grant
Anti-cancer vaccine targeting the host-parasite interface during fluke infection
Organization GEORGE WASHINGTON UNIVERSITYLocation WASHINGTON, UNITED STATESPosted 21 Sept 2012Deadline 31 Aug 2029
NIHUS FederalResearch GrantFY2025AddressAdjuvantAgeAntigen TargetingAntigensAntineoplastic VaccineAreaAsianAutoregulationAwardBile Duct CancerBile Duct CarcinomaBile TractBiliaryBiliary SystemBiliary TreeBiochemicalBiologicalBiological SymbiosisBlood SerumCRISPR approachCRISPR based approachCRISPR methodCRISPR methodologyCRISPR techniqueCRISPR technologyCRISPR toolsCRISPR-CAS-9CRISPR-based methodCRISPR-based techniqueCRISPR-based technologyCRISPR-based toolCRISPR/CAS approachCRISPR/Cas methodCRISPR/Cas technologyCRISPR/Cas9CRISPR/Cas9 technologyCancer Causing AgentsCancer InductionCancer ModelCancer TreatmentCancer VaccinesCancerModelCancersCarcinogensCas nuclease technologyCaspaseCaspase GeneCell CommunicationCell Growth in NumberCell InteractionCell MultiplicationCell ProliferationCell-Death ProteaseCell-to-Cell InteractionCellular ProliferationCervical cancer vaccineCessation of lifeCholangiocarcinomaCholangiocellular CarcinomaClinicClustered Regularly Interspaced Short Palindromic Repeats approachClustered Regularly Interspaced Short Palindromic Repeats methodClustered Regularly Interspaced Short Palindromic Repeats methodologyClustered Regularly Interspaced Short Palindromic Repeats techniqueClustered Regularly Interspaced Short Palindromic Repeats technologyCo-cultureCocultivationCocultureCoculture TechniquesCombination VaccinesCombined VaccinesCommunicationComplementComplement ProteinsCountryCricetinaeCysteine EndopeptidasesCysteine ProteaseCysteine ProteinasesDataDeathDevelopmentDigestionELISAEast AsiaEastern AsiaElementsEncapsulatedEnzyme-Linked Immunosorbent AssayEpitheliumEquationFar EastFasciola hepaticaFibrosisFlukesFundingGoalsGrowth AgentsGrowth FactorGrowth SubstancesHPVHamstersHamsters MammalsHelminthsHepatic CancerHepatocarcinogenesisHomeostasisHumanHuman Papilloma VirusHuman PapillomavirusICE-like proteaseIgEImmune responseImmunoglobulin EImpoverishedIn VitroIncidenceInfectionInfectious Human Wart VirusInterruptionLao People's Democratic RepublicLaosLinkLiver CarcinogenesisLiver FlukeLow-resource areaLow-resource communityLow-resource environmentLow-resource regionLow-resource settingMalignantMalignant - descriptorMalignant Neoplasm TherapyMalignant Neoplasm TreatmentMalignant NeoplasmsMalignant TumorMalignant neoplasm of liverMessenger RNAModelingModern ManMolecularMucous body substanceMucusNIAIDNational Institute of Allergy and Infectious DiseaseNeoplasm VaccinesNutrientNutritionNutritionalOncogensOpisthorchis viverriniOrganoidsParasitesParasitic WormsPathogenesisPathogenicityPathogenicity FactorsPathologyPathway interactionsPersonsPhenotypePhysiological HomeostasisPopulationPovertyPreparationProcessProepithelin Conversion to Epithelin and Wound Repair ControlPrognosisProliferatingPropertyProtein SubunitsProteinsProteins Growth FactorsPublic HealthRNA vaccineRNA-based vaccineRecombinant ProteinsReportingResource-constrained areaResource-constrained communityResource-constrained environmentResource-constrained regionResource-constrained settingResource-limited areaResource-limited communityResource-limited environmentResource-limited regionResource-limited settingResource-poor areaResource-poor communityResource-poor environmentResource-poor regionResource-poor settingRiskRisk FactorsRodent ModelRoleSafetySamplingSerumStandardizationSubunit VaccinesTSP-2TSP2TestingThailandTherapeuticThrombospondin IITrematodaTumor VaccinesVaccinationVaccine AntigenVaccinesVirulence FactorsWound RepairWound Repair Pathwayagesanti-canceranti-cancer therapyanti-tumor vaccinebile ductbile ductulebiliary cancerbiliary tractbiobankbiologicbiorepositorycancer therapycancer-directed therapycarcinogenesiscarcinogenesis in the livercarcinogenicitycholangiocytecholangiosarcomachronic skin woundchronic woundcohortcombatcomplementationcystein proteasecystein proteinasecysteine endopeptidasedevelopmentaleggenzyme linked immunoassayextracellularextracellular vesiclesfeedingfitnessfood-bornfood-bornefoodbornfoodbornefunctional genomicsgranulinhepatic carcinogenesishepatocellular carcinogenesishost responsehuman modelimmune system responseimmunization strategyimmunogenimmunogenicimmunoresponsein vivoinnovateinnovationinnovativeknockout geneliver cancerliver cancer pathogenesisliver malignancyliver tumorigenesismRNAmRNA vaccinemRNA-based vaccinemalignancymalignant liver tumormodel of humanmucousneoplasm/cancernovelnutritiousoncogenic agentparasitismpathogenpathwaypreparationsrepairrepairedresponsesecretory proteinsheep liver flukesocial rolethrombospondin 2translational opportunitiestranslational potentialvaccination strategyvaccine antibodiesvaccine candidatevaccine efficacyvaccine for cancervaccine induced antibodiesvaccine-induced antibodieswart viruswound healingwound recoverywound resolution
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Project Summary
Liver fluke infection with Opisthorchis viverrini remains problematic in East Asia and is endemic in Thailand and
Laos, where ~10 million people are infected. The public health implications of this situation are substantial since
there is no stronger link between a human malignancy and a eukaryotic pathogen than that between…
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