grant
Assessment of the Retinal Pigment Epithelial Cell Mosaic Based on Functional Imaging of Intracellular Pigment Dynamics in the Living Human Eye
Organization UNIVERSITY OF MARYLAND BALTIMORELocation BALTIMORE, UNITED STATESPosted 30 Sept 2025Deadline 31 Aug 2028
NIHUS FederalResearch GrantFY2025AddressAdvanced DevelopmentAffectAgeAge of OnsetAge related macular degenerationAge-Related MaculopathyAmericanAreaAwardBiogenesisBody TissuesCell BodyCell Communication and SignalingCell ExtractsCell FunctionCell PhysiologyCell ProcessCell SignalingCellsCellular FunctionCellular PhysiologyCellular ProcessClinicalComplexCustomCytoplasmic GranulesDevelopmentDiseaseDisorderDysfunctionEnvironmentEvaluationEyeEyeballFLIM imagingFluorescenceFunctional ImagingFunctional disorderFutureGoalsHealthHumanIllinoisImaging DeviceImaging InstrumentImaging ToolImaging technologyIntracellular Communication and SignalingIntramural ProgramIntramural Research ProgramInvestigationKnowledgeLeadLightLipofuscinMapsMelaninsMelanosomesMentorsMicroscopicMicroscopyModern ManModificationMonitorNational Eye InstituteNeural RetinaOphthalmologyOphthalmoscopyOptical InstrumentOptics/Optical InstrumentOrigin of LifeOuter pigmented layer of retinaPb elementPhasePhotoradiationPhysiologic ImagingPhysiopathologyPigment EpitheliumPigment cell layer of retinaPigmented layer of retinaPigmentsPlayPreparationProcessPropertyReportingResearchResolutionRetinaRetina ProperRetinal DiseasesRetinal DisorderRetinal Pigment EpitheliumRetinal PigmentsRetinal pigment epithelial cellsRoleSchemeSensitivity and SpecificitySightSignal TransductionSignal Transduction SystemsSignalingStratificationStructure of retinal pigment epitheliumSubcellular ProcessTherapeuticTissuesTrainingTranslationsUniversitiesVisionVisual PigmentsWorkadaptive opticsage associatedage correlatedage dependentage dependent macular degenerationage induced macular degenerationage linkedage relatedage related macular diseaseage related macular dystrophyage specificagesaging processbiological signal transductioncareercareer developmentcustomscytotoxicdevelopmentalexperienceexposure to lightexposure to visible lightfluorescence life-time imagingfluorescence life-time imaging microscopyfluorescence lifetime imagingfluorescence lifetime imaging microscopyfluorophorefunctional statusgranuleheavy metal Pbheavy metal leadimage translationimaging approachimaging based approachimaging in vivoin vivoin vivo imaginginsightlight exposurelight pollution exposuremosaicmulti-modalitymultidisciplinarymultimodalitypathophysiologyphotoprotectionphotoprotectivephysiological imagingpigmentpostmitoticpreparationsprogramsresolutionsretina diseaseretina disorderretina photosensitive pigmentretinal imagingretinopathysenile macular diseasesocial roletranslationvisual cyclevisual function
Description preview
Project Summary/Abstract
Intracellular melanin and lipofuscin granules represent two distinct classes of photopigments found in cells
of the retinal pigment epithelium (RPE). With increasing age, clinically observable decreases in RPE melanin
and accumulation of RPE lipofuscin granules are typical, and specific interactions between these pigments…
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