grant
Assessing the Effects of Plastics on Intestinal Health: A Comparative Study using 3D Human and Mouse Intestinal Models
Organization TUFTS UNIVERSITY MEDFORDLocation Boston, UNITED STATESPosted 12 Jun 2025Deadline 31 Mar 2030
NIHUS FederalResearch GrantFY20253-D3-Dimensional3DActive OxygenAcuteAddressAffectAlimentary CanalAnimal ModelAnimal Models and Related StudiesAnimalsAntigensApoptosisApoptosis PathwayApoptoticAromatic Polycyclic HydrocarbonsAutomobile DrivingBenchmarkingBest Practice AnalysisBiologicalBiomedical EngineeringBloodBlood Reticuloendothelial SystemBody TissuesCell BodyCell Culture TechniquesCellsCelluloseCharacteristicsChronicClinicalComparative StudyComplexData SetDigestive TractDimensionsDiseaseDisorderDoseEcologic SystemsEcological SystemsEcosystemEndocytosisEndotoxinsEnsureEnvironmentEpidemiological dataEpidemiology dataEpithelial CellsEpitheliumEquilibriumExposure toFecesFood ChainFutureGI TractGastrointestinal DiseasesGastrointestinal TractGastrointestinal tract structureHealthHumanImmuneImmune reactionImmune responseImmunesImmunomodulationIn VitroIndividualInfiltrationInflammationInflammatoryInflammatory Bowel DiseasesInflammatory Bowel DisorderInflammatory ResponseIntestinalIntestinal DiseasesIntestinal DisorderIntestinesLinkLipopolysaccharidesM cellMacrophageMediatingMiceMice MammalsModelingModern ManMolecularMonitorMurineMusMφNerve CellsNerve UnitNeural CellNeurocyteNeurologicNeurologicalNeuronsOrganOrganoidsOutcomeOxidative StressOxygen RadicalsParticle SizePatientsPlasticsPlayPollutionPolyanhydroglucuronic AcidPolystyrenesPolystyrolPredictive ValuePrevalencePro-OxidantsProgrammed Cell DeathPropertyReactionReactive Oxygen SpeciesResearchRoleShapesSiteSourceTestingTimeTissue ModelTissuesTranslatingUV irradiatedUV irradiationUrineVariantVariationWhole Organismalimentary tractalpha-Cellulosebalancebalance functionbenchmarkbio-engineeredbio-engineersbioengineeringbiologicbiological engineeringbowelbowel inflammationcell culturecell culturescomparativecontamination in food chaincytokinedigestive canaldisease modeldisorder modeldrivingepidemiologic dataexperimentexperimental researchexperimental studyexperimentsfood chain contaminationgastrointestinal disordergut healthgut homeostasisgut inflammationhost responsehuman datahuman modelimmune modulationimmune regulationimmune system responseimmunogenimmunologic reactivity controlimmunomodulatoryimmunoreactionimmunoregulationimmunoregulatoryimmunoresponsein vivoinflamed bowelinflamed gutinflamed intestineinflammation markerinflammatory disease of the intestineinflammatory disorder of the intestineinflammatory markerinhibitorinsightintestinal autoinflammationintestinal barrierintestinal inflammationintestinal mucosal barrierintestine diseaseintestine disordermicrobialmicrobial consortiamicrobial floramicrobiotamicrofloramodel of animalmodel of humanmonolayermouse modelmultispecies consortiamurine modelnano particlenano-sized particlenanoparticlenanosized particleneuronalparticlepolyaromatic hydrocarbonspolynuclear aromatic hydrocarbonresponsesocial rolespecies differencestoolthree dimensionalultra violet irradiationultraviolet irradiation
Description preview
Project Summary/Abstract
The escalating presence of microplastics (MPs) and nanoplastics (NPs) in the environment raises alarms about
their potential impact on both ecological systems and human health. Notably, these particles are often found in
the human gastrointestinal tract, yet a comprehensive understanding of their health effects remains…
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