grant
Architecture and function of condensates formed by ubiquitin-binding shuttle proteins and protein quality control components
Organization SYRACUSE UNIVERSITYLocation SYRACUSE, UNITED STATESPosted 1 Jun 2025Deadline 31 May 2030
NIHUS FederalResearch GrantFY202520S Catalytic Proteasome20S Core Proteasome20S Proteasome20S ProteosomeAPF-1ATP-Dependent Proteolysis Factor 1Amyotrophic Lateral SclerosisAmyotrophic Lateral Sclerosis Motor Neuron DiseaseAmyotrophic lateral sclerosis and frontotemporal degenerationAmyotrophic lateral sclerosis and frontotemporal dementiaArchitectureAutomobile DrivingAutophagocytosisBehaviorBindingBiophysicsCell BodyCell FunctionCell PhysiologyCell ProcessCellsCellular FunctionCellular PhysiologyCellular ProcessCellular StressCellular Stress ResponseCellular biologyCharacteristicsDataDegenerative Neurologic DisordersDeubiquitinationDevelopmentDiseaseDisorderEngineering / ArchitectureFTD/ALSFTLD/ALSFrontotemporal Lobar Degeneration/Amyotrophic lateral sclerosisGehrig's DiseaseHMG-20Heat shock proteinsHigh Mobility Protein 20Immune systemIn VitroLengthLigaseLigase GeneLinkLiquid substanceLou Gehrig DiseaseMacropainMacroxyproteinaseMediatingMembraneMetabolic Protein DegradationMolecularMolecular InteractionMulticatalytic ProteinaseNervous System Degenerative DiseasesNeural Degenerative DiseasesNeural degenerative DisordersNeurodegenerative DiseasesNeurodegenerative DisordersNeurologic Degenerative ConditionsOrganism-Level ProcessOrganismal ProcessOutcomePathway interactionsPhasePhysical condensationPhysiologicPhysiologic ProcessesPhysiologicalPhysiological ProcessesProsomeProteasomeProteasome Endopeptidase ComplexProtein TurnoverProteinsProteosomeQuality ControlRegulatory Protein DegradationResearchRoleStressStructureSubcellular ProcessSynthetasesTimeUbiquitilationUbiquitinUbiquitinationUbiquitinoylationWorkamyotrophic lateral sclerosis with frontotemporal dementiaamyotrophic lateral sclerosis/FTLDamyotrophic lateral sclerosis/frontotemporal dementiaamyotrophic lateral sclerosis/ftdautophagybiological adaptation to stressbiophysical foundationbiophysical principlesbiophysical sciencescell biologycell stresscondensationde-ubiquitinasede-ubiquitinating enzymedegenerative diseases of motor and sensory neuronsdegenerative neurological diseasesdevelopmentaldrivingexperimentexperimental researchexperimental studyexperimentsfluidfrontotemporal dementia-amyotrophic lateral sclerosisfrontotemporal lobar dementia amyotrophic lateral sclerosisfunctional outcomesliquidmembrane structuremulticatalytic endopeptidase complexneurodegenerative illnessnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapypathwayprogramsprotein degradationprotein homeostasisproteostasisreaction; crisisreconstitutereconstitutionsocial rolestemstress proteinstress responsestress; reactionubiquinationubiquitin conjugationubiquitin isopeptidaseubiquitin-specific isopeptidase
Description preview
PROJECT SUMMARY/ABSTRACT: Efficient and effective protein quality control (PQC) is essential to
proper cell function. Despite extensive research, mechanisms underlying PQC remain incompletely
understood. Consequently, development of new therapies to treat conditions with dysregulated PQC
such as proteinopathies and neurodegenerative disorders is…
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