grant
Antistaphylococcal Phage Enhancement by Restriction Bypass and Dynamic Imaging
Organization WAYNE STATE UNIVERSITYLocation DETROIT, UNITED STATESPosted 5 May 2026Deadline 30 Apr 2028
NIHUS FederalResearch GrantFY2026AddressAdoptionAdvanced DevelopmentAntibiotic AgentsAntibiotic DrugsAntibiotic ResistanceAntibioticsBacteriaBacteria resistanceBacteria resistantBacterial resistantBacteriophagesBiologicalBody TissuesBypassCapsidCapsid ProteinsCementationCessation of lifeChimera ProteinChimeric ProteinsClinicalClinical TrialsCoat ProteinsCombined Modality TherapyComplexConfocal MicroscopyCustomDNADNA Restriction-Modification EnzymesDNA mutationDaptomycinDaughterDeathDeoxyribonucleic AcidDetectable Residual DiseaseDevelopmentDoseDrug KineticsEC 2.1.1EffectivenessElectroporationEnzyme GeneEnzymesFrequenciesFusion ProteinGenerationsGenetic ChangeGenetic defectGenetic mutationGenomeGenomic DNAGoalsHealth Care CostsHealth CostsHost DefenseImageIn SituIn VitroIndividualInfectionInfiltrationInterventionInvestigatorsLabelLife CycleLife Cycle StagesLyticMDR organismMDR pathogenMethodsMethylationMethyltransferaseMicrobeMinimal Residual DiseaseMiscellaneous AntibioticModificationMonitorMorbidityMulti-Drug ResistanceMultidrug ResistanceMultimodal TherapyMultimodal TreatmentMultiple Drug ResistanceMultiple Drug ResistantMutationPK/PDPenetrationPhagesPharmacodynamicsPharmacokineticsPredispositionProteinsRecombinantsResearch PersonnelResearchersResidual NeoplasmResidual TumorsResistanceResistance to Multi-drugResistance to MultidrugResistance to Multiple DrugResistance to antibioticsResistant to Multiple DrugResistant to antibioticsResistant to multi-drugResistant to multidrugRestriction-Modification SystemsS aureusS. aureusS. aureus infectionSalvage TherapySalvage-TxSpecificityStaph aureusStaph aureus infectionStaphylococcal BacteriophagesStaphylococcal InfectionsStaphylococcal PhagesStaphylococcus PhagesStaphylococcus aureusStaphylococcus aureus infectionStaphylococcus infectionStructureSusceptibilitySystemTechniquesTechnologyTestingTherapeuticTherapeutic StudiesTherapy ResearchTimeTissuesUnited StatesVancomycinViral Coat ProteinsViral Outer Coat ProteinVisualizationWorkantibiotic drug resistanceantibiotic resistantassess effectivenessbacterial resistancebacterial virusbiologiccombatcombination therapycombined modality treatmentcombined treatmentcustomsdetermine effectivenessdevelopmentaleffectiveness assessmenteffectiveness evaluationelectroporative deliveryendolysinevaluate effectivenessexamine effectivenessfluorophoregDNAgene electrotransfergenome mutationhuman pathogenhuman subjectimagingimprovedinfected with S. aureusinfected with Staph aureusinfected with Staphylococcus aureuslambda-endolysinlife coursemethylasemethylation patternmortalitymulti-drug resistantmulti-drug resistant organismmulti-drug resistant pathogenmulti-modal therapymulti-modal treatmentmultidisciplinarymultidrug resistantmultidrug resistant organismmultidrug resistant pathogenmultiple drug resistant organismmultiple drug resistant pathogennew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachparticlepharmacokinetics and pharmacodynamicspre-clinicalpreclinicalreceptor bindingreceptor boundresidual diseaseresistance to Bacteriaresistance to Bacterialresistantresistant to Bacteriaresistant to Bacterialstaph infectionssynergismtooltransmethylaseuptake
Description preview
Project Summary/Abstract
Staphylococcus aureus is the most common invasive human pathogen and a major contributor to
infection-related morbidity and mortality. Antibiotic resistance is often prevalent at baseline and can develop on
therapy. Further compounding the clinical challenge, even susceptible bacteria fail to respond appropriately to…
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