cytokine Subfamily A (Cys-Cys), Member 14SpecificitySpecimenStimulusStressStructure of beta Cell of isletStudy SubjectSudden-Onset Diabetes MellitusSurgical RemovalSusceptibilityT memory cellT-Cell Antigen ReceptorsT-Cell ReceptorT-Cell SubsetsT-CellsT-LymphocyteT-Lymphocyte SubsetsT1 DMT1 diabetesT1DT1DMTestingThymectomyThymusThymus GlandThymus ProperThymus Reticuloendothelial SystemTimeType 1 Diabetes MellitusType 1 diabetesType I Diabetes MellitusUnited States National Institutes of HealthViral DiseasesVirus DiseasesWeaningWhole Bloodaccelerated agingaccelerated biological ageaccelerated biological agingadolescence (12-20)adulthoodage 10age 10 yearsage 15age 15 yearsage accelerationage associated alterationsage associated changesage correlated alterationsage correlated changesage dependent alterationsage dependent changesage induced alterationsage induced changesage related alterationsage related changesage specific alterationsage specific changesagesaging associated alterationsaging associated changesaging correlated alterationsaging correlated changesaging dependent alterationsaging dependent changesaging induced alterationsaging induced changesaging related alterationsaging related changesaging specific alterationsaging specific changesalterations with ageanalytical toolautoimmune antibodyautoimmune conditionautoimmune disorderautoimmunity diseaseautoreactive T cellautoreactive antibodybeta cell developmentbio-markersbiobankbiologic markerbiomarkerbiorepositorycase controlcase-controlledchanges with agechemokine receptorclinical relevanceclinically relevantcohortcold preservationcold storagecostdevelopmentaldiabetesdiabetes riskdisease onsetdisease riskdisorder onsetdisorder riskendocrine pancreas developmentenvironmental riskepigeneticallyexhaustexhaustionexposure to environmental agentsexposure to environmental factorsexposure to environmental stimuliexposure to environmental substancesfifteen year oldfifteen years of ageflow cytophotometrygDNAinsightinsulin dependent diabetesinsulin dependent type 1islet developmentjuvenilejuvenile diabetesjuvenile diabetes mellitusjuvenile humanketosis prone diabeteslong-term studylongitudinal outcome studieslongitudinal research studymalignancymemory T lymphocytemigrationmouse modelmurine modelneoplasm/cancernon-obese diabetic (NOD) micenonobese diabetic (NOD) micenovelnutritiouspancreas beta cellpancreas β cellpancreatic b-cellpediatricpolygenetic risk scorespolygenic risk scorepredictive toolsresectionresponsescreeningscreeningsself reactive antibodyself-reactive T cellseroconversionspecific biomarkersten year oldten years of agethymus derived lymphocytetype I diabetestype one diabetesviral infectionvirus infectionvirus-induced diseasewardyounger age
Description preview
Project Summary
Type 1 Diabetes is rising in incidence and is most commonly diagnosed before the age of 10,
predisposing patients to lifelong complications. The window for intervention is narrowing as the
overall mean age at diagnosis is decreasing with time. Although we can identify genetic risk for
T1D using polygenic risk scores, disease…
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