grant
ANTIBODY REAGENTS FOR IMMUNOLOGIC ANALYSIS OF UNDER-REPRESENTED MAMMALIAN MODELS
Organization INTEGRAL MOLECULARLocation PHILADELPHIA, UNITED STATESPosted 1 Jun 2025Deadline 31 May 2028
NIHUS FederalResearch GrantFY2025AffinityAnimal ModelAnimal Models and Related StudiesAnimalsAntibodiesAntigenic DeterminantsAntigensBacteriophagesBindingBinding DeterminantsBiomedical ResearchBiosensorCallithrixCell BodyCellsChickensCross ReactionsEnsureEpitopesFerretsFlow CytofluorometriesFlow CytofluorometryFlow CytometryFlow MicrofluorimetryFlow MicrofluorometryGallus domesticusGallus gallusGallus gallus domesticusHapaleHumanImmuneImmune TargetingImmunesImmunizeImmunoblottingImmunochemical ImmunologicImmunofluorescenceImmunofluorescence ImmunologicImmunologicImmunologicalImmunologicallyImmunologicsMarmosetsMembraneMembrane Protein GeneMembrane ProteinsMembrane-Associated ProteinsMessenger RNAMiceMice MammalsMiniature SwineMinipigsModelingModern ManMolecular ConfigurationMolecular ConformationMolecular InteractionMolecular StereochemistryMurineMusPhagesPhaseProcessProteinsProteomeRNA immunizationRNA vaccinationReagentRecombinantsReproducibilityResearchShort-Tusked MarmosetSpecificitySurface ProteinsTestingTreesWestern BlottingWestern Immunoblottingbacterial virusbiological sensorcommercializationconformationconformationalconformational stateconformationallyconformationsdesigndesigningexperimentexperimental researchexperimental studyexperimentsflow cytophotometryimmunocytochemistryimmunogenmRNAmRNA immunizationmRNA vaccinationmembrane structuremini pigmini-swineminiswinemodel of animalprotein blotting
Description preview
In proof-of-concept research during our Phase 1 project, we chose 10 important immune targets to discover MAbs. Our strategy was to select for pan-reactive MAbs that bind to conserved mammalian epitopes among three diverse species that span the mammalian tree (marmoset, minipig, and ferret). Our results demonstrate that we were able to generate…
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