grant
ARDVARC-Advancing Rare Disorders: Vascular mAlformation Research Network with CaNVAS
Organization CHILDREN'S HOSP OF PHILADELPHIALocation PHILADELPHIA, UNITED STATESPosted 25 Aug 2025Deadline 31 May 2030
NIHUS FederalResearch GrantFY20250-11 years oldAcademic Medical CentersAddressAreaArteriovenous AngiomaArteriovenous HemangiomaArteriovenous malformationAwarenessBiological MarkersBleedingBloodBlood Reticuloendothelial SystemBlood VesselsBody TissuesCare GiversCareer MobilityCaregiversCategoriesCephalicChildChild YouthChildren (0-21)ClinicalClinical ResearchClinical StudyClinical TrialsCollaborationsCollectionComplexConfusionConfusional StateCranialDataDevelopmentDiagnosisDiseaseDisease ProgressionDisorderDrug TherapyEvaluation StudiesFacultyFamilyFosteringFutureGeneral RadiologyGeneralized GrowthGenotypeGoalsGrantGrowthHealth ServicesHemorrhageInfrastructureInterdisciplinary ResearchInterdisciplinary StudyInterventionInvestigationInvestigatorsLeadLiquid substanceLong-Term EffectsLymphLymphatic AbnormalitiesLymphatic anomaliesLymphatic defectsMeasurementMedicalMental ConfusionMorbidityMorbidity - disease rateMultidisciplinary CollaborationMultidisciplinary ResearchNatural HistoryOrganOrphan DiseaseOutcomeOutcome MeasurePI3K-AlphaPIK3-AlphaPIK3CAPIK3CA genePainPainfulPathway interactionsPatient Outcomes AssessmentsPatient Reported MeasuresPatient Reported OutcomesPatient outcomePatient-Centered OutcomesPatient-Focused OutcomesPatientsPb elementPediatric HematologistPediatric OncologistPharmacological TreatmentPharmacotherapyPhenotypePhosphatidylinositol 3-Kinase, Catalytic, 110-kD, AlphaPhosphatidylinositol 3-Kinase, Catalytic, AlphaPilot ProjectsPopulationProcessProliferatingRacemose AngiomaRacemose HemangiomaRadiologyRadiology SpecialtyRare DiseasesRare DisorderRegistriesResearchResearch PersonnelResearch ResourcesResearchersResourcesSamplingScienceScientistSiteSomatic MutationSpecialtyStructureTimeTissue GrowthTissuesTraining ProgramsUniversity Medical CentersVascular DiseasesVascular DisorderWorkbio-markersbiobankbiologic markerbiomarkerbiorepositoryblood lossblood vessel disordercareercareer advancementcareer developmentcareer transitioncell free DNAcell free circulating DNAclinical careclinical infrastructureclinical outcome measuresclinical trial readinesscohortdesigndesigningdevelopmentaldisease phenotypedrug interventiondrug treatmenteffective therapyeffective treatmentfluidhealth related quality of lifeheavy metal Pbheavy metal leadimprovedimproved outcomeinnovateinnovationinnovativeinterestintervention effectkidsliquidlymph channellymph vessellymphatic channellymphatic fluidlymphatic malformationslymphatic vesselmalformationmeasurable outcomemedical specialtiesmembermortalitynew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovelnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapyontogenyoperationoperationsorphan disorderoutcome measurementp110-Alphapathwaypatient advocacy grouppatient oriented outcomespharmaceutical interventionpharmacological interventionpharmacological therapypharmacology interventionpharmacology treatmentpharmacotherapeuticspilot studyprogramsprospectiveresponse to therapyresponse to treatmentsomatic varianttherapeutic responsetherapy responsetreatment responsetreatment responsivenessvascularvascular dysfunctionvasculopathyyoungster
Description preview
Vascular malformations (VMs) result from abnormal overgrowth of blood and lymphatic vessels that are commonly driven by somatic variants in growth and proliferation pathways. Complex VMs are destructive, proliferative disorders with high morbidity and mortality. VMs are incurable and limited treatments exist. Advancing Rare Disorders-Vascular…
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