grant
Antiarrhythmic mechanisms of chronic vagal nerve stimulation in sympathetic neurons
Organization UNIVERSITY OF CALIFORNIA LOS ANGELESLocation LOS ANGELES, UNITED STATESPosted 10 Aug 2023Deadline 31 Jul 2028
NIHUS FederalResearch GrantFY2025Action PotentialsAcuteAdrenergic AntagonistsAdrenergic BlockadersAdrenergic BlockersAdrenergic Receptor AntagonistsAdrenergic Receptor BlockadersAdrenergic-Blocking AgentsAdrenolytic AgentsAdrenolytic DrugsAdrenolyticsAnimal ModelAnimal Models and Related StudiesAnimalsAnti-AdrenergicsAnti-Arrhythmia AgentsAnti-Arrhythmia DrugsAnti-ArrhythmicsAnti-adrenergic AgentsAntiadrenergic AgentsAntiadrenergicsAntiinflammatory EffectAttenuatedCardiacCardiac infarctionCardiomyopathiesCause of DeathCell BodyCell CommunicationCell Communication and SignalingCell InteractionCell SignalingCell-to-Cell InteractionCellsCervicothoracic GanglionChronicClinical TrialsComplexComputational toolkitCoronaryDataDoseDrug TherapyDrugsDysfunctionElectrophysiologyElectrophysiology (science)ElementsEquilibriumFamily suidaeFunctional disorderGoalsHeartHeart InjuriesHeterogeneityHumanImmuneImmune infiltratesImmunesInfarctionInflammationInflammatoryInterventionIntracellular Communication and SignalingInvestigationInvestigatorsLifeLinkMediatingMedicationModern ManMyocardialMyocardial DiseasesMyocardial DisorderMyocardial InfarctMyocardial InfarctionMyocardial depressionMyocardial dysfunctionMyocardiopathiesMyocardiumNerveNerve CellsNerve Impulse TransmissionNerve TransmissionNerve UnitNervous System controlNeural CellNeuranatomiesNeuranatomyNeuroanatomiesNeuroanatomyNeurocyteNeuronal DysfunctionNeuronal TransmissionNeuronsNeurophysiology / ElectrophysiologyPathway interactionsPatternPharmaceutical PreparationsPharmacological TreatmentPharmacotherapyPhysiopathologyPigsPilot ProjectsPredispositionPreventionProcessResearch PersonnelResearchersResolutionSignal TransductionSignal Transduction SystemsSignalingStellate GangliasStellate GanglionStructureStructure of stellate ganglionSuidaeSusceptibilitySwineSympathetic GangliaSympathetic Nervous SystemTestingTherapeuticVentricle RemodelingVentricular ArrhythmiaVentricular Cardiac RemodelingVentricular Myocardial RemodelingVentricular RemodelingVentricular Tachycardiaanimal dataanti-inflammatory effectarrhythmic agentattenuateattenuatesaxon signalingaxon-glial signalingaxonal signalingbalancebalance functionbiological signal transductioncardiac devicecardiac dysfunctioncardiac implantcardiac infarctcardiac injurycardiac musclecardiodevicecardioprotectantcardioprotectioncardioprotectivecomputational toolboxcomputational toolscomputational toolsetcomputerized toolscoronary attackcoronary infarctcoronary infarctiondrug interventiondrug treatmentdrug/agentelectrophysiologicalextracellularglia signalingglial activationglial cell activationglial signalingheart attackheart dysfunctionheart infarctheart infarctionheart musclehuman modelimmune cell infiltrateimprovedin vivoinfarctinsightmodel of animalmodel of humanmultidisciplinarymyocardial remodelingmyocardium diseasemyocardium disordernerve signalingneuralneural controlneural dysfunctionneural inflammationneural networkneural regulationneural signalingneurochemicalneurochemistryneuroinflammationneuroinflammatoryneuromodulationneuromodulatoryneuronalneuronal signalingneurophysiologicalneurophysiologyneuroregulationneurotransmissionnew approachesnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynovelnovel approachesnovel strategiesnovel strategynovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachpathophysiologypathwaypharmaceutical interventionpharmacological interventionpharmacological therapypharmacology interventionpharmacology treatmentpharmacotherapeuticspilot studyporcinepreventpreventingprotective effectresolutionsrevascularizationside effectspatial and temporalspatial temporalspatiotemporalsudden cardiac deathsuidtooltranscriptomics
Description preview
PROJECT SUMMARY/ABSTRACT – Project 3
Ventricular tachycardia/fibrillation (VT/VF) occur after myocardial infarction (MI), and are a common cause of
sudden cardiac death. Sympathovagal imbalance, resulting from structural and functional remodeling of
cardiac sympathetic neurons, promotes the initiation of VT/VF after MI. This process remains poorly…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click