grant
ARFs, ORPs and the control of cell migration
Organization UNIVERSITY OF VIRGINIALocation CHARLOTTESVILLE, UNITED STATESPosted 1 Jan 2024Deadline 31 Dec 2028
NIHUS FederalResearch GrantFY2025ADP-Ribosylation FactorsAMPA ReceptorsARF Protein CofactorActinsAdhesion PlaquesAdhesionsAttentionAutomobile DrivingCalciumCalcium ChannelCalcium Channel Antagonist ReceptorCalcium Channel Blocker ReceptorsCalcium Ion ChannelsCalcium Ion SignalingCalcium SignalingCell BodyCell FunctionCell LocomotionCell MigrationCell MovementCell PhysiologyCell ProcessCell membraneCell-Matrix Adherens JunctionsCellsCellular FunctionCellular MatrixCellular MigrationCellular MotilityCellular PhysiologyCellular ProcessCholine GlycerophospholipidsCholine PhosphoglyceridesComplexCytoplasmic MembraneCytoskeletal SystemCytoskeletonDNA mutationDataEmbryo DevelopmentEmbryogenesisEmbryonic DevelopmentEndocytosisEndoplasmic ReticulumErgastoplasmFailureFamilyFocal AdhesionsFocal ContactsGTP PhosphohydrolasesGTPasesGenetic ChangeGenetic defectGenetic mutationGliaGlial CellsGoalsGuanosine Triphosphate PhosphohydrolasesGuanosinetriphosphatasesHumanInflammationInositide PhospholipidsInositol PhosphoglyceridesInositol PhospholipidsIntegrinsIntegrins Extracellular MatrixIsoformsKolliker's reticulumLecithinLipidsMembraneMetastasisMetastasizeMetastatic LesionMetastatic MassMetastatic NeoplasmMetastatic TumorMicro-tubuleMicrotubulesModern ManMolecularMutationNeoplasm MetastasisNeurogliaNeuroglial CellsNon-neuronal cellNonneuronal cellPatientsPhosphatidyl InositolPhosphatidylcholinesPhosphatidylinositolsPhosphoinositidesPhysiologicPhysiologicalPlasma MembraneProcessProtein IsoformsProteinsPtdInsPublishingReportingRoleSecondary NeoplasmSecondary TumorSiteSubcellular ProcessVDCCVesicleVoltage-Dependent Calcium ChannelsWound RepairX-Linked Mental RetardationX-Linked Mental Retardation DisordersX-Linked Mental Retardation SyndromesX-linked intellectual disabilitycancer metastasiscell motilitydrivingexcitatory neurongenome mutationguanosinetriphosphataseintracellular skeletonlipid exchange proteinlipid transfer proteinmembermembrane structuremigrationnerve cementnovelplasmalemmapostsynapticprotein functionresponserhosocial roletraffickingtumortumor cell metastasiswound healingwound recoverywound resolution
Description preview
The ADP-ribosylation factors (ARFs) are a family of six small, Ras-like GTPases best known for
their roles in membrane trafficking, where they control the formation of carrier vesicles at
multiple intracellular sites. Over the years, we have defined roles for ARFs and their regulators
(GEF and GAPs) in multiple cellular processes including…
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