grant

Archaea as a microbial model for developmental mechanoplasticity

Organization TRUSTEES OF INDIANA UNIVERSITYLocation BLOOMINGTON, UNITED STATESPosted 1 Jan 2025Deadline 31 Dec 2029
NIHUS FederalResearch GrantFY2026AddressAnimalsArchaeaArchaebacteriaArchaeobacteriaArchaeonBehaviorBiochemicalBiologic ModelsBiologicalBiological ModelsBiomechanicsBiophysical ProcessBiophysicsBody FluidsCRISPR interferenceCRISPR-dCas9-mediated repressionCRISPR/dCas9 interferenceCRISPR/dCas9-mediated transcriptional inhibitionCRISPRiCell BodyCell FunctionCell PhysiologyCell ProcessCell WallCellsCellular FunctionCellular MatrixCellular PhysiologyCellular ProcessCellular biologyClustered Regularly Interspaced Short Palindromic Repeats interferenceCrowdingCytoskeletal SystemCytoskeletonDataDevelopmentDiseaseDisorderEnvironmentExpression SignatureFutureGene Expression ProfileGenomeGlycoproteinsHaloferax volcaniiHealthHumanHuman MicrobiomeImageImmune GlobulinsImmunoglobulinsIn VitroLaboratoriesLibrariesLightMammalian CellMechanical StressMechanicsMicrobeMicrobiomicsMicrofluidic DeviceMicrofluidic Lab-On-A-ChipMicrofluidic MicrochipsMicrofluidicsModel SystemModelingModern ManMolecularMolecular ProbesOutcomePathway interactionsPhotoradiationPhysiologicPhysiologicalPhysiologyPlayPolymersPopulationProteinsResearchRoleSightSubcellular ProcessTechnical ExpertiseTranslatingVisionanimal tissuebiologicbiomechanicalbiophysical foundationbiophysical mechanismbiophysical principlesbiophysical sciencescandidate identificationcell biologydevelopmentalentire genomefull genomegene expression patterngene expression signaturegut healthhuman-associated microbiomeimagingin vivoinsightintracellular skeletonlive cell imagelive cell imaginglive cellular imagelive cellular imagingmechanicmechanicalmechanical cuemechanical forcemechanical signalmicrobialmicrobiomemicrobiome researchmicrobiome sciencemicrobiome studiesmicrofluidic chippathwaypolymerpolymericpressureprogramsreconstitutereconstitutionrepressing CRISPR-dCas9 systemresponsereverse geneticssocial rolespatial and temporalspatial temporalspatiotemporaltechnical skillstranscriptional profiletranscriptional signaturevisual functionwhole genomeµfluidic
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PROJECT SUMMARY
Cells with identical genomes can follow different developmental paths depending on their mechanical

interactions with the environment. Archaea impact human health by playing critical roles in environmental cycles

and animal microbiomes. Yet little is known about their cell biology. In contrast to most microbes, archaea are

as…

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Archaea as a microbial model for developmental mechanoplasticity — TRUSTEES OF INDIANA UNIVERSITY | UNITED STATES | Jan | Dev Procure