grant
Applying digital phenotypes and epigenetics to understand clinical outcomes in acute hypoxemic respiratory failure without acute respiratory distress syndrome (NAHRF)
Organization UNIVERSITY OF CALIFORNIA AT DAVISLocation DAVIS, UNITED STATESPosted 1 Aug 2025Deadline 31 Jul 2030
NIHUS FederalResearch GrantFY202521+ years oldARDSAccident and Emergency departmentActive LearningAcute Respiratory DistressAcute Respiratory Distress SyndromeAdultAdult ARDSAdult HumanAdult RDSAdult Respiratory Distress SyndromeAffectAutomobile DrivingBioinformaticsBiologicalBiological MarkersBiologyClassificationClinicalClinical DataClinical InvestigatorClinical ResearchClinical StudyClinical TrialsCollaborationsCooperative LearningCritical CareCritical IllnessCritically IllDNADNA MethylationDa Nang LungDataDeath RateDeoxyribonucleic AcidDerivationDerivation procedureDeteriorationDevelopmentDevelopment PlansDiagnosisDiagnosticDisease ProgressionDrug TherapyED careER careEligibilityEligibility DeterminationEmergency CareEmergency DepartmentEmergency Department careEmergency Room careEmergency care researchEmergency health careEmergency medical careEmergency researchEmergency roomEnrollmentEnvironmentEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessExperiential LearningFailureFutureGoalsHeterogeneityHospitalsInflammatoryInternationalInvestigationKnowledgeLeadershipLearningMachine LearningMechanical ventilationMentorsMentorshipMethodologyMethodsMethylationMissionModelingModificationMorbidityMorbidity - disease rateMulti-center studiesMulticenter StudiesNHLBINational Heart, Lung, and Blood InstituteOnset of illnessOutcomePatient CarePatient Care DeliveryPatientsPerformancePersonalized medical approachPharmacological TreatmentPharmacotherapyPhenotypePopulationProbabilistic ModelsProbability ModelsPrognosisProtocol ScreeningPublic HealthRecordsResearchResearch ResourcesResearch SupportResourcesScientistSeveritiesSeverity of illnessShock LungStatistical MethodsStatistical ModelsStiff lungSyndromeSystematicsTechniquesTherapeuticTrainingTranslational ResearchTranslational ScienceUnited StatesValidationacute careacute hypoxemic respiratory failureacute hypoxic respiratory failureacute onset hypoxemic respiratory failureadulthoodapplied learningbio-markersbiologicbiologic markerbiological heterogeneitybiomarkerbiomarker discoverycare for patientscare of patientscareer developmentcaring for patientsclinical decision supportclinical heterogeneityclinical predictive modelcytokinedesigndesigningdevelopmentaldigital phenotypingdisease onsetdisease severitydisorder onsetdrivingdrug interventiondrug treatmenteffective therapyeffective treatmentenrollepigenetic biomarkerepigenetic markerepigeneticallyepigenomeexperiencehands-on learninghealth datahuman diseaseimprovedimproved outcomeindividualized approachinnovateinnovationinnovativeinteractive engagementinteractive learningmachine based learningmachine learning based modelmachine learning modelmechanical respiratory assistmechanically ventilatedmethylomemortalitymortality ratemortality ratiomultidisciplinarynew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic targetnew therapy targetnovelnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel therapeutic targetnovel therapy targetpatient oriented researchpatient oriented studypatient subclasspatient subclusterpatient subgroupspatient subpopulationspatient subsetspatient subtypespatient variabilitypatient variationpersonalized approachpharmaceutical interventionpharmacological interventionpharmacological therapypharmacology interventionpharmacology treatmentpharmacotherapeuticsprecision approachpreventpreventingprospectiverespiratoryrespiratory distress syndromeresponse to therapyresponse to treatmentrisk stratificationscreeningscreeningsskillsstatistic methodsstatistical linear mixed modelsstatistical linear modelsstatisticsstratify risksuccesstailored approachtargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttherapeutic responsetherapy optimizationtherapy responsetooltranslation researchtranslational investigationtreatment optimizationtreatment responsetreatment responsivenessvalidationsvariability between patientsvariation between patientswet lung
Description preview
PROJECT SUMMARY
Each year approximately 1 million adults receive invasive mechanical ventilation in the United States for acute
hypoxemic respiratory failure (AHRF), and 30-40% of these patients die in the hospital. Most research has
focused on acute respiratory distress syndrome (ARDS), a severe form of AHRF that affects one quarter of…
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