grant
ARID1 proteins orchestrate cranial neural crest differentiation
Organization CINCINNATI CHILDRENS HOSP MED CTRLocation CINCINNATI, UNITED STATESPosted 16 Jun 2025Deadline 31 Mar 2030
NIHUS FederalResearch GrantFY2025ARID1AARID1A geneAT- rich interactive domain-containing protein 1AAT-rich interactive domain 1A geneAnimal ModelAnimal Models and Related StudiesBasal Transcription FactorBasal transcription factor genesBindingBinding SitesCRISPR interferenceCRISPR-dCas9-mediated repressionCRISPR/dCas9 interferenceCRISPR/dCas9-mediated transcriptional inhibitionCRISPRiCartilageCartilaginous TissueCell Communication and SignalingCell DifferentiationCell Differentiation processCell LineCell Migration AssayCell SignalingCellLineCephalicChromatinClustered Regularly Interspaced Short Palindromic Repeats interferenceCoffin-Siris SyndromeCombining SiteComplexCranialCraniofacial AbnormalitiesDNA Polymerase IIDNA Polymerase epsilonDNA mutationDNA-Dependent DNA Polymerase IIDNA-Dependent RNA Polymerase IIDataDefectDevelopmentDiseaseDisorderEmbryoEmbryonicEnhancersEnsureEpithelial CellsEpitheliumErinaceidaeGLI-Kruppel Family Member 3GLI3GLI3 geneGene Down-RegulationGene TranscriptionGeneral Transcription Factor GeneGeneral Transcription FactorsGenesGenetic ChangeGenetic TranscriptionGenetic defectGenetic mutationGenomicsGliaGlial CellsHedgehog (Hh) signal transduction pathwayHedgehogsIn VitroIntellectual disabilityIntellectual functioning disabilityIntellectual limitationIntracellular Communication and SignalingKolliker's reticulumLeadLinkMaintenanceMediatingMesenchymalMiceMice MammalsMigration AssayModalityMolecularMolecular InteractionMurineMusMutationNerve CellsNerve UnitNeural CellNeural CrestNeural Crest CellNeurocyteNeuroectodermNeurogliaNeuroglial CellsNeuronsNeurosphereNon-Polyadenylated RNANon-neuronal cellNonneuronal cellOncogene GLI3PAP-APathogenicityPathway interactionsPatientsPb elementPhenotypePlayPol IIPopulationProcessPromoter RegionsPromotor RegionsPropertyProteinsProteomicsRNARNA ExpressionRNA Gene ProductsRNA Polymerase BRNA Polymerase IIReactive SiteRegulationRepressionRibonucleic AcidRoleSignal PathwaySignal TransductionSignal Transduction PathwaySignal Transduction SystemsSignalingSpecific qualifier valueSpecifiedStrains Cell LinesTestingTranscriptionTranscription ActivationTranscription Factor Proto-OncogeneTranscription RepressionTranscription factor genesTranscriptional ActivationTranscriptional ControlTranscriptional RegulationVariantVariationWNT Signaling PathwayWNT signalingWorkbiological signal transductionbonecellular differentiationchromatin remodelingcraniofacialcraniofacial anomaliescraniofacial defectscraniofacial developmentcraniofacial malformationcraniofaciescultured cell linedevelopmentaldwarfism-onychodysplasia syndromefifth digit syndromegene inductiongene regulatory networkgene repressiongenetic promoter elementgenetic promoter sequencegenome mutationheavy metal Pbheavy metal leadhedgehog signalinghedgehog signaling pathwayhh signaling pathwayiPSiPSCiPSCsin vivoinduced pluripotent cellinduced pluripotent stem cellinducible pluripotent cellinducible pluripotent stem cellinduction of genesintellectual and developmental disabilitylimited intellectual functioningmembermigrationmigratory populationmodel of animalmosaicmouse modelmultipotencymultipotentmurine modelnerve cementneuronalnovelpathwaypluripotencypluripotency factorpluripotent statepreventpreventingpromoter sequenceprotein complexrepressing CRISPR-dCas9 systemskeletalsmoothened signaling pathwaysocial roletranscription factor
Description preview
Project Summary (Abstract)
Cranial neural crest cells (CNCCs) are a unique, multipotent, migratory population that give rise to both
ectodermal/non-ectomesenchymal (neurons, glia) and mesodermal/ectomesenchymal (bone,
cartilage) derivatives. The cellular and molecular mechanisms that allow for proper craniofacial
development, including…
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