grant
Anti-nociceptive actions of CART II in chemotherapy-induced peripheral neuropathy
Organization VIRGINIA POLYTECHNIC INST AND ST UNIVLocation BLACKSBURG, UNITED STATESPosted 9 Jun 2023Deadline 31 May 2028
NIHUS FederalResearch GrantFY20255-HT5-Hydroxytryptamine5HT6,7-dinitroquinoxaline-2,3-dioneAbsence of pain sensationAbsence of sensibility to painAcuteAcute PainAcutely painfulAffectAffective DisordersAffinityAfter CareAfter-TreatmentAftercareAnalgesic AgentsAnalgesic DrugsAnalgesic PreparationAnalgesicsAnodynesAnti-Cancer AgentsAntineoplastic AgentsAntineoplastic DrugsAntineoplasticsAntinociceptive AgentsAntinociceptive DrugsAnxietyAnzataxAsotaxAssayBehaviorBehavior ControlBehavioralBehavioral ManipulationBioassayBiological AssayBrainBrain Nervous SystemBristaxolCART peptideCART proteinCARTPT geneCancer DrugCancer PatientCell BodyCell Communication and SignalingCell SignalingCellsChemicalsChemotherapy-induced peripheral neuropathyClinicalCocaine and Amphetamine Regulated TranscriptDNQXDataDifferences between sexesDiffers between sexesDoseEAA AntagonistsEncephalonEnteramineEvaluationExcitatory Amino Acid AntagonistsExhibitsFaceFeels no painFemaleGeneticGlutamate AntagonistsGlutamate Receptor AntagonistsGlutamatesHippophaineHyperalgesiaHyperalgesic SensationsHypersensitivityImpairmentIntracellular Communication and SignalingKO miceKnock-out MiceKnockout MiceL-GlutamateLPA ReceptorsLevarterenolLevonorepinephrineLysophosphatidic Acid ReceptorsMass Photometry/Spectrum AnalysisMass SpectrometryMass SpectroscopyMass SpectrumMass Spectrum AnalysesMass Spectrum AnalysisMeasuresMediatingMental DepressionMesencephalic Central GrayMiceMice MammalsMicrodialysisMidbrain Central GrayMolecularMood DisordersMurineMusNeoplastic Disease Chemotherapeutic AgentsNerve Impulse TransmissionNerve TransmissionNerve Transmitter SubstancesNeuronal TransmissionNeuropeptidesNeurotransmittersNo sensitivity to painNociceptionNoradrenalineNorepinephrineNucleus AccumbensNull MouseOpiate PeptidesOpiatesOpioidOpioid PeptideOutputPaclitaxelPaclitaxel (Taxol)PainPain ControlPain TherapyPain managementPainfulPatientsPeptidesPeriaqueductal GrayPharmacologic ActionsPharmacologyPilot ProjectsPraxelQOLQuality of lifeReceptor ProteinRiskRoleSafetySerotoninSex DifferencesSexual differencesSignal PathwaySignal TransductionSignal Transduction SystemsSignalingSiteSystemTactileTaxolTaxol ATaxol KonzentratTestingTherapeuticTumor-Specific Treatment AgentsWorkallodyniaanalgesiaannulus of the aqueductantagonismantagonistanti-cancer druganti-depressant agentanti-depressant drugsanti-depressantsanti-depressive agentsantinociceptionantinociceptiveaxon signalingaxon-glial signalingaxonal signalingbehavioral controlbiological signal transductionchronic paincocaine- and amphetamine-regulated transcript proteincomparing females and malescomparing women and mendepressiondrug candidateduloxetineexperimentexperimental researchexperimental studyexperimentsextracellularfacesfacialfemales compared to malesfemales compared with malesfemales versus malesfemales vs. malesglia signalingglial signalingglutamatergichyperalgiain vivoinhibitormalemidbrain central gray substancenerve signalingneural signalingneurochemicalneurochemistryneuronal signalingneuropathic painneurotransmissionnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapeuticsnew therapynew therapy approachesnew treatment approachnew treatment strategynext generation therapeuticsnociceptivenon-narcotic analgesicnon-opiate analgesicnon-opioidnon-opioid analgesicnon-opioid therapeuticsnonnarcotic analgesicsnonopiate analgesicnonopioidnonopioid analgesicsnovelnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapeuticsnovel therapynovel therapy approachpain interventionpain killerpain medicationpain reliefpain relieverpain treatmentpainful neuropathypainkillerperiaqueductal gray matterpilot studypositive allosteric modulatorpost treatmentpreventpreventingreceptorrelieve painresponseresponse to therapyresponse to treatmentsexsex based differencessex-dependent differencessex-related differencessex-specific differencessocial roletherapeutic responsetherapy responsetooltreatment responsetreatment responsivenessuptakewomen compared to menwomen compared with menwomen versus menwomen vs. men♀♂
Description preview
PROJECT SUMMARY
Chemotherapy-induced peripheral neuropathy (CIPN) manifests in nearly 70% of patients treated with anti-
neoplastic drugs and persists after treatment discontinuation, thereby impacting patient quality of life. The anti-
depressant duloxetine (selective inhibitor of serotonin and norepinephrine uptake) offers limited pain relief,…
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