grant
Assessing the Strength of Weak Ties
Organization SOUTH DAKOTA STATE UNIVERSITYLocation BROOKINGS, UNITED STATESPosted 20 Sept 2019Deadline 31 Jul 2028
NIHUS FederalResearch GrantFY2025AddressAssayBehaviorBioassayBioinformaticsBiologic SciencesBiological AssayBiological SciencesBiologyBiophysicsBioscienceCell Communication and SignalingCell SignalingChemistryChromatinComplexComprehensionComputational toolkitDNADNA mutationData AnalysesData AnalysisDeoxyribonucleic AcidDiseaseDisorderElectrostaticsElementsEnvironmentFoundationsGeneticGenetic ChangeGenetic defectGenetic mutationGerm LinesGoalsH-bondHealthHumanHydrogen BondingHydrophobicityInstitutionInterdisciplinary ResearchInterdisciplinary StudyInternetInterventionIntracellular Communication and SignalingInvestigationKnowledgeLengthLife SciencesLinkLipid BilayersMacromolecular StructureMissionModelingModern ManMolecular ProbesMolecular StructureMultidisciplinary CollaborationMultidisciplinary ResearchMutationNamesNational Institutes of HealthNatureNon-Polyadenylated RNAOncogenicOrganismPhasePhysicsPlayPost-Translational Modification Protein/Amino Acid BiochemistryPost-Translational ModificationsPost-Translational Protein ModificationPost-Translational Protein ProcessingPosttranslational ModificationsPosttranslational Protein ProcessingPreventative interventionProtein ModificationProteinsProteomeProteomicsPublic HealthRNARNA Gene ProductsRationalizationReagentResearchResearch MethodologyResearch MethodsRibonucleic AcidRoleScienceServicesSignal TransductionSignal Transduction SystemsSignalingStructureSystemTestingTherapeutic InterventionUnited States National Institutes of HealthWWWbiological signal transductionbiophysical chemistrybiophysical foundationbiophysical principlesbiophysical sciencescareercomputational toolboxcomputational toolscomputational toolsetcomputerized toolsdata interpretationdeep learningdeep learning methoddeep learning strategydesigndesigningdisease causing variantdisease-causing alleledisease-causing mutationexperimentexperimental researchexperimental studyexperimentsgenome mutationinnovateinnovationinnovativeinsightinsoluble aggregateintervention for preventionintervention therapylipid bilayer membraneliving systemmacromoleculemutantnamenamednamingnovelpathogenic allelepathogenic variantpreventpreventingprevention interventionpreventional intervention strategypreventive interventionprotein aggregateprotein aggregationprotein foldingprotein functionprotein protein interactionprotein structureprotein structuresproteins structurerapid assayrapid testrapid testsresearch and methodssmall moleculesocial rolestudent trainingtoolundergradundergraduateundergraduate studentvan der Waals forcewebweb servicesweb-based serviceworld wide web
Description preview
Even though the paradigm shift in structure biology, heralded by AlphaFold2 of the deep-learning era, has
transformed biological sciences, the true physics of the protein folding problem remains unresolved. For
example, predicting the effects of mutations on protein stability remains an outstanding challenge, even though
structure prediction is…
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